Uncle Anesthesia is the Screaming Trees' fifth album and first full-length album on Epic Records. It was released on January 29, 1991. It includes two of the four tracks from the band's previous Epic release, Something About Today EP (1990). The album, recorded throughout June 1990, was the last to feature drumming by original member Mark Pickerel, who left on amicable terms in 1991 to work in a variety of projects. He was replaced by Barrett Martin.