User:ProteinBoxBot/PBB Log Wiki 11-8-2007 A-11

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Log file for Protein Box Bot[edit]

Log page index: User:ProteinBoxBot/PBB_Log_Index

Protein Status Quick Log - Date: 00:45, 9 November 2007 (UTC)[edit]

Proteins without matches (20)[edit]

HIPK2 ATP2B4 GRM1 MPL LAMA3
NOX1 SIRPA ANK1 ADH1C MLLT4
MAP2K3 NTRK3 F11R ADORA1 APOC1
PKLR ALDOA PLEC1 NRF1 TPP1

Proteins with a High Potential Match (5)[edit]

LOX HNRPC CUTL1 GUSB TUBB

Created (9)[edit]

HIPK2 NOX1 ADH1C MLLT4 MAP2K3
NTRK3 ADORA1 APOC1 NRF1

Manual Inspection (Page not found) (16)[edit]

ATP2B4 LOX GRM1 MPL HNRPC
LAMA3 SIRPA CUTL1 ANK1 GUSB
F11R PKLR ALDOA TUBB PLEC1
TPP1


Protein Status Grid - Date: 00:45, 9 November 2007 (UTC)[edit]

HUGO Symbol Action Summary Target page(s) WP Symbol Search
HIPK2 Created Other Pages: Homeodomain interacting protein kinase 2 (No Data); HIPK2 (No Data); PRO0593 (No Data); Pro0593 (No Data); [1]
ATP2B4 Manual Inspection (Page not found) Other Pages: ATPase (Unknown Data); ATP2B4 (No Data); ATP2B2 (No Data); Atp2b2 (No Data); DKFZp686G08106 (No Data); Dkfzp686g08106 (No Data); DKFZp686M088 (No Data); Dkfzp686m088 (No Data); MXRA1 (No Data); Mxra1 (No Data); PMCA4 (Redirect -> Plasma membrane Ca2+ ATPase); Pmca4 (No Data); Plasma membrane Ca2+ ATPase (Unknown Data); [2]
LOX Manual Inspection (Page not found) Other Pages: Lysyl oxidase (Protein Template); LOX (Redirect -> liquid oxygen); MGC105112 (No Data); Mgc105112 (No Data); Liquid oxygen (Unknown Data); [3]
GRM1 Manual Inspection (Page not found) Other Pages: Glutamate receptor (Unknown Data); GRM1 (No Data); GPRC1A (No Data); Gprc1a (No Data); GRM1A (No Data); Grm1a (No Data); MGLUR1 (No Data); Mglur1 (No Data); MGLUR1A (No Data); Mglur1a (No Data); MGlu1 (No Data); Mglu1 (No Data); [4]
MPL Manual Inspection (Page not found) Other Pages: Myeloproliferative leukemia virus oncogene (No Data); MPL (DisAmbig); C-MPL (No Data); C-mpl (No Data); CD110 (No Data); Cd110 (No Data); MPLV (No Data); Mplv (No Data); TPOR (No Data); Tpor (No Data); [5]
HNRPC Manual Inspection (Page not found) Other Pages: Heterogeneous nuclear ribonucleoprotein C (No Data); HNRPC (No Data); C1 (DisAmbig); C2 (DisAmbig); HNRNP (No Data); Hnrnp (Redirect -> Heterogeneous ribonucleoprotein particle); MGC104306 (No Data); Mgc104306 (No Data); MGC105117 (No Data); Mgc105117 (No Data); MGC117353 (No Data); Mgc117353 (No Data); MGC131677 (No Data); Mgc131677 (No Data); SNRPC (No Data); Snrpc (No Data); HnRNPC (No Data); Hnrnpc (No Data); Heterogeneous ribonucleoprotein particle (Protein Template); [6]
LAMA3 Manual Inspection (Page not found) Other Pages: Laminin (Unknown Data); LAMA3 (No Data); E170 (DisAmbig); LAMNA (No Data); Lamna (Unknown Data); LOCS (No Data); Locs (Redirect -> Library of Congress); Lama3a (No Data); Library of Congress (Unknown Data); [7]
NOX1 Created Other Pages: NADPH oxidase 1 (No Data); NOX1 (No Data); MOX1 (No Data); Mox1 (No Data); GP91-2 (No Data); Gp91-2 (No Data); NOH-1 (No Data); Noh-1 (No Data); NOH1 (No Data); Noh1 (No Data); [8]
SIRPA Manual Inspection (Page not found) Other Pages: Signal-regulatory protein alpha (No Data); SIRPA (No Data); P84 (No Data); BIT (DisAmbig); Bit (Unknown Data); CD172A (No Data); Cd172a (No Data); MFR (DisAmbig); Mfr (No Data); MYD-1 (No Data); Myd-1 (No Data); PTPNS1 (No Data); Ptpns1 (No Data); SHPS-1 (No Data); Shps-1 (No Data); SHPS1 (No Data); Shps1 (No Data); SIRP (No Data); Sirp (No Data); SIRP-ALPHA-1 (No Data); Sirp-alpha-1 (No Data); SIRPalpha (No Data); Sirpalpha (No Data); SIRPalpha2 (No Data); Sirpalpha2 (No Data); [9]
CUTL1 Manual Inspection (Page not found) Other Pages: Cut-like 1 (No Data); CUTL1 (No Data); CASP (Unknown Data); Casp (No Data); CDP (DisAmbig); Cdp (No Data); COY1 (No Data); Coy1 (No Data); CUX (No Data); Cux (No Data); Nbla10317 (No Data); P100 (No Data); P110 (No Data); P200 (No Data); P75 (Redirect -> Low affinity nerve growth factor receptor); Low affinity nerve growth factor receptor (Protein Template); [10]
ANK1 Manual Inspection (Page not found) Other Pages: Ankyrin 1 (No Data); ANK1 (No Data); ANK (Redirect -> Air Nippon); Ank (No Data); SPH1 (No Data); Sph1 (No Data); SPH2 (No Data); Sph2 (No Data); Air Nippon (Unknown Data); [11]
ADH1C Created Other Pages: Alcohol dehydrogenase 1C (No Data); ADH1C (No Data); ADH3 (No Data); Adh3 (No Data); [12]
MLLT4 Created Other Pages: Myeloid/lymphoid or mixed-lineage leukemia ; translocated to (No Data); MLLT4 (No Data); AF-6 (No Data); Af-6 (No Data); AF6 (No Data); Af6 (No Data); AFADIN (No Data); Afadin (No Data); FLJ34371 (No Data); Flj34371 (No Data); RP3-431P23.3 (No Data); Rp3-431p23.3 (No Data); [13]
MAP2K3 Created Other Pages: Mitogen-activated protein kinase kinase 3 (No Data); MAP2K3 (No Data); MAPKK3 (No Data); Mapkk3 (No Data); MEK3 (No Data); Mek3 (No Data); MKK3 (No Data); Mkk3 (No Data); PRKMK3 (No Data); Prkmk3 (No Data); [14]
NTRK3 Created Other Pages: Neurotrophic tyrosine kinase (No Data); NTRK3 (No Data); TRKC (No Data); Trkc (No Data); Gp145(trkC) (No Data); Gp145(trkc) (No Data); [15]
GUSB Manual Inspection (Page not found) Other Pages: Glucuronidase (Protein Template); GUSB (No Data); FLJ39445 (No Data); Flj39445 (No Data); MPS7 (No Data); Mps7 (No Data); [16]
F11R Manual Inspection (Page not found) Other Pages: F11 receptor (No Data); F11R (No Data); KAT (Redirect -> Kat (band)); Kat (Human Name DisAmbig - not counted); CD321 (No Data); Cd321 (No Data); JAM (Redirect -> Jam (disambiguation)); Jam (Redirect -> Fruit preserves); JAM-1 (No Data); Jam-1 (No Data); JAM-A (No Data); Jam-a (No Data); JAM1 (No Data); Jam1 (No Data); JAMA (Redirect -> Jama); Jama (DisAmbig); JCAM (Redirect -> Jama'at al-Jihad al-Islami); Jcam (No Data); PAM-1 (No Data); Pam-1 (No Data); Kat (band) (Unknown Data); Jam (disambiguation) (DisAmbig); Fruit preserves (Unknown Data); Jama'at al-Jihad al-Islami (Unknown Data); [17]
ADORA1 Created Other Pages: Adenosine A1 receptor (No Data); ADORA1 (No Data); RDC7 (No Data); Rdc7 (No Data); [18]
APOC1 Created Other Pages: Apolipoprotein C-I (No Data); APOC1 (No Data); [19]
PKLR Manual Inspection (Page not found) Other Pages: Pyruvate kinase (Unknown Data); PKLR (No Data); PK1 (No Data); Pk1 (No Data); PKL (No Data); Pkl (No Data); RPK (Unknown Data); Rpk (No Data); [20]
ALDOA Manual Inspection (Page not found) Other Pages: Aldolase A (Unknown Data); ALDOA (No Data); ALDA (No Data); Alda (DisAmbig); MGC10942 (No Data); Mgc10942 (No Data); MGC17716 (No Data); Mgc17716 (No Data); MGC17767 (No Data); Mgc17767 (No Data); [21]
TUBB Manual Inspection (Page not found) Other Pages: Tubulin (Protein Template); TUBB (No Data); TUBB5 (No Data); Tubb5 (No Data); TUBB1 (No Data); Tubb1 (No Data); M40 (DisAmbig); MGC117247 (No Data); Mgc117247 (No Data); MGC16435 (No Data); Mgc16435 (No Data); [22]
PLEC1 Manual Inspection (Page not found) Other Pages: Plectin 1 (No Data); PLEC1 (No Data); HD1 (Redirect -> Euro1080); Hd1 (No Data); PCN (DisAmbig); Pcn (No Data); EBS1 (No Data); Ebs1 (No Data); EBSO (No Data); Ebso (No Data); PLEC1b (No Data); Plec1b (No Data); PLTN (No Data); Pltn (No Data); Euro1080 (Unknown Data); [23]
NRF1 Created Other Pages: Nuclear respiratory factor 1 (No Data); NRF1 (No Data); ALPHA-PAL (No Data); Alpha-pal (No Data); [24]
TPP1 Manual Inspection (Page not found) Other Pages: Tripeptidyl peptidase I (No Data); TPP1 (No Data); CLN2 (No Data); Cln2 (No Data); GIG1 (No Data); Gig1 (No Data); LPIC (Redirect -> Linux Professional Institute Certification); Lpic (No Data); MGC21297 (No Data); Mgc21297 (No Data); TPP I (No Data); Tpp i (No Data); Linux Professional Institute Certification (Unknown Data); [25]

Vebose Log - Date: 00:45, 9 November 2007 (UTC)[edit]

ADH1C[edit]

  • INFO: Beginning work on ADH1C... {November 8, 2007 4:06:09 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein ADH1C image.jpg {November 8, 2007 4:06:23 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 4:06:33 PM PST}
  • CREATED: Created new protein page: ADH1C {November 8, 2007 4:06:40 PM PST}

ADORA1[edit]

  • INFO: Beginning work on ADORA1... {November 8, 2007 4:06:40 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 4:07:33 PM PST}
  • CREATED: Created new protein page: ADORA1 {November 8, 2007 4:07:41 PM PST}

ALDOA[edit]

  • INFO: Beginning work on ALDOA... {November 8, 2007 4:07:41 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein ALDOA image.jpg {November 8, 2007 4:08:39 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:09:03 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_ALDOA_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ado.
 | PDB = {{PDB2|1ado}}, {{PDB2|1ald}}, {{PDB2|1ewd}}, {{PDB2|1ewe}}, {{PDB2|1ewg}}, {{PDB2|1ex5}}, {{PDB2|1j4e}}, {{PDB2|1zah}}, {{PDB2|1zai}}, {{PDB2|1zaj}}, {{PDB2|1zal}}, {{PDB2|2ald}}, {{PDB2|2ot0}}, {{PDB2|2ot1}}, {{PDB2|4ald}}, {{PDB2|6ald}}
 | Name = Aldolase A, fructose-bisphosphate
 | HGNCid = 414
 | Symbol = ALDOA
 | AltSymbols =; ALDA; MGC10942; MGC17716; MGC17767
 | OMIM = 103850
 | ECnumber =  
 | Homologene = 68996
 | MGIid = 87994
 | GeneAtlas_image1 = PBB_GE_ALDOA_200966_x_at_tn.png
 | GeneAtlas_image2 = PBB_GE_ALDOA_214687_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0004332 |text = fructose-bisphosphate aldolase activity}} {{GNF_GO|id=GO:0016829 |text = lyase activity}} 
 | Component = 
 | Process = {{GNF_GO|id=GO:0006000 |text = fructose metabolic process}} {{GNF_GO|id=GO:0006096 |text = glycolysis}} {{GNF_GO|id=GO:0006941 |text = striated muscle contraction}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 226
    | Hs_Ensembl = ENSG00000149925
    | Hs_RefseqProtein = NP_000025
    | Hs_RefseqmRNA = NM_000034
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 29971973
    | Hs_GenLoc_end = 29989235
    | Hs_Uniprot = P04075
    | Mm_EntrezGene = 11674
    | Mm_Ensembl = ENSMUSG00000030695
    | Mm_RefseqmRNA = NM_007438
    | Mm_RefseqProtein = NP_031464
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 126586384
    | Mm_GenLoc_end = 126590331
    | Mm_Uniprot = Q5FWB7
  }}
}}
'''Aldolase A, fructose-bisphosphate''', also known as '''ALDOA''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene product, Aldolase A (fructose-bisphosphate aldolase) is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants which encode the same protein.<ref>{{cite web | title = Entrez Gene: ALDOA aldolase A, fructose-bisphosphate| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=226| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

ANK1[edit]

  • INFO: Beginning work on ANK1... {November 8, 2007 4:09:03 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein ANK1 image.jpg {November 8, 2007 4:11:12 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:11:26 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_ANK1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1n11.
 | PDB = {{PDB2|1n11}}
 | Name = Ankyrin 1, erythrocytic
 | HGNCid = 492
 | Symbol = ANK1
 | AltSymbols =; ANK; SPH1; SPH2
 | OMIM = 182900
 | ECnumber =  
 | Homologene = 55427
 | MGIid = 88024
 | GeneAtlas_image1 = PBB_GE_ANK1_205389_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_ANK1_205390_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_ANK1_205391_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0008093 |text = cytoskeletal adaptor activity}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}} {{GNF_GO|id=GO:0030507 |text = spectrin binding}} 
 | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}} 
 | Process = {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0045199 |text = maintenance of epithelial cell polarity}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 286
    | Hs_Ensembl = ENSG00000029534
    | Hs_RefseqProtein = NP_000028
    | Hs_RefseqmRNA = NM_000037
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 41629902
    | Hs_GenLoc_end = 41873437
    | Hs_Uniprot = P16157
    | Mm_EntrezGene = 11733
    | Mm_Ensembl = ENSMUSG00000031543
    | Mm_RefseqmRNA = XM_981917
    | Mm_RefseqProtein = XP_987011
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 24440681
    | Mm_GenLoc_end = 24616041
    | Mm_Uniprot = Q0VGY9
  }}
}}
'''Ankyrin 1, erythrocytic''', also known as '''ANK1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains.  Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner.  Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation.  Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles.  Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis.  Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known.  Alternative polyadenylation accounting for the different sized erythrocytic ankyrin 1 mRNAs, has also been reported.  Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.<ref>{{cite web | title = Entrez Gene: ANK1 ankyrin 1, erythrocytic| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=286| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Bennett V, Baines AJ |title=Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. |journal=Physiol. Rev. |volume=81 |issue= 3 |pages= 1353-92 |year= 2001 |pmid= 11427698 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

APOC1[edit]

  • INFO: Beginning work on APOC1... {November 8, 2007 4:11:26 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein APOC1 image.jpg {November 8, 2007 4:11:42 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 4:11:50 PM PST}
  • CREATED: Created new protein page: APOC1 {November 8, 2007 4:11:57 PM PST}

ATP2B4[edit]

  • INFO: Beginning work on ATP2B4... {November 8, 2007 4:11:57 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:13:22 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = ATPase, Ca++ transporting, plasma membrane 4
 | HGNCid = 817
 | Symbol = ATP2B4
 | AltSymbols =; ATP2B2; DKFZp686G08106; DKFZp686M088; MXRA1; PMCA4
 | OMIM = 108732
 | ECnumber =  
 | Homologene = 48034
 | MGIid = 88111
 | GeneAtlas_image1 = PBB_GE_ATP2B4_205410_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_ATP2B4_212136_at_tn.png
 | GeneAtlas_image3 = PBB_GE_ATP2B4_212135_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0005388 |text = calcium-transporting ATPase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016820 |text = hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances}} 
 | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} 
 | Process = {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 493
    | Hs_Ensembl = ENSG00000058668
    | Hs_RefseqProtein = NP_001001396
    | Hs_RefseqmRNA = NM_001001396
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 201862312
    | Hs_GenLoc_end = 201979832
    | Hs_Uniprot = P23634
    | Mm_EntrezGene = 381290
    | Mm_Ensembl = ENSMUSG00000026463
    | Mm_RefseqmRNA = XM_981196
    | Mm_RefseqProtein = XP_986290
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 135523057
    | Mm_GenLoc_end = 135569692
    | Mm_Uniprot =  
  }}
}}
'''ATPase, Ca++ transporting, plasma membrane 4''', also known as '''ATP2B4''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: ATP2B4 ATPase, Ca++ transporting, plasma membrane 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=493| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Møller JV, Juul B, le Maire M |title=Structural organization, ion transport, and energy transduction of P-type ATPases. |journal=Biochim. Biophys. Acta |volume=1286 |issue= 1 |pages= 1-51 |year= 1996 |pmid= 8634322 |doi=  }}
*{{cite journal  | author=Strehler EE, Zacharias DA |title=Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps. |journal=Physiol. Rev. |volume=81 |issue= 1 |pages= 21-50 |year= 2001 |pmid= 11152753 |doi=  }}
*{{cite journal  | author=Strehler EE, Treiman M |title=Calcium pumps of plasma membrane and cell interior. |journal=Curr. Mol. Med. |volume=4 |issue= 3 |pages= 323-35 |year= 2004 |pmid= 15101689 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

CUTL1[edit]

  • INFO: Beginning work on CUTL1... {November 8, 2007 4:14:39 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:15:07 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Cut-like 1, CCAAT displacement protein (Drosophila)
 | HGNCid = 2557
 | Symbol = CUTL1
 | AltSymbols =; CASP; CDP; COY1; CUX; Nbla10317; p100; p110; p200; p75
 | OMIM = 116896
 | ECnumber =  
 | Homologene = 22551
 | MGIid = 88568
 | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1523
    | Hs_Ensembl = ENSG00000160967
    | Hs_RefseqProtein = NP_001904
    | Hs_RefseqmRNA = NM_001913
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 101246011
    | Hs_GenLoc_end = 101713969
    | Hs_Uniprot = P39880
    | Mm_EntrezGene = 13047
    | Mm_Ensembl = ENSMUSG00000029705
    | Mm_RefseqmRNA = NM_009986
    | Mm_RefseqProtein = NP_034116
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 136532763
    | Mm_GenLoc_end = 136851889
    | Mm_Uniprot = P70381
  }}
}}
'''Cut-like 1, CCAAT displacement protein (Drosophila)''', also known as '''CUTL1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref>{{cite web | title = Entrez Gene: CUTL1 cut-like 1, CCAAT displacement protein (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1523| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Ottolenghi S, Mantovani R, Nicolis S, ''et al.'' |title=DNA sequences regulating human globin gene transcription in nondeletional hereditary persistence of fetal hemoglobin. |journal=Hemoglobin |volume=13 |issue= 6 |pages= 523-41 |year= 1990 |pmid= 2481658 |doi=  }}
*{{cite journal  | author=Nepveu A |title=Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation, cell growth and development. |journal=Gene |volume=270 |issue= 1-2 |pages= 1-15 |year= 2001 |pmid= 11403998 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

F11R[edit]

  • INFO: Beginning work on F11R... {November 8, 2007 4:32:46 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein F11R image.jpg {November 8, 2007 4:33:51 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:34:22 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_F11R_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nbq.
 | PDB = {{PDB2|1nbq}}
 | Name = F11 receptor
 | HGNCid = 14685
 | Symbol = F11R
 | AltSymbols =; KAT; CD321; JAM; JAM-1; JAM-A; JAM1; JAMA; JCAM; PAM-1
 | OMIM = 605721
 | ECnumber =  
 | Homologene = 14255
 | MGIid = 1321398
 | GeneAtlas_image1 = PBB_GE_F11R_221664_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_F11R_222354_at_tn.png
 | Function = {{GNF_GO|id=GO:0004792 |text = thiosulfate sulfurtransferase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005923 |text = tight junction}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 50848
    | Hs_Ensembl = ENSG00000158769
    | Hs_RefseqProtein = NP_058642
    | Hs_RefseqmRNA = NM_016946
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 159231625
    | Hs_GenLoc_end = 159275404
    | Hs_Uniprot = Q9Y624
    | Mm_EntrezGene = 16456
    | Mm_Ensembl = ENSMUSG00000038235
    | Mm_RefseqmRNA = NM_172647
    | Mm_RefseqProtein = NP_766235
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 173274236
    | Mm_GenLoc_end = 173301268
    | Mm_Uniprot = Q8VC39
  }}
}}
'''F11 receptor''', also known as '''F11R''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple transcript variants encoding two different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: F11R F11 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50848| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Muller WA |title=Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. |journal=Trends Immunol. |volume=24 |issue= 6 |pages= 327-34 |year= 2003 |pmid= 12810109 |doi=  }}
*{{cite journal  | author=Bazzoni G |title=The JAM family of junctional adhesion molecules. |journal=Curr. Opin. Cell Biol. |volume=15 |issue= 5 |pages= 525-30 |year= 2004 |pmid= 14519386 |doi=  }}
*{{cite journal  | author=Naik UP, Eckfeld K |title=Junctional adhesion molecule 1 (JAM-1). |journal=J. Biol. Regul. Homeost. Agents |volume=17 |issue= 4 |pages= 341-7 |year= 2004 |pmid= 15065765 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

GRM1[edit]

  • INFO: Beginning work on GRM1... {November 8, 2007 4:15:07 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein GRM1 image.jpg {November 8, 2007 4:16:19 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:16:36 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_GRM1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ewk.
 | PDB = {{PDB2|1ewk}}, {{PDB2|1ewt}}, {{PDB2|1ewv}}, {{PDB2|1isr}}, {{PDB2|1iss}}
 | Name = Glutamate receptor, metabotropic 1
 | HGNCid = 4593
 | Symbol = GRM1
 | AltSymbols =; GPRC1A; GRM1A; MGLUR1; MGLUR1A; mGlu1
 | OMIM = 604473
 | ECnumber =  
 | Homologene = 649
 | MGIid = 1351338
 | GeneAtlas_image1 = PBB_GE_GRM1_207299_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_GRM1_210939_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_GRM1_210940_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}} 
 | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030425 |text = dendrite}} 
 | Process = {{GNF_GO|id=GO:0000186 |text = activation of MAPKK activity}} {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0043408 |text = regulation of MAPKKK cascade}} {{GNF_GO|id=GO:0051930 |text = regulation of sensory perception of pain}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2911
    | Hs_Ensembl = ENSG00000152822
    | Hs_RefseqProtein = NP_000829
    | Hs_RefseqmRNA = NM_000838
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 146390611
    | Hs_GenLoc_end = 146800427
    | Hs_Uniprot = Q13255
    | Mm_EntrezGene = 14816
    | Mm_Ensembl = ENSMUSG00000019828
    | Mm_RefseqmRNA = XM_976537
    | Mm_RefseqProtein = XP_981631
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 10378793
    | Mm_GenLoc_end = 10772495
    | Mm_Uniprot = Q3V0U2
  }}
}}
'''Glutamate receptor, metabotropic 1''', also known as '''GRM1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors.  Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties.  Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C.  Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.   Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of the GRM1 gene have been described but their full-length nature has not been determined.<ref>{{cite web | title = Entrez Gene: GRM1 glutamate receptor, metabotropic 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2911| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Bockaert J, Pin JP |title=Molecular tinkering of G protein-coupled receptors: an evolutionary success. |journal=EMBO J. |volume=18 |issue= 7 |pages= 1723-9 |year= 1999 |pmid= 10202136 |doi= 10.1093/emboj/18.7.1723 }}
}}
{{refend}}

{{protein-stub}}
 

GUSB[edit]

  • INFO: Beginning work on GUSB... {November 8, 2007 4:16:36 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein GUSB image.jpg {November 8, 2007 4:17:08 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:17:20 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_GUSB_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bhg.
 | PDB = {{PDB2|1bhg}}
 | Name = Glucuronidase, beta
 | HGNCid = 4696
 | Symbol = GUSB
 | AltSymbols =; FLJ39445; MPS7
 | OMIM = 253220
 | ECnumber =  
 | Homologene = 37271
 | MGIid = 95872
 | GeneAtlas_image1 = PBB_GE_GUSB_202605_at_tn.png
 | Function = {{GNF_GO|id=GO:0004566 |text = beta-glucuronidase activity}} {{GNF_GO|id=GO:0043169 |text = cation binding}} 
 | Component = {{GNF_GO|id=GO:0005764 |text = lysosome}} 
 | Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006027 |text = glycosaminoglycan catabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2990
    | Hs_Ensembl = ENSG00000169919
    | Hs_RefseqProtein = NP_000172
    | Hs_RefseqmRNA = NM_000181
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 65063110
    | Hs_GenLoc_end = 65084635
    | Hs_Uniprot = P08236
    | Mm_EntrezGene = 110006
    | Mm_Ensembl = ENSMUSG00000025534
    | Mm_RefseqmRNA = NM_010368
    | Mm_RefseqProtein = NP_034498
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 130273725
    | Mm_GenLoc_end = 130287564
    | Mm_Uniprot = Q3TW82
  }}
}}
'''Glucuronidase, beta''', also known as '''GUSB''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

HIPK2[edit]

  • INFO: Beginning work on HIPK2... {November 8, 2007 4:32:26 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 4:32:39 PM PST}
  • CREATED: Created new protein page: HIPK2 {November 8, 2007 4:32:46 PM PST}

HNRPC[edit]

  • INFO: Beginning work on HNRPC... {November 8, 2007 4:17:20 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein HNRPC image.jpg {November 8, 2007 4:17:33 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:17:57 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_HNRPC_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wf2.
 | PDB = {{PDB2|1wf2}}
 | Name = Heterogeneous nuclear ribonucleoprotein C (C1/C2)
 | HGNCid = 5035
 | Symbol = HNRPC
 | AltSymbols =; C1; C2; HNRNP; MGC104306; MGC105117; MGC117353; MGC131677; SNRPC; hnRNPC
 | OMIM = 164020
 | ECnumber =  
 | Homologene = 74524
 | MGIid = 107795
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} 
 | Process = {{GNF_GO|id=GO:0000398 |text = nuclear mRNA splicing, via spliceosome}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3183
    | Hs_Ensembl =  
    | Hs_RefseqProtein = NP_001070910
    | Hs_RefseqmRNA = NM_001077442
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 15381
    | Mm_Ensembl = ENSMUSG00000060373
    | Mm_RefseqmRNA = NM_016884
    | Mm_RefseqProtein = NP_058580
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 50995502
    | Mm_GenLoc_end = 51025955
    | Mm_Uniprot = Q3U6P5
  }}
}}
'''Heterogeneous nuclear ribonucleoprotein C (C1/C2)''', also known as '''HNRPC''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: HNRPC heterogeneous nuclear ribonucleoprotein C (C1/C2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3183| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

LAMA3[edit]

  • INFO: Beginning work on LAMA3... {November 8, 2007 4:17:57 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:19:41 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Laminin, alpha 3
 | HGNCid = 6483
 | Symbol = LAMA3
 | AltSymbols =; E170; LAMNA; LOCS; lama3a
 | OMIM = 600805
 | ECnumber =  
 | Homologene = 18279
 | MGIid = 99909
 | GeneAtlas_image1 = PBB_GE_LAMA3_203726_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_LAMA3_gnf1h02350_at_tn.png
 | GeneAtlas_image3 = PBB_GE_LAMA3_gnf1h02351_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} 
 | Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0005606 |text = laminin-1 complex}} 
 | Process = {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}} {{GNF_GO|id=GO:0045995 |text = regulation of embryonic development}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3909
    | Hs_Ensembl = ENSG00000053747
    | Hs_RefseqProtein = NP_000218
    | Hs_RefseqmRNA = NM_000227
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 19523560
    | Hs_GenLoc_end = 19789025
    | Hs_Uniprot = Q16787
    | Mm_EntrezGene = 16774
    | Mm_Ensembl = ENSMUSG00000024421
    | Mm_RefseqmRNA = XM_140451
    | Mm_RefseqProtein = XP_140451
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 12477560
    | Mm_GenLoc_end = 12725832
    | Mm_Uniprot = Q3UU65
  }}
}}
'''Laminin, alpha 3''', also known as '''LAMA3''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 chain of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: LAMA3 laminin, alpha 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3909| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Timpl R |title=Macromolecular organization of basement membranes. |journal=Curr. Opin. Cell Biol. |volume=8 |issue= 5 |pages= 618-24 |year= 1997 |pmid= 8939648 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

LOX[edit]

  • INFO: Beginning work on LOX... {November 8, 2007 4:19:41 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:20:50 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Lysyl oxidase
 | HGNCid = 6664
 | Symbol = LOX
 | AltSymbols =; MGC105112
 | OMIM = 153455
 | ECnumber =  
 | Homologene = 1741
 | MGIid = 96817
 | GeneAtlas_image1 = PBB_GE_LOX_215446_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_LOX_204298_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_LOX_213640_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004720 |text = protein-lysine 6-oxidase activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005581 |text = collagen}} 
 | Process = {{GNF_GO|id=GO:0006464 |text = protein modification process}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4015
    | Hs_Ensembl = ENSG00000113083
    | Hs_RefseqProtein = NP_002308
    | Hs_RefseqmRNA = NM_002317
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 121429918
    | Hs_GenLoc_end = 121441853
    | Hs_Uniprot = P28300
    | Mm_EntrezGene = 16948
    | Mm_Ensembl = ENSMUSG00000024529
    | Mm_RefseqmRNA = NM_010728
    | Mm_RefseqProtein = NP_034858
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 52646159
    | Mm_GenLoc_end = 52654698
    | Mm_Uniprot = Q3TLP7
  }}
}}
'''Lysyl oxidase''', also known as '''LOX''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression.<ref>{{cite web | title = Entrez Gene: LOX lysyl oxidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4015| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Csiszar K |title=Lysyl oxidases: a novel multifunctional amine oxidase family. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=70 |issue=  |pages= 1-32 |year= 2001 |pmid= 11642359 |doi=  }}
*{{cite journal  | author=Kagan HM, Li W |title=Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. |journal=J. Cell. Biochem. |volume=88 |issue= 4 |pages= 660-72 |year= 2003 |pmid= 12577300 |doi= 10.1002/jcb.10413 }}
}}
{{refend}}

{{protein-stub}}
 

MAP2K3[edit]

  • INFO: Beginning work on MAP2K3... {November 8, 2007 4:30:09 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 4:30:35 PM PST}
  • CREATED: Created new protein page: MAP2K3 {November 8, 2007 4:30:42 PM PST}

MLLT4[edit]

  • INFO: Beginning work on MLLT4... {November 8, 2007 4:20:50 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein MLLT4 image.jpg {November 8, 2007 4:22:11 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 4:22:28 PM PST}
  • CREATED: Created new protein page: MLLT4 {November 8, 2007 4:22:35 PM PST}

MPL[edit]

  • INFO: Beginning work on MPL... {November 8, 2007 4:22:35 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:23:56 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Myeloproliferative leukemia virus oncogene
 | HGNCid = 7217
 | Symbol = MPL
 | AltSymbols =; C-MPL; CD110; MPLV; TPOR
 | OMIM = 159530
 | ECnumber =  
 | Homologene = 7845
 | MGIid = 97076
 | GeneAtlas_image1 = PBB_GE_MPL_211903_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_MPL_207550_at_tn.png
 | GeneAtlas_image3 = PBB_GE_MPL_216825_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004896 |text = hematopoietin/interferon-class (D200-domain) cytokine receptor activity}} 
 | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4352
    | Hs_Ensembl = ENSG00000117400
    | Hs_RefseqProtein = NP_005364
    | Hs_RefseqmRNA = NM_005373
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 43576065
    | Hs_GenLoc_end = 43591030
    | Hs_Uniprot = P40238
    | Mm_EntrezGene = 17480
    | Mm_Ensembl = ENSMUSG00000006389
    | Mm_RefseqmRNA = NM_010823
    | Mm_RefseqProtein = NP_034953
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 117940347
    | Mm_GenLoc_end = 117955445
    | Mm_Uniprot = Q3ZB69
  }}
}}
'''Myeloproliferative leukemia virus oncogene''', also known as '''MPL''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.<ref>{{cite web | title = Entrez Gene: MPL myeloproliferative leukemia virus oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4352| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Kato T, Matsumoto A, Ogami K, ''et al.'' |title=Native thrombopoietin: structure and function. |journal=Stem Cells |volume=16 |issue= 5 |pages= 322-8 |year= 1999 |pmid= 9766811 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

NOX1[edit]

  • INFO: Beginning work on NOX1... {November 8, 2007 4:30:42 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 4:32:19 PM PST}
  • CREATED: Created new protein page: NOX1 {November 8, 2007 4:32:26 PM PST}

NRF1[edit]

  • INFO: Beginning work on NRF1... {November 8, 2007 4:23:56 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 4:25:49 PM PST}
  • CREATED: Created new protein page: NRF1 {November 8, 2007 4:25:56 PM PST}

NTRK3[edit]

  • INFO: Beginning work on NTRK3... {November 8, 2007 4:25:56 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein NTRK3 image.jpg {November 8, 2007 4:27:51 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 4:28:03 PM PST}
  • CREATED: Created new protein page: NTRK3 {November 8, 2007 4:28:11 PM PST}

PKLR[edit]

  • INFO: Beginning work on PKLR... {November 8, 2007 4:28:11 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein PKLR image.jpg {November 8, 2007 4:29:21 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:29:36 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PKLR_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1liu.
 | PDB = {{PDB2|1liu}}, {{PDB2|1liw}}, {{PDB2|1lix}}, {{PDB2|1liy}}
 | Name = Pyruvate kinase, liver and RBC
 | HGNCid = 9020
 | Symbol = PKLR
 | AltSymbols =; PK1; PKL; RPK
 | OMIM = 609712
 | ECnumber =  
 | Homologene = 37286
 | MGIid = 97604
 | GeneAtlas_image1 = PBB_GE_PKLR_207858_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_PKLR_210451_at_tn.png
 | GeneAtlas_image3 = PBB_GE_PKLR_222078_at_tn.png
 | Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004743 |text = pyruvate kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} 
 | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} 
 | Process = {{GNF_GO|id=GO:0006096 |text = glycolysis}} {{GNF_GO|id=GO:0051707 |text = response to other organism}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5313
    | Hs_Ensembl = ENSG00000143627
    | Hs_RefseqProtein = NP_000289
    | Hs_RefseqmRNA = NM_000298
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 153526254
    | Hs_GenLoc_end = 153537849
    | Hs_Uniprot = P30613
    | Mm_EntrezGene = 18770
    | Mm_Ensembl = ENSMUSG00000041237
    | Mm_RefseqmRNA = NM_013631
    | Mm_RefseqProtein = NP_038659
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 89222069
    | Mm_GenLoc_end = 89231560
    | Mm_Uniprot = Q3UEH4
  }}
}}
'''Pyruvate kinase, liver and RBC''', also known as '''PKLR''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a pyruvate kinase that catalyzes the production of phohsphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Alternatively spliced transcript variants encoding distinct isoforms have been described.<ref>{{cite web | title = Entrez Gene: PKLR pyruvate kinase, liver and RBC| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5313| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Beutler E, Baronciani L |title=Mutations in pyruvate kinase. |journal=Hum. Mutat. |volume=7 |issue= 1 |pages= 1-6 |year= 1996 |pmid= 8664896 |doi= 10.1002/(SICI)1098-1004(1996)7:1&lt;1::AID-HUMU1&gt;3.0.CO;2-H }}
*{{cite journal  | author=Baronciani L, Bianchi P, Zanella A |title=Hematologically important mutations: red cell pyruvate kinase (2nd update). |journal=Blood Cells Mol. Dis. |volume=24 |issue= 3 |pages= 273-9 |year= 1999 |pmid= 10087985 |doi= 10.1006/bcmd.1998.0193 }}
*{{cite journal  | author=Zanella A, Fermo E, Bianchi P, ''et al.'' |title=Pyruvate kinase deficiency: the genotype-phenotype association. |journal=Blood Rev. |volume=21 |issue= 4 |pages= 217-31 |year= 2007 |pmid= 17360088 |doi= 10.1016/j.blre.2007.01.001 }}
}}
{{refend}}

{{protein-stub}}
 

PLEC1[edit]

  • INFO: Beginning work on PLEC1... {November 8, 2007 4:29:36 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein PLEC1 image.jpg {November 8, 2007 4:29:49 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:30:09 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PLEC1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mb8.
 | PDB = {{PDB2|1mb8}}, {{PDB2|1sh5}}, {{PDB2|1sh6}}, {{PDB2|2odu}}, {{PDB2|2odv}}
 | Name = Plectin 1, intermediate filament binding protein 500kDa
 | HGNCid = 9069
 | Symbol = PLEC1
 | AltSymbols =; HD1; PCN; EBS1; EBSO; PLEC1b; PLTN
 | OMIM = 601282
 | ECnumber =  
 | Homologene = 384
 | MGIid = 1277961
 | Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0008307 |text = structural constituent of muscle}} 
 | Component = {{GNF_GO|id=GO:0005626 |text = insoluble fraction}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005882 |text = intermediate filament}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0043292 |text = contractile fiber}} 
 | Process = {{GNF_GO|id=GO:0007016 |text = cytoskeletal anchoring}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5339
    | Hs_Ensembl =  
    | Hs_RefseqProtein = NP_000436
    | Hs_RefseqmRNA = NM_000445
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 18810
    | Mm_Ensembl = ENSMUSG00000022565
    | Mm_RefseqmRNA = XM_994758
    | Mm_RefseqProtein = XP_999852
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 75998231
    | Mm_GenLoc_end = 76058633
    | Mm_Uniprot = Q6S390
  }}
}}
'''Plectin 1, intermediate filament binding protein 500kDa''', also known as '''PLEC1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The product of this gene belongs to the plakin or cytolinker family of genes. The encoded protein is involved in cytoskeleton-membrane attachment in epithelial cells, muscle, and other tissues. It also may regulate changes of lymphocyte cytoarchitecture during polarization and extravasation. This gene has alternative splicing of different 5' exons to the first constant exon, which generates transcript variants that encode distinct isoforms.<ref>{{cite web | title = Entrez Gene: PLEC1 plectin 1, intermediate filament binding protein 500kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5339| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Pfendner E, Rouan F, Uitto J |title=Progress in epidermolysis bullosa: the phenotypic spectrum of plectin mutations. |journal=Exp. Dermatol. |volume=14 |issue= 4 |pages= 241-9 |year= 2005 |pmid= 15810881 |doi= 10.1111/j.0906-6705.2005.00324.x }}
}}
{{refend}}

{{protein-stub}}
 

SIRPA[edit]

  • INFO: Beginning work on SIRPA... {November 8, 2007 4:34:22 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:36:24 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Signal-regulatory protein alpha
 | HGNCid = 9662
 | Symbol = SIRPA
 | AltSymbols =; P84; BIT; CD172A; MFR; MYD-1; PTPNS1; SHPS-1; SHPS1; SIRP; SIRP-ALPHA-1; SIRPalpha; SIRPalpha2
 | OMIM = 602461
 | ECnumber =  
 | Homologene = 7246
 | MGIid = 108563
 | GeneAtlas_image1 = PBB_GE_SIRPA_202896_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_SIRPA_202895_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_SIRPA_202897_at_tn.png
 | Function = 
 | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 140885
    | Hs_Ensembl = ENSG00000198053
    | Hs_RefseqProtein = NP_001035111
    | Hs_RefseqmRNA = NM_001040022
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 1823425
    | Hs_GenLoc_end = 1868543
    | Hs_Uniprot = P78324
    | Mm_EntrezGene = 19261
    | Mm_Ensembl = ENSMUSG00000037902
    | Mm_RefseqmRNA = NM_007547
    | Mm_RefseqProtein = NP_031573
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 129284355
    | Mm_GenLoc_end = 129323669
    | Mm_Uniprot = P97797
  }}
}}
'''Signal-regulatory protein alpha''', also known as '''SIRPA''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.<ref>{{cite web | title = Entrez Gene: SIRPA signal-regulatory protein alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140885| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Oldenborg PA |title=Role of CD47 in erythroid cells and in autoimmunity. |journal=Leuk. Lymphoma |volume=45 |issue= 7 |pages= 1319-27 |year= 2004 |pmid= 15359629 |doi= 10.1080/1042819042000201989 }}
}}
{{refend}}

{{protein-stub}}
 

TPP1[edit]

  • INFO: Beginning work on TPP1... {November 8, 2007 4:13:22 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:14:39 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Tripeptidyl peptidase I
 | HGNCid = 2073
 | Symbol = TPP1
 | AltSymbols =; CLN2; GIG1; LPIC; MGC21297; TPP I
 | OMIM = 607998
 | ECnumber =  
 | Homologene = 335
 | MGIid = 1336194
 | GeneAtlas_image1 = PBB_GE_TPP1_200743_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_TPP1_200742_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_TPP1_214196_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004177 |text = aminopeptidase activity}} {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019131 |text = tripeptidyl-peptidase I activity}} 
 | Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005764 |text = lysosome}} 
 | Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0007040 |text = lysosome organization and biogenesis}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030163 |text = protein catabolic process}} {{GNF_GO|id=GO:0043171 |text = peptide catabolic process}} {{GNF_GO|id=GO:0045453 |text = bone resorption}} {{GNF_GO|id=GO:0045862 |text = positive regulation of proteolysis}} {{GNF_GO|id=GO:0050885 |text = regulation of balance}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1200
    | Hs_Ensembl = ENSG00000166340
    | Hs_RefseqProtein = NP_000382
    | Hs_RefseqmRNA = NM_000391
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 6590576
    | Hs_GenLoc_end = 6597236
    | Hs_Uniprot = O14773
    | Mm_EntrezGene = 12751
    | Mm_Ensembl = ENSMUSG00000030894
    | Mm_RefseqmRNA = NM_009906
    | Mm_RefseqProtein = NP_034036
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 105618668
    | Mm_GenLoc_end = 105626028
    | Mm_Uniprot = Q3TDY6
  }}
}}
'''Tripeptidyl peptidase I''', also known as '''TPP1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.<ref>{{cite web | title = Entrez Gene: TPP1 tripeptidyl peptidase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1200| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Mole SE, Mitchison HM, Munroe PB |title=Molecular basis of the neuronal ceroid lipofuscinoses: mutations in CLN1, CLN2, CLN3, and CLN5. |journal=Hum. Mutat. |volume=14 |issue= 3 |pages= 199-215 |year= 1999 |pmid= 10477428 |doi= 10.1002/(SICI)1098-1004(1999)14:3<199::AID-HUMU3>3.0.CO;2-A }}
*{{cite journal  | author=Dawson G, Cho S |title=Batten's disease: clues to neuronal protein catabolism in lysosomes. |journal=J. Neurosci. Res. |volume=60 |issue= 2 |pages= 133-40 |year= 2000 |pmid= 10740217 |doi=  }}
*{{cite journal  | author=Hofmann SL, Atashband A, Cho SK, ''et al.'' |title=Neuronal ceroid lipofuscinoses caused by defects in soluble lysosomal enzymes (CLN1 and CLN2). |journal=Curr. Mol. Med. |volume=2 |issue= 5 |pages= 423-37 |year= 2003 |pmid= 12125808 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

TUBB[edit]

  • INFO: Beginning work on TUBB... {November 8, 2007 4:36:24 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein TUBB image.jpg {November 8, 2007 4:36:37 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 4:36:55 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_TUBB_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ffx.
 | PDB = {{PDB2|1ffx}}, {{PDB2|1ia0}}, {{PDB2|1jff}}, {{PDB2|1sa0}}, {{PDB2|1sa1}}, {{PDB2|1tub}}, {{PDB2|1tvk}}, {{PDB2|1z2b}}, {{PDB2|2hxf}}, {{PDB2|2hxh}}
 | Name = Tubulin, beta
 | HGNCid = 20778
 | Symbol = TUBB
 | AltSymbols =; TUBB5; TUBB1; M40; MGC117247; MGC16435; OK/SW-cl.56
 | OMIM = 191130
 | ECnumber =  
 | Homologene = 69099
 | MGIid = 107812
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0042288 |text = MHC class I protein binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0043234 |text = protein complex}} 
 | Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0042267 |text = natural killer cell mediated cytotoxicity}} {{GNF_GO|id=GO:0051227 |text = spindle assembly}} {{GNF_GO|id=GO:0051258 |text = protein polymerization}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 203068
    | Hs_Ensembl =  
    | Hs_RefseqProtein = NP_821133
    | Hs_RefseqmRNA = NM_178014
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 22154
    | Mm_Ensembl = ENSMUSG00000001525
    | Mm_RefseqmRNA = NM_011655
    | Mm_RefseqProtein = NP_035785
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 35442860
    | Mm_GenLoc_end = 35446285
    | Mm_Uniprot = Q3TFB6
  }}
}}
'''Tubulin, beta''', also known as '''TUBB''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Berrieman HK, Lind MJ, Cawkwell L |title=Do beta-tubulin mutations have a role in resistance to chemotherapy? |journal=Lancet Oncol. |volume=5 |issue= 3 |pages= 158-64 |year= 2004 |pmid= 15003198 |doi= 10.1016/S1470-2045(04)01411-1 }}
}}
{{refend}}

{{protein-stub}}
 

end log.