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guanylate cyclase activator 2B (uroguanylin)
Symbol GUCA2B
Entrez 2981
HUGO 4683
OMIM 601271
RefSeq NM_007102
UniProt Q16661
Other data
Locus Chr. 1 p34-p33
Stereo, skeletal formula of uroguanylin
3D model (JSmol)
MeSH uroguanylin
Molar mass 1,600.81 g·mol−1
Related compounds
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in intestinal and renal epithelia. Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.

In humans, the uroguanylin peptide is encoded by the GUCA2B gene.[1][2] Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.[3]

See also[edit]


  1. ^ Miyazato M, Nakazato M, Yamaguchi H, Date Y, Kojima M, Kangawa K, Matsuo H, Matsukura S (February 1996). "Cloning and characterization of a cDNA encoding a precursor for human uroguanylin". Biochemical and Biophysical Research Communications. 219 (2): 644–8. doi:10.1006/bbrc.1996.0287. PMID 8605041. 
  2. ^ Miyazato M, Nakazato M, Matsukura S, Kangawa K, Matsuo H (August 1997). "Genomic structure and chromosomal localization of human uroguanylin". Genomics. 43 (3): 359–65. doi:10.1006/geno.1997.4808. PMID 9268639. 
  3. ^ Rahbi H, Narayan H, Jones DJ, Ng LL (December 2012). "The uroguanylin system and human disease". Clinical Science. 123 (12): 659–68. doi:10.1042/CS20120021. PMID 22877138. 

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