The UpToDate system is marketed as an evidence-based clinical resource. It includes a collection of medical and patient information, access to Lexi-comp drug monographs and drug-to-drug, drug-to-herb and herb-to-herb interactions information, and a number of medical calculators. UpToDate is written by over 5,700 physician authors, editors and peer reviewers. It is available both via the Internet and offline on personal computers or mobile devices. It requires a subscription for full access.
The company was launched in 1992 by Dr. Burton D. Rose along with Dr. Joseph Rush out of Rose's home. They started with nephrology and have since added over twenty other specialties, with more in development.
UpToDate's articles are anonymously peer reviewed and it mandates the disclosure of conflicts of interest by the authors of its articles. In 2014 an article was published in the Journal of Medical Ethics which scrutinised six articles on UpToDate and DynaMed focusing on conditions where the best means of management is contested, or which are treated mostly by branded drugs. The authors found that all six articles examined from UpToDate contained numerous potential conflicts of interest, with contributors having worked as consultants for or received research grants or speaking fees from manufacturers of drugs mentioned in the relevant UpToDate entry.
Full access to the service requires a subscription, which cost US$495 per year as of 2014. UpToDate was made available for free in New Zealand after the Christchurch earthquake, in Haiti in 2010 and in Nepal in 2015 after the earthquake. The Global Health Delivery Project at Harvard University administers access to UpToDate for those who offer medical care to poor or underserved populations outside the United States.
- Rose, Burton. "The UpToDate Story". YouTube. UpToDateEBM. Retrieved 12 July 2015.
- Amber, Kyle T; Dhiman, Gaurav; Goodman, Kenneth W (3 February 2014). "Conflict of interest in online point-of-care clinical support websites". Journal of Medical Ethics. BMJ Publishing Group. 40: 578–580. doi:10.1136/medethics-2013-101625. Retrieved 19 September 2015.
- "Dear Tribal Health Directors" (PDF). Retrieved 21 November 2014.
- "UpToDate Provides Free Access to Its Medical Content to All Users in Japan". Retrieved 15 November 2015.
- "UpToDate International Grant Subscription Program". Retrieved 15 November 2015.