User:Benjah-bmm27/degree/3/GCLJ2

From Wikipedia, the free encyclopedia
< User:Benjah-bmm27‎ | degree‎ | 3
Jump to: navigation, search

Synthetic uses of transition metals, GCLJ[edit]

Textbooks[edit]

  • Clayden, Chapter 48 (Organometallic chemistry), pp. 1311–1343

Introduction[edit]

Pd-catalyzed coupling reactions[edit]

Stille[edit]

Suzuki[edit]

Negishi[edit]

Kumada[edit]

Sonogashira[edit]

Use of Sonogashira coupling in enediyne synthesis[edit]

Hartwig-Buchwald coupling[edit]

  • "Amination", R-X → R-NH-R′
  • RX + R′NH2 → RNHR′ + HX
  • Catalysed by 0PdL2
  • [R′H2N+PdL2R][X] deprotonated

sp³ hybridised carbon in the oxidative addition process[edit]

Heck reaction[edit]

Mechanism[edit]

Other interactions of alkenes with Pd(II)[edit]

Cyclopropanation using electrophilic carbene complexes[edit]

Cilastatin synthesis[edit]

  • Example of a Cu-catalysed asymmetric cyclopropanation: synthesis of cilastatin

Ring-closing metathesis[edit]