Ureaplasma urealyticum infection

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Ureaplasma urealyticum infection
Typesinfectious disease

Ureaplasma urealyticum is a type of bacteria that can cause infection of the urinary tract and vagina. It can be passed from mother to infant during birth, or be sexually transmitted.[1] Ureaplasma urealyticum can be found in a majority of sexually active people,[citation needed] most of whom are asymptomatic.[2] It can also be found in cultures in cases of pelvic inflammatory disease. It is not a commensal of the healthy uterine or amniotic microbiome. Infection with U. urealyticum can contribute to neonatal infection and negative birth outcomes.



It had also been associated with a number of diseases in humans, including nonspecific urethritis, and infertility.[3][4]

Women and infants[edit]

Infection in the newborn is accompanied by a strong immune response and is correlated with the need for prolonged mechanical ventilation.[5] Infection with U. urealyticum in pregnancy and birth can be complicated by chorioamnionitis, stillbirth, premature birth,[1] and, in the perinatal period, pneumonia, bronchopulmonary dysplasia[6] and meningitis.[7] U. urealyticum has been found to be present in amniotic fluid in women who have had a premature birth with intact fetal membranes.[8][9]

U. urealyticum has been noted as one of the infectious causes of sterile pyuria.[10] It increases the morbidity as a cause of neonatal infections.[5] It is associated with premature birth, preterm rupture of membranes, preterm labor, cesarean section, placental inflammation, congenital pneumonia, bacteremia, meningitis, fetal lung injury and death of infant.[4] Ureaplasma urealyticum is associated with miscarriage.[11] In addition, this pathogen may latently infect the chorionic villi tissues of pregnant women, thereby impacting pregnancy outcome.[12]



Doxycycline is the drug of choice, but azithromycin is also used as a five-day course rather than a single dose that would be used to treat Chlamydia infection;[13] streptomycin is an alternative, but is less popular because it must be injected. Penicillins are ineffective — U. urealyticum does not have a cell wall,[14] which is the drug's main target.[15][16]


  1. ^ a b Ljubin-Sternak, Suncanica; Mestrovic, Tomislav (2014). "Review: Chlamydia trachonmatis and Genital Mycoplasmias: Pathogens with an Impact on Human Reproductive Health". Journal of Pathogens. 2014 (183167): 183167. doi:10.1155/2014/183167. PMC 4295611. PMID 25614838.
  2. ^ "Mycoplasma and Ureaplasma: Are they Sexually Transmitted Infections?". Treated.com. Retrieved 2019-04-23.
  3. ^ C. Huang; H.L. Zhu; K.R. Xu; S.Y. Wang; L.Q. Fan; W.B. Zhu (September 2015). "Mycoplasma and ureaplasma infection and male infertility: a systematic review and meta-analysis". Andrology. 3 (5): 809–816. doi:10.1111/andr.12078. PMID 26311339. S2CID 39834287.
  4. ^ a b Medscape (2017-11-17). "Ureaplasma Infection: Background, Pathophysiology, Epidemiology". Cite journal requires |journal= (help)
  5. ^ a b Pryhuber, Gloria S. (2015). "Postnatal Infections and Immunology Affecting Chronic Lung Disease of Prematurity". Clinics in Perinatology. 42 (4): 697–718. doi:10.1016/j.clp.2015.08.002. ISSN 0095-5108. PMC 4660246. PMID 26593074; Access provided by the University of PittsburghCS1 maint: postscript (link)
  6. ^ Kafetzis DA, Skevaki CL, Skouteri V, et al. (October 2004). "Maternal genital colonization with Ureaplasma urealyticum promotes preterm delivery: association of the respiratory colonization of premature infants with chronic lung disease and increased mortality". Clin. Infect. Dis. 39 (8): 1113–22. doi:10.1086/424505. PMID 15486833.
  7. ^ Queena, John T. .; Spong, Catherine Y; Lockwood, Charles J., editors (2012). Queenan's management of high-risk pregnancy : an evidence-based approach (6th ed.). Chichester, West Sussex: Wiley-Blackwell. ISBN 9780470655764.
  8. ^ Payne, Matthew S.; Bayatibojakhi, Sara (2014). "Exploring Preterm Birth as a Polymicrobial Disease: An Overview of the Uterine Microbiome". Frontiers in Immunology. 5: 595. doi:10.3389/fimmu.2014.00595. ISSN 1664-3224. PMC 4245917. PMID 25505898.
  9. ^ "Genital Wart Guide". Monday, 15 February 2021
  10. ^ Dieter RS (2000). "Sterile pyuria: a differential diagnosis". Compr Ther. 26 (3): 150–2. doi:10.1007/s12019-000-0001-1. PMID 10984817. S2CID 11629600.
  11. ^ Cunningham, F, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, Casey BM, Sheffield JS (2013). "Abortion". Williams Obstetrics. McGraw-Hill. p. 5.
  12. ^ Contini C, Rotondo JC, Magagnoli F, Maritati M, Seraceni S, Graziano A, Poggi A, Capucci R, Vesce F, Tognon M, Martini F (2018). "Investigation on silent bacterial infections in specimens from pregnant women affected by spontaneous miscarriage". J Cell Physiol. 234 (1): 100–9107. doi:10.1002/jcp.26952. PMID 30078192.
  13. ^ "Ureaplasma Urealyticum and Parvum Test Online". thesticlinic.com.
  14. ^ Vancutsem E, Soetens O, Breugelmans M, Foulon W, Naessens A (2011). "Modified Real-Time PCR for Detecting, Differentiating, and Quantifying Ureaplasma urealyticum and Ureaplasma parvum". J Mol Diagn. 13 (2): 206–12. doi:10.1016/j.jmoldx.2010.10.007. PMC 3128564. PMID 21354056.CS1 maint: multiple names: authors list (link)
  15. ^ "Drugs — Pencillin". elmhurst.edu.
  16. ^ Pignanelli S, Pulcrano G, Iula VD, Zaccherini P, Testa A, Catania MR (2013). "In vitro antimicrobial profile of Ureaplasma urealyticum from genital tract of childbearing-aged women in Northern and Southern Italy". APMIS. 122 (6): 552–5. doi:10.1111/apm.12184. PMID 24106832. S2CID 5120886.

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