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The reference interaction-site model (RISM) is an approximation of the Ornstein–Zernike equation. Its most common use is computational modelling of solvation thermodynamics. Its computational performance is intermediate between coarse grain models such as the Poisson-Boltzmann equation and fine grain models like molecular dynamics. The RISM was developed by Hans C. Andersen and David Chandler in 1970.[1]



A number of chemistry software packages have implemented the RISM, including AMBER. Typical methods for computationally solving the RISM equation include finite difference solvers, ... Some methods of solving the RISM equation are trivially paralellizable.


  1. ^ Andersen, Hans C. (1970-07-15). "Mode Expansion in Equilibrium Statistical Mechanics. I. General Theory and Application to the Classical Electron Gas". The Journal of Chemical Physics. 53 (2): 547–554. doi:10.1063/1.1674024. ISSN 0021-9606. Retrieved 2013-01-31.  Unknown parameter |coauthors= ignored (|author= suggested) (help)