User:EBMLibrarian/sandbox/tetracycline
Use of tetracycline antibiotics can:[1]
- Discolor permanent teeth (yellow-gray-brown), from prenatal period through childhood and adulthood[2]. Children receiving long- or short-term therapy with a tetracycline or glycylcycline may develop permanent brown discoloration of the teeth.
- Be inactivated by calcium ions, so are not to be taken with milk, yogurt, and other dairy products
- Be inactivated by aluminium, iron, and zinc ions, not to be taken at the same time as indigestion remedies (some common antacids and over-the-counter heartburn medicines)
- Cause skin photosensitivity[3], so exposure to the sun or intense light is not recommended
- Cause drug-induced lupus, and hepatitis
- Cause microvesicular fatty liver[4]
- Cause tinnitus[5]
- Interfere with methotrexate by displacing it from the various protein-binding sites
- Cause breathing complications, as well as anaphylactic shock, in some individuals
- Affect bone growth of the fetus, so should be avoided during pregnancy
- Fanconi syndrome may result from ingesting expired tetracyclines.
Caution should be exercised in long-term use when breastfeeding. Short-term use is safe; bioavailability in milk is low to nil.[6] According to the U.S. Food and Drug Administration (FDA), cases of Stevens–Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme associated with doxycycline use have been reported, but a causative role has not been established.
- ^ "Tetracycline: MedlinePlus Drug Information". medlineplus.gov. Archived from the original on 2017-05-10. Retrieved 2017-05-19.
- ^ Sánchez, Andrés R.; Rogers, Roy S.; Sheridan, Phillip J. (October 2004). "Tetracycline and other tetracycline-derivative staining of the teeth and oral cavity". International Journal of Dermatology. 43 (10): 709–715. doi:10.1111/j.1365-4632.2004.02108.x. ISSN 0011-9059. PMID 15485524.
- ^ Shutter, Mollie C.; Akhondi, Hossein (2024), "Tetracycline", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 31751095, retrieved 2024-03-19
- ^ "Demeclocycline", LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases, 2012, PMID 31644155, retrieved 2024-03-20
- ^ Schlossberg DL, Samuel R (2017). Antibiotics Manual : A Guide to Commonly Used Antimicrobials. John Wiley & Sons, Inc. p. 367 – via ProQuest Ebook Central.
- ^ Riordan J, Wambach K, eds. (November 2010). Breastfeeding and Human Lactation. Jones & Bartlett Learning. p. 179.
https://medlineplus.gov/druginfo/meds/a682098.html
AHFS Patient Medication Information [Internet]. Bethesda (MD): American Society of Health-System Pharmacists, Inc.; c2019. Tetracycline; [updated 2020 Jun 24; reviewed 2017 Aug 15; cited 2024 Mar 12]; [about 5 p.]. Available from: https://medlineplus.gov/druginfo/meds/a682098.html