User:Cboursnell/Sandbox/7TM GPCR Srbc

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7TM_GPCR_Srbc
File:PDB NULL EBI.jpg
Identifiers
Symbol 7TM_GPCR_Srbc
Pfam PF10316
Pfam clan CL0192
InterPro IPR019420

G-protein-coupled receptors, GPCRs, constitute a vast protein family that encompasses a wide range of functions (including various autocrine, paracrine and endocrine processes). They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence.[1] The currently known clan members include the rhodopsin-like GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating pheromone receptors, and the metabotropic glutamate receptor family. There is a specialised database for GPCRs (http://www.gpcr.org/7tm/).

The nematode Caenorhabditis elegans has only 14 types of chemosensory neuron, yet is able to sense and respond to several hundred different chemicals because each neuron detects several stimuli.[2] Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.[3] Chemoreception in C. elegans is mediated by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs). More than 1300 potential chemoreceptor genes have been identified in C. elegans, which are generally prefixed sr for serpentine receptor. The receptor superfamilies include Sra (Sra, Srb, Srab, Sre), Str (Srh, Str, Sri, Srd, Srj, Srm, Srn) and Srg (Srx, Srt, Srg, Sru, Srv, Srxa), as well as the families Srw, Srz, Srbc, Srsx and Srr.[4][3][5] Many of these proteins have homologues in Caenorhabditis briggsae.

This entry represents serpentine receptor class b (Srb) from the Sra superfamily.[5] Srb receptors contain 6-8 hydrophobic, putative transmembrane, regions and can be distinguished from other 7TM GPCR receptors by their own characteristic TM signatures.

Srbc is a solo family amongst the superfamilies of chemoreceptors.


References[edit]

  1. ^ Attwood TK, Findlay JB (1994). "Fingerprinting G-protein-coupled receptors". Protein Eng. 7 (2): 195–203. PMID 8170923.  Unknown parameter |month= ignored (help); C1 control character in |pages= at position 5 (help)
  2. ^ Troemel ER (1999). "Chemosensory signaling in C. elegans". Bioessays. 21 (12): 1011–20. doi:10.1002/(SICI)1521-1878(199912)22:1<1011::AID-BIES5>3.0.CO;2-V. PMID 10580986.  Unknown parameter |month= ignored (help); C1 control character in |pages= at position 6 (help)
  3. ^ a b Robertson HM, Thomas JH (2006). "The putative chemoreceptor families of C. elegans". WormBook: 1–12. doi:10.1895/wormbook.1.66.1. PMID 18050473.  C1 control character in |pages= at position 3 (help)
  4. ^ Troemel ER, Chou JH, Dwyer ND, Colbert HA, Bargmann CI (1995). "Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans". Cell. 83 (2): 207–18. PMID 7585938.  Unknown parameter |month= ignored (help); C1 control character in |pages= at position 5 (help)
  5. ^ a b Chen N, Pai S, Zhao Z, Mah A, Newbury R, Johnsen RC, Altun Z, Moerman DG, Baillie DL, Stein LD (2005). "Identification of a nematode chemosensory gene family". Proc. Natl. Acad. Sci. U.S.A. 102 (1): 146–51. doi:10.1073/pnas.0408307102. PMC 539308Freely accessible. PMID 15618405.  Unknown parameter |month= ignored (help); C1 control character in |pages= at position 5 (help)

This article incorporates text from the public domain Pfam and InterPro IPR019420

Category:Protein families