Upadacitinib

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Upadacitinib
Upadacitinib.svg
Clinical data
Pronunciation/juˌpædəˈstɪnɪb/
ew-PAD-ə-SY-ti-nib
Trade namesRinvoq
Other namesABT-494
AHFS/Drugs.comMonograph
MedlinePlusa619051
License data
Pregnancy
category
  • AU: D
  • Not recommended[1]
Routes of
administration
By mouth
Drug classJanus kinase (JAK) inhibitor
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding52%
MetabolismLiver (CYP3A major, CYP2D6 minor)[10]
MetabolitesM4, an acyl glucuronide
Elimination half-life9–14[9] (6–15[10]) hours
ExcretionMainly unchanged in feces (38%) and urine (24%)[9]
Identifiers
  • (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC17H19F3N6O
Molar mass380.375 g·mol−1
3D model (JSmol)
  • CC[C@@H]1CN(C(=O)NCC(F)(F)F)C[C@@H]1c1cnc2cnc3[nH]ccc3n12
  • InChI=1S/C17H19F3N6O/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27)/t10-,11+/m1/s1 checkY
  • Key:WYQFJHHDOKWSHR-MNOVXSKESA-N checkY

Upadacitinib, sold under the brand name Rinvoq, is a Janus kinase (JAK) inhibitor medication for the treatment of moderately to severely active rheumatoid arthritis and psoriatic arthritis in adults where methotrexate (a drug used to treat active arthritis) did not work well or could not be tolerated.[11] It was approved for medical use in the United States and in the European Union in 2019,[11][12][8] and was developed by the biotech company AbbVie. On January 14, 2022 Rinvoq received FDA approval for treating treatment refractory atopic dermatitis.

Common side effects include upper respiratory tract infections (common cold, sinus infections), nausea, cough, and fever.[8][7]

Upadacitinib works by blocking the action of enzymes called Janus kinases.[8] These enzymes are involved in setting up processes that lead to inflammation, and blocking their effect brings inflammation in the joints under control.[8]

Medical uses[edit]

Upadacitinib is indicated for the treatment of moderate to severe active rheumatoid arthritis in adults who have responded inadequately to, or who are intolerant to one or more disease-modifying antirheumatic drugs (DMARDs).[8] Upadacitinib may be used as monotherapy or in combination with methotrexate.[8][7]

Upadacitinib was approved on January 14, 2022 by the FDA for treating adults and children 12 years and older with moderate to severe treatment refractory atopic dermatitis.

Contraindications[edit]

The FDA issued a black box warning for Rinvoq for the following reasons:

The drug can induce marked deleterious changes to lymphocytes, neutrophils, hemoglobin, liver enzymes and lipids.

Moreover, reports of severe life-threatening infections have been reported as well as cases of lymphoma.

The drug is contraindicated in people with active tuberculosis and other severe infections, severe liver impairment (Child–Pugh score C), and during pregnancy.[9][13]

The use of upadacitinib in combination with other Janus kinase inhibitors, biologic DMARDs, or with potent immunosuppressants such as azathioprine and ciclosporin is not recommended.[7]

Interactions[edit]

Substances that strongly inhibit the liver enzyme CYP3A4, such as ketoconazole, itraconazole or clarithromycin, increase upadacitinib concentrations in the body. In a study, ketoconazole increased its AUC by 75%. Conversely, substances that strongly induce CYP3A4 lower upadacitinib concentrations. For example, rifampicin reduced the AUC by 60% in a study.[9][13]

Upadacitinib seems to be a weak inducer of CYP3A4, as it lowers concentrations of other substrates of this enzyme (such as the midazolam AUC by 26%). It has no effect on substrates of CYP1A2, CYP2B6, CYP2C9, CYP2C19 or CYP2D6.[9][13]

Side effects[edit]

Common side effects are upper respiratory tract infections such as common cold and sinus infections (13.5% of patients in studies), nausea (3.5%), cough (2.2%), fever, and increased liver enzymes.

The FDA issued a black warning for the following observed side effects such as pneumonia, cellulitis, tuberculosis, as well as shingles and other herpes infections.

In addition deleterious changes have occurred in lymphocytes neutrophils, hemoglobin, liver enzymes, and lipids.

During marketing, reports of lymphoma (cancer) were noted.[9][13]

Pharmacology[edit]

Mechanism of action[edit]

The Janus kinases (JAKs) are a family of cytoplasmic tyrosine kinases whose function is to transduce cytokine-mediated signals via the JAK-STAT pathway. There are four JAK subtypes, each of which has overlapping receptor responsibilities. Inhibitors of this enzyme family (jakinibs) have shown efficacy in treating certain inflammatory and autoimmune diseases such as rheumatoid arthritis and Crohn's disease. However, the first generation of these drugs, tofacitinib and ruxolitinib, lacked subtype selectivity, affecting JAK1/JAK3 and JAK1/JAK2 respectively. This has led to dose-limiting side effects in this otherwise promising class of drugs.[14][15] Upadacitinib is a second generation Janus kinase inhibitor that is selective for the JAK1 subtype of this enzyme over the JAK2 (74-fold), JAK3 (58-fold) and tyrosine kinase 2 subtypes.[16]

Pharmacokinetics[edit]

After oral intake, upadacitinib reaches highest concentrations in the blood plasma after two to four hours. A fatty meal has no clinically relevant effect on its resorption. Steady-state conditions are reached after four days; accumulation is minimal. There is no significant first pass effect. When in the bloodstream, 52% of the substance are bound to plasma proteins. It is mainly metabolized by CYP3A4, and possibly to a minor extent by CYP2D6. The most important pathway consists of oxidation to a carboxylic acid and subsequent glucuronidation, yielding a metabolite called M4. However, 79% of the drug are circulating in form of upadacitinib itself, and only 13% as M4. Other metabolites are only present in small fractions. None are pharmacologically active.[9][13]

The drug is excreted mainly as the original substance, of which 38% are found in the feces and 24% in the urine. The mean terminal half-life is 9 to 14 hours.[9][13]

Clinical trials[edit]

Phase I studies[edit]

A phase I study revealed that upadacitinib followed a bi-exponential disposition with a terminal half-life of 6–16 hours.[10] There was no significant accumulation over the dose range of 3–36 mg per day. No interaction was found in rheumatoid arthritis patients taking methotrexate. The most common adverse event was headache but its incidence was similar to that when taking placebo (15.6% for upadacitinib vs. 16.7% for placebo). An investigation into absorption and metabolism found that dosing after a high-fat meal had no effect on upadacitinib total drug exposure over time (area under the curve or AUC).[17]

Phase II studies[edit]

Two phase IIb studies were initiated to study the efficacy and safety of upadacitinib in patients with rheumatoid arthritis and one phase II study was initiated in patients with Crohn's disease.

BALANCE I[edit]

In the first study, 276 rheumatoid arthritis patients were recruited who had previously experienced inadequate response to anti–tumor necrosis factor (TNF) therapy and were currently on a stable dose of methotrexate.[18] Patients were randomized to receive 3, 6, 12, or 18 mg twice daily or placebo. The primary endpoint was a 20% improvement in symptoms according to the American College of Rheumatology improvement criteria (ACR20). At the completion of the study it was found that response rates were significantly higher in those receiving upadacitinib versus in those receiving placebo alone (36–42% and 22– 26%, respectively). Adverse events included headache, nausea, and infection but no infections were serious.

BALANCE II[edit]

In the second phase IIb study, 300 rheumatoid arthritis patients were recruited who have had an inadequate response to methotrexate.[19] Patients were randomized to receive 3, 6, 12, or 18 mg twice daily or placebo. The primary endpoint was a 20% improvement in symptoms according to the American College of Rheumatology improvement criteria (ACR20). At the completion of the study it was found that response rates were significantly higher in those receiving upadacitinib versus in those receiving placebo alone. (62%, 68%, 80%, 64%, and 76% for the 3, 6, 12, 18, and 24 mg doses, respectively) than with placebo (46%). Improvement in symptoms was rapid, with significant changes in disease scores by week 2. Adverse events were mild with infection being the most serious. One case of community-acquired pneumonia occurred at 12 mg.

CELEST[edit]

[needs update] In this 16-week study, 220 patients were recruited with moderately to severely active Crohn's disease. Participants must have also experienced an inadequate response to or intolerance to Immunotherapy or TNF inhibitors.[20][21] Patients were randomized to therapy with upadacitinib at 3, 6, 12, 24 mg twice daily or 24 mg once daily for 16 weeks or placebo, followed by blinded extension therapy for 36 weeks. The co-primary endpoints were the proportion of patients who achieved clinical remission (soft stool frequency or daily abdominal pain score) at week 16 and endoscopic remission at week 12 or 16. Secondary endpoints included significant clinical response (≥30% reduction in symptoms) at week 16 and endoscopic response (≥25% decrease in symptoms) at week 12 or 16. At 16 weeks 22% of patients taking the 24 mg twice daily dose achieved endoscopic remission with upadacitinib compared to 0% of patients taking placebo. 27% of patients taking the 6 mg twice daily dose achieved clinical remission compared to 11% of patients taking placebo. Adverse events did not appear to be dose-related. A single case of non-melanoma skin cancer was reported in the 24 mg twice daily group.

Phase III studies[edit]

Abbvie has planned a total of six phase III trials that will evaluate over 4,000 patients with moderate to severe rheumatoid arthritis.[22] Two Phase III trials are planned studying participants with psoriatic arthritis and one in participants with ulcerative colitis.

SELECT-COMPARE[edit]

In SELECT-COMPARE 1629 patients with moderate to severe rheumatoid arthritis and inadequate response to methotrexate were randomized (2:2:1) to once-daily upadacitinib 15mg, placebo, or adalimumab 40mg, on stable background methotrexate. Primary endpoints were ACR20 and DAS28CRP<2.6 versus placebo at week 12; inhibition of radiographic progression was evaluated at week 26. The study was designed and powered to test for non-inferiority and superiority of upadacitinib versus adalimumab clinically and functionally. At week 12, both primary endpoints were met for upadacitinib versus placebo (p≤0.001). ACR20 was achieved by 71% versus 36%, and DAS28CRP<2.6 by 29% versus 6%. Upadacitinib was superior to adalimumab for ACR50, DAS28CRP≤3.2, ΔPain and ΔHAQDI. At week 26, more patients on upadacitinib vs placebo or adalimumab achieved low disease activity or remission (p≤0.001). Radiographic progression was less and observed in fewer patients receiving upadacitinib versus placebo (p≤0.001). Up to week 26, adverse events (AEs) including serious infections were comparable for upadacitinib and adalimumab. The proportions of patients with serious AEs and AEs leading to discontinuation were highest for adalimumab; the proportion with herpes zoster and CPK elevations was highest for upadacitinib. Three malignancies, five MACE, and four deaths were reported, none on upadacitinib. Six venous thromboembolic events were reported [placebo, one; upadacitinib, two; adalimumab, three]. Upadacitinib was superior to placebo and adalimumab for improving signs, symptoms and physical function in RA patients on background methotrexate, and significantly inhibited radiographic progression versus placebo, while the overall safety profile was generally similar to adalimumab, except for higher rates of herpes zoster and CPK elevations on upadacitinib.[23]

SELECT-CHOICE[edit]

SELECT-CHOICE was a phase III trial comparing upadacitinib and abatacept in 612 people whose rheumatoid arthritis did not respond to biologic DMARDs. It compared their ability to reduce Disease Activity Score-28 with CRP (DAS-28 CRP), a measure of rheumatoid arthritis disease severity that includes number of tender and swollen joints, C-reactive protein level (a marker of inflammation), and overall health reported on a standardized scale. The trial found that after 12 weeks of treatment, people treated with upadacitinib had lower DAS-28 CRP scores and a higher rate of remission. There was also a higher rate of serious and opportunistic infections, elevated liver enzymes, and thromboembolism in the upadacitinib group.[24][25]

History[edit]

Upadacitinib was approved for medical use in the United States in August 2019.[26][11]

The US Food and Drug Administration (FDA) approved upadacitinib based on evidence from five clinical trials (Trial 1/NCT02706873, Trial 2/NCT02706951, Trial 3/NCT02675426, Trial 4/NCT02629159, Trial 5/NCT02706847) of 3,141 participants with active rheumatoid arthritis (RA).[11] The trials were conducted in Australia, New Zealand, Israel, South Africa, Asia, North/Central/South America, and Europe.[11]

Five trials established the benefits and side effects of upadacitinib.[11] Trials enrolled participants with moderate to severe active RA in whom disease-modifying antirheumatic drugs (DMARDS) did not work well or could not be tolerated.[11] All participants had at least six tender and six swollen joints, and increased levels of high sensitivity C-reactive protein (hsCRP).[11] hsCRP is a substance produced by the body to protect itself from illness.[11] Trials lasted up to 5 years.[11]

Trial 1 enrolled participants who had never been treated with methotrexate.[11] Participants were randomly assigned to receive one of two doses of upadacitinib or methotrexate daily for 24 weeks.[11] Neither the subject nor the healthcare providers knew which medication was being given until after this 24-week treatment period.[11]

Trial 2 enrolled participants in whom methotrexate did not work well.[11] Participants were randomly assigned to receive one of two doses of upadacitinib daily by mouth or continue their usual dose of methotrexate for 14 weeks.[11] At week 14, participants who were assigned to methotrexate received upadacitinib by mouth daily.[11] Neither the subject nor the healthcare providers knew which medication was being given.[11]

Trial 3 enrolled participants in whom DMARDS did not work well.[11] Participants were randomly assigned to receive one of two doses of upadacitinib or placebo daily by mouth in addition to DMARDS for 12 weeks.[11] At week 12, participants who received placebo were reassigned to upadacitinib daily.[11] Neither the subject nor the healthcare providers knew which medication was being given.[11]

Trial 4 enrolled participants in whom methotrexate did not work well.[11] Participants were randomly assigned to receive upadacitinib or placebo daily by mouth in addition to methotrexate for 14 weeks.[11] Participants receiving placebo who did not have adequate improvement of signs and/or symptoms could be switched to upadacitinib after week 14.[11] At week 26, all participants receiving placebo were switched to upadacitinib once daily by mouth.[11] Neither the subject nor the healthcare providers knew which medication was being given.[11]

Trial 5 enrolled participants in whom DMARDS did not work well or could not be tolerated.[11] Participants were randomly assigned to receive one of two doses of upadacitinib or placebo treatment daily added to DMARDs for 12 weeks.[11] At week 12, participants who received placebo were reassigned to upadacitinib daily.[11]

The benefit of upadacitinib was measured by comparing the proportion of participants treated with upadacitinib who achieved an American College of Rheumatology 20 (ACR20) response at week 12 or week 14 to the proportion of participants treated with MTX or placebo who achieved an ACR20 response.[11] ACR20 is a 20% improvement in signs and symptoms of RA.[11]

Upadacitinib was approved for medical use in the European Union in December 2019.[8]

Research[edit]

Upadacitinib has also demonstrated success in treating moderate to severe atopic dermatitis which it has been FDA approved to treat and has been found to have superior efficacy compared with placebo and dupilumab.[27]

References[edit]

  1. ^ "Upadacitinib (Rinvoq) Use During Pregnancy". Drugs.com. 23 September 2019. Archived from the original on 18 March 2020. Retrieved 17 March 2020.
  2. ^ "AusPAR: Upadacitinib". Therapeutic Goods Administration (TGA). 25 August 2021. Archived from the original on 4 September 2021. Retrieved 4 September 2021.
  3. ^ RINVOQ (Abbvie Pty Ltd)
  4. ^ "Rinvoq Product information". Health Canada. 25 April 2012. Archived from the original on 30 May 2022. Retrieved 29 May 2022.
  5. ^ "Summary Basis of Decision (SBD) for Rinvoq". Health Canada. 23 October 2014. Archived from the original on 31 May 2022. Retrieved 29 May 2022.
  6. ^ "Rinvoq 15 mg prolonged-release tablets - Summary of Product Characteristics (SmPC)". (emc). 1 March 2020. Archived from the original on 27 August 2021. Retrieved 22 August 2020.
  7. ^ a b c d "Rinvoq- upadacitinib tablet, extended release". DailyMed. 1 March 2020. Archived from the original on 27 August 2021. Retrieved 29 April 2020.
  8. ^ a b c d e f g h "Rinvoq EPAR". European Medicines Agency (EMA). 16 October 2019. Archived from the original on 20 October 2020. Retrieved 29 April 2020.
  9. ^ a b c d e f g h "Rinvoq: EPAR – Public assessment report" (PDF). European Medicines Agency. 5 March 2020. Archived (PDF) from the original on 21 July 2020. Retrieved 21 July 2020.
  10. ^ a b c Mohamed MF, Camp HS, Jiang P, Padley RJ, Asatryan A, Othman AA (December 2016). "Pharmacokinetics, Safety and Tolerability of ABT-494, a Novel Selective JAK 1 Inhibitor, in Healthy Volunteers and Participants with Rheumatoid Arthritis". Clinical Pharmacokinetics. 55 (12): 1547–1558. doi:10.1007/s40262-016-0419-y. PMID 27272171. S2CID 39036534.
  11. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae "Drug Trials Snapshots: Rinvoq". U.S. Food and Drug Administration (FDA). 16 August 2019. Archived from the original on 5 August 2020. Retrieved 18 March 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  12. ^ "AbbVie Receives FDA Approval of RINVOQ (upadacitinib), an Oral JAK Inhibitor for the Treatment of Moderate to Severe Rheumatoid Arthritis" (Press release). AbbVie. Archived from the original on 16 August 2019. Retrieved 16 August 2019.
  13. ^ a b c d e f Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. 2020. Rinvoq 15 mg Retardtabletten.
  14. ^ Fleischmann R (May 2012). "Novel small-molecular therapeutics for rheumatoid arthritis". Current Opinion in Rheumatology. 24 (3): 335–41. doi:10.1097/BOR.0b013e32835190ef. PMID 22357358. S2CID 826984.
  15. ^ Riese RJ, Krishnaswami S, Kremer J (August 2010). "Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes". Best Practice & Research. Clinical Rheumatology. 24 (4): 513–26. doi:10.1016/j.berh.2010.02.003. PMID 20732649.
  16. ^ "Characterization of ABT-494, a Second Generation Jak1 Selective Inhibitor". ACR Meeting Abstracts. Archived from the original on 8 December 2017. Retrieved 21 May 2017.
  17. ^ Mohamed MF, Jungerwirth S, Asatryan A, Jiang P, Othman AA (October 2017). "Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high-fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib". British Journal of Clinical Pharmacology. 83 (10): 2242–2248. doi:10.1111/bcp.13329. PMC 5595971. PMID 28503781.
  18. ^ Kremer JM, Emery P, Camp HS, Friedman A, Wang L, Othman AA, et al. (December 2016). "A Phase IIb Study of ABT-494, a Selective JAK-1 Inhibitor, in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti-Tumor Necrosis Factor Therapy". Arthritis & Rheumatology. 68 (12): 2867–2877. doi:10.1002/art.39801. PMC 5132116. PMID 27389975.
  19. ^ Genovese MC, Smolen JS, Weinblatt ME, Burmester GR, Meerwein S, Camp HS, et al. (December 2016). "Efficacy and Safety of ABT-494, a Selective JAK-1 Inhibitor, in a Phase IIb Study in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate". Arthritis & Rheumatology. 68 (12): 2857–2866. doi:10.1002/art.39808. PMC 5132065. PMID 27390150.
  20. ^ "A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of ABT-494 for the Induction of Symptomatic and Endoscopic Remission in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Immunomodulators or Anti-TNF Therapy - Full Text View - ClinicalTrials.gov". Archived from the original on 8 September 2017. Retrieved 22 May 2017.
  21. ^ "AbbVie Announces Positive Phase 2 Study Results for Upadacitinib (ABT-494), an Investigational JAK1-Selective Inhibitor, in Crohn's Disease". Archived from the original on 17 February 2018. Retrieved 22 May 2017.
  22. ^ "Phase 3 upadacitinib trials". Archived from the original on 27 August 2021. Retrieved 22 May 2017.
  23. ^ Fleischmann R, Pangan AL, Song IH, Mysler E, Bessette L, Peterfy C, et al. (November 2019). "Upadacitinib Versus Placebo or Adalimumab in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate: Results of a Phase III, Double-Blind, Randomized Controlled Trial". Arthritis Rheumatol. 71 (11): 1788–1800. doi:10.1002/art.41032. PMID 31287230. S2CID 195843803.
  24. ^ Rubbert-Roth A, Enejosa J, Pangan AL, Haraoui B, Rischmueller M, Khan N, et al. (October 2020). "Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis". The New England Journal of Medicine. 383 (16): 1511–1521. doi:10.1056/NEJMoa2008250. PMID 33053283. S2CID 222420294.
  25. ^ "A Phase 3 Study to Compare Upadacitinib to Abatacept in Subjects With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease- Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response or Intolerance to Biologic DMARDs". Clinicaltrials.gov. 29 July 2021. Archived from the original on 17 April 2021. Retrieved 24 October 2020.
  26. ^ "Drug Approval Package: Rinvoq". U.S. Food and Drug Administration (FDA). 12 September 2019. Archived from the original on 30 March 2021. Retrieved 29 April 2020.
  27. ^ Blauvelt A, Teixeira HD, Simpson EL, Costanzo A, De Bruin-Weller M, Barbarot S, et al. (September 2021). "Efficacy and Safety of Upadacitinib vs Dupilumab in Adults With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial". JAMA Dermatol. 157 (9): 1047–55. doi:10.1001/jamadermatol.2021.3023. PMC 8340015. PMID 34347860.

External links[edit]

  • "Upadacitinib". Drug Information Portal. U.S. National Library of Medicine.
  • Clinical trial number NCT02706873 for "A Study to Compare Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have Not Previously Taken Methotrexate (SELECT-EARLY)" at ClinicalTrials.gov
  • Clinical trial number NCT02706951 for "A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY)" at ClinicalTrials.gov
  • Clinical trial number NCT02675426 for "A Study Comparing Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on a Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response to csDMARDs Alone (SELECT-NEXT)" at ClinicalTrials.gov
  • Clinical trial number NCT02629159 for "A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate (SELECT-COMPARE)" at ClinicalTrials.gov
  • Clinical trial number NCT02706847 for "A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) With an Inadequate Response or Intolerance to Biologic DMARDs (SELECT-BEYOND)" at ClinicalTrials.gov