Uramustine

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Uramustine
Uramustine.svg
Systematic (IUPAC) name
5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione
Pharmacokinetic data
Protein binding 5%
Excretion Renal
Identifiers
CAS Registry Number 66-75-1 YesY
ATC code None
PubChem CID: 6194
IUPHAR/BPS 7621
DrugBank DB00791 N
ChemSpider 5959 N
UNII W7KQ46GJ8U N
KEGG D06265 YesY
ChEMBL CHEMBL1488 N
Chemical data
Formula C8H11Cl2N3O2
Molecular mass 252.097 g/mol
 N (what is this?)  (verify)

Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects.

Chemically it is a derivative of nitrogen mustard and uracil.