|Oral (hard capsules, tablets)|
|Elimination half-life||17–21 hours|
|Excretion||40% excrete as unchanged umifenovir in feces (38.9%) and urine (0.12%)|
|Chemical and physical data|
|Molar mass||477.41 g/mol g·mol−1|
|3D model (JSmol)|
|(what is this?)|
Umifenovir (trade name Russian: Арбидол, Chinese: 阿比朵尔) is an antiviral treatment for influenza infection used in Russia and China. The drug is manufactured by Pharmstandard (Russian: Фармстандарт). Although some Russian studies have shown it to be effective, it is not approved for use in Western countries. Chemically, umifenovir features an indole core, functionalized at all but one positions with different substituents. The drug inhibits viral entry into target cells and also stimulates the immune response.
Testing of umifenovir's efficacy has mainly occurred in China and Russia, and it is well known in these two countries. Some of the Russian tests showed the drug to be effective and a direct comparison with Tamiflu showed similar efficiency in vitro and in a clinical setting.
Mode of action
Umifenovir inhibits membrane fusion. Umifenovir prevents contact between the virus and target host cells. Fusion between the viral capsid and the cell membrane of the target cell is inhibited. This prevents viral entry to the target cell, and therefore protects it from infection.
As well as specific antiviral action against both influenza A and influenza B viruses, umifenovir exhibits modulatory effects on the immune system. The drug stimulates a humoral immune response, induces interferon-production, and stimulates the phagocytic function of macrophages.
A more recent study (published online as an accepted manuscript by the Journal of Virology) by Pécheur et al. indicates that umifenovir also has in vitro effectiveness at preventing entry of Ebolavirus Zaïre Kikwit, Tacaribe arenavirus and human herpes virus 8 in mammalian cell cultures, while confirming umifenovir's suppressive effect in vitro on Hepatitis B and poliovirus infection of mammalian cells when introduced either in advance of viral infection or during infection.
Side effects in children include sensitization to the drug. No known overdose cases have been reported and allergic reactions are limited to people with hypersensitivity. The LD50 is more than 4 g/kg.
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- Recommended INN: List 65., WHO Drug Information, Vol. 25, No. 1, 2011, page 91
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- Pécheur EI, Borisevich V, Halfmann P, Morrey JD, Smee DF, Prichard M, Mire CE, Kawaoka Y, Geisbert TW, Polyak SJ (January 2016). "The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses". Journal of Virology. 90 (6): 3086–92. doi:10.1128/JVI.02077-15. PMC 4810626. PMID 26739045.
- "АРБИДОЛ® (ARBIDOL)". Vidal. Archived from the original on 4 February 2009.
- "Мастерлек" Pharmaceuticals, Moscow, Russia. Patent number № 2033157, Registry number № 003610/01.
- ‹See Tfd›(in Russian) Arbidol
- English published clinical studies and translations for Arbidol 1973–2016