The 1880 South Carolina United States House of Representatives elections were held on November 2, 1880 to select five Representatives for two-year terms from the state of South Carolina. All five incumbents were re-elected and the composition of the state delegation remained solely Democratic.
"Annual Report of the Secretary of State to the General Assembly of South Carolina." Reports and Resolutions of the General Assembly of the State of South Carolina at the Regular Session of 1880. Columbia, SC: James Woodrow, 1881, pp. 553–555.