Ureaplasma urealyticum

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ureaplasma urealyticum
Scientific classification
Kingdom: Bacteria
Division: Firmicutes
Class: Mollicutes
Order: Mycoplasmatales
Family: Mycoplasmataceae
Genus: Ureaplasma
Species: U. urealyticum
Binomial name
Ureaplasma urealyticum
Shepard et al., 1974

Ureaplasma urealyticum is a bacterium belonging to the family Mycoplasmataceae. Its type strain is T960.

Clinical significance[edit]

Ureaplasma urealyticum is a species in the genus Ureaplasm noted for its lack of a cell wall. It is found in about 70% of sexually active humans.[1] It is present as a pathogen in cases of pelvic inflammatory disease and is transmitted through sexual activity or from mother to infant during birth.[2]

It had also been associated with a number of diseases in humans, including nonspecific urethritis, infertility,[3] chorioamnionitis, stillbirth, premature birth, and, in the perinatal period, pneumonia, bronchopulmonary dysplasia[4] and meningitis.[5] U. urealyticum has been noted as one of the infectious causes of sterile pyuria.[6]

If infection with this bacterium goes undetected, untreated or recurs, it reduces the fertility of both men and women, causes internal scarring, and has been implicated as the cause in preterm births, stillbirths, sepsis in newborns.[2]


The six recognised Ureaplasma species have a GC content of 27–30%, and a genome size ranging from 0.76 to 1.17 Mbase pairs, and cholesterol is required for growth.[7] A defining characteristic of the genus is that they perform urea hydrolysis. Some strains originally classified as U. urealyticum should be treated as a new species, U. parvum.[citation needed]


Doxycycline is the drug of choice, but azithromycin is also used as a five-day course rather than a single dose that would be used to treat Chlamydia infection;[8] streptomycin is an alternative, but is less popular because it must be injected. Penicillins are ineffective — U. urealyticum does not have a cell wall,[9] which is the drug's main target.[10][11]

See also[edit]


  1. ^ "Ureaplasma urealyticum". HealthExpress. 
  2. ^ a b Ljubin-Sternak, Suncanica; Mestrovic, Tomislav (2014). "Review: Clamydia trachonmatis and Genital Mycoplasmias: Pathogens with an Impact on Human Reproductive Health". Journal of Pathogens 2014 (183167). doi:10.1155/204/183167. PMC 4295611. PMID 25614838. 
  3. ^ C. Huang; H.L. Zhu; K.R. Xu; S.Y. Wang; L.Q. Fan; W.B. Zhu (September 2015). "Mycoplasma and ureaplasma infection and male infertility: a systematic review and meta-analysis". Andrology 3 (5): 809–816. doi:10.1111/andr.12078. PMID 26311339. 
  4. ^ Kafetzis DA, Skevaki CL, Skouteri V, et al. (October 2004). "Maternal genital colonization with Ureaplasma urealyticum promotes preterm delivery: association of the respiratory colonization of premature infants with chronic lung disease and increased mortality". Clin. Infect. Dis. 39 (8): 1113–22. doi:10.1086/424505. PMID 15486833. 
  5. ^ Queena, John T. .; Spong, Catherine Y; Lockwood, Charles J., editors (2012). Queenan's management of high-risk pregnancy : an evidence-based approach (6th ed.). Chichester, West Sussex: Wiley-Blackwell. ISBN 9780470655764. 
  6. ^ Dieter RS (2000). "Sterile pyuria: a differential diagnosis". Compr Ther 26 (3): 150–2. doi:10.1007/s12019-000-0001-1. PMID 10984817. 
  7. ^ "Ureaplasma urealyticum- Classification". Meducation.net. 
  8. ^ "Ureaplasma Urealyticum and Parvum Test Online". thesticlinic.com. 
  9. ^ "Modified Real-Time PCR for Detecting, Differentiating, and Quantifying Ureaplasma urealyticum and Ureaplasma parvum". PubMed Central (PMC). 
  10. ^ "Drugs - Pencillin". elmhurst.edu. 
  11. ^ Pignanelli S, Pulcrano G, Iula VD, Zaccherini P, Testa A, Catania MR (2013). "In vitro antimicrobial profile of Ureaplasma urealyticum from genital tract of childbearing-aged women in Northern and Southern Italy". APMIS. 122 (6): 552–5. doi:10.1111/apm.12184. PMID 24106832. 

External links[edit]