Urethral syndrome

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Urethral syndrome
Classification and external resources
Specialty urology
ICD-10 N34.3
ICD-9-CM 597.81
eMedicine med/3081
Patient UK Urethral syndrome

Urethral syndrome is a set of symptoms that may suggest a lower urinary tract infection. However, urethral syndrome is different since there is no significant presence of bacteriuria with a conventional pathogen.[1] Typically, the syndrome can be linked to non-infective causes such as trauma, allergies, anatomical features such as diverticula, and post-surgical scarring and adhesions.


Signs indicative of urethral syndrome include a history of chronic recurrent urinary tract infections (UTI) in the absence of both conventional bacterial growth,[2] and pyuria (more than 5 white blood cells per High Power Field). Episodes are often related to sexual intercourse.

Some physicians believe that urethral syndrome may be due to a low grade infection of the Skene's glands on the sides and bottom of the urethra.[citation needed] The Skene's glands are embryologically related to the prostate gland in the male, thus urethral syndrome may share a comparable etiology with chronic prostatitis.[citation needed]


Treatment of acute urethral syndrome involves antibiotics.[vague][citation needed] For chronic urethral syndrome, a long term, low-dose antibiotic treatment is given on a continuous basis or after intercourse each time if intercourse appears to trigger symptoms.[citation needed]

As a hormonal imbalance may also be considered a source for urethral syndrome, hormone replacement therapy, and oral contraceptive pill (birth-control pills) are also used to treat the symptoms of this condition.[3]

See also[edit]


  1. ^ Hamilton-Miller JM (May 1994). "The urethral syndrome and its management". J. Antimicrob. Chemother. 33. Suppl A: 63–73. PMID 7928838. 
  2. ^ Brumfitt W, Hamilton-Miller JM, Gillespie WA (July 1991). "The mysterious "urethral syndrome"". BMJ 303 (6793): 1–2. doi:10.1136/bmj.303.6793.1. PMC 1670265. PMID 1859947. 
  3. ^ Terris, Martha K. "Urethral Syndrome". eMedicine. Retrieved 2008-09-25. 

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