User:ProteinBoxBot/PBB Log Wiki 11-8-2007 A-8

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Log file for Protein Box Bot[edit]

Log page index: User:ProteinBoxBot/PBB_Log_Index

Protein Status Quick Log - Date: 23:11, 8 November 2007 (UTC)[edit]

Proteins without matches (19)[edit]

RACGAP1 ING1 SERPINB2 FLI1 MAP2K6
PRKCH KPNA5 PRG2 PSMA1 GRIA1
GTF2I EFNB1 PABPC1 ERCC1 GYPA
NEUROD1 EIF5A MAX GPI

Proteins with a High Potential Match (6)[edit]

ACAN FOLH1 AIRE NPC1 IL17A
APBB1

Created (9)[edit]

RACGAP1 FLI1 MAP2K6 KPNA5 EFNB1
PABPC1 ERCC1 NEUROD1 EIF5A

Manual Inspection (Page not found) (16)[edit]

ING1 SERPINB2 ACAN PRKCH PRG2
PSMA1 FOLH1 GRIA1 GTF2I AIRE
NPC1 GYPA IL17A MAX APBB1
GPI


Protein Status Grid - Date: 23:11, 8 November 2007 (UTC)[edit]

HUGO Symbol Action Summary Target page(s) WP Symbol Search
RACGAP1 Created Other Pages: Rac GTPase activating protein 1 (No Data); RACGAP1 (No Data); HsCYK-4 (No Data); Hscyk-4 (No Data); ID-GAP (No Data); Id-gap (No Data); MgcRacGAP (No Data); Mgcracgap (No Data); [1]
ING1 Manual Inspection (Page not found) Other Pages: Inhibitor of growth family (No Data); ING1 (No Data); P24ING1c (No Data); P24ing1c (No Data); P33 (No Data); P33ING1 (No Data); P33ing1 (No Data); P33ING1b (No Data); P33ing1b (No Data); P47 (Redirect -> P-47 Thunderbolt); P47ING1a (No Data); P47ing1a (No Data); P-47 Thunderbolt (Unknown Data); [2]
SERPINB2 Manual Inspection (Page not found) Other Pages: Serpin peptidase inhibitor (Redirect -> Serpin); SERPINB2 (No Data); PAI (DisAmbig); Pai (DisAmbig); HsT1201 (No Data); Hst1201 (No Data); PAI-2 (No Data); Pai-2 (No Data); PAI2 (No Data); Pai2 (No Data); PLANH2 (No Data); Planh2 (No Data); Serpin (Unknown Data); [3]
ACAN Manual Inspection (Page not found) Other Pages: Aggrecan (Protein Template); ACAN (Redirect -> Advisory Committee on Antarctic Names); AGC1 (No Data); Agc1 (No Data); AGCAN (No Data); Agcan (No Data); CSPG1 (No Data); Cspg1 (No Data); CSPGCP (No Data); Cspgcp (No Data); MSK16 (No Data); Msk16 (No Data); SEDK (No Data); Sedk (No Data); Advisory Committee on Antarctic Names (Unknown Data); [4]
FLI1 Created Other Pages: Friend leukemia virus integration 1 (No Data); FLI1 (No Data); EWSR2 (No Data); Ewsr2 (No Data); SIC-1 (No Data); Sic-1 (No Data); [5]
MAP2K6 Created Other Pages: Mitogen-activated protein kinase kinase 6 (No Data); MAP2K6 (No Data); MAPKK6 (No Data); Mapkk6 (No Data); MEK6 (No Data); Mek6 (No Data); MKK6 (No Data); Mkk6 (No Data); PRKMK6 (No Data); Prkmk6 (No Data); SAPKK3 (No Data); Sapkk3 (No Data); [6]
PRKCH Manual Inspection (Page not found) Other Pages: Protein kinase C (Unknown Data); PRKCH (No Data); MGC26269 (No Data); Mgc26269 (No Data); MGC5363 (No Data); Mgc5363 (No Data); PKC-L (No Data); Pkc-l (No Data); PKCL (No Data); Pkcl (No Data); PRKCL (No Data); Prkcl (No Data); NPKC-eta (No Data); Npkc-eta (No Data); [7]
KPNA5 Created Other Pages: Karyopherin alpha 5 (No Data); KPNA5 (No Data); IPOA6 (No Data); Ipoa6 (No Data); SRP6 (No Data); Srp6 (No Data); [8]
PRG2 Manual Inspection (Page not found) Other Pages: Proteoglycan 2 (No Data); PRG2 (No Data); MBP (DisAmbig); Mbp (Redirect -> MBP); BMPG (No Data); Bmpg (No Data); MGC14537 (No Data); Mgc14537 (No Data); [9]
PSMA1 Manual Inspection (Page not found) Other Pages: Proteasome subunit (No Data); PSMA1 (No Data); HC2 (No Data); Hc2 (No Data); MGC14542 (No Data); Mgc14542 (No Data); MGC14575 (No Data); Mgc14575 (No Data); MGC14751 (No Data); Mgc14751 (No Data); MGC1667 (No Data); Mgc1667 (No Data); MGC21459 (No Data); Mgc21459 (No Data); MGC22853 (No Data); Mgc22853 (No Data); MGC23915 (No Data); Mgc23915 (No Data); NU (Redirect -> Nu); Nu (DisAmbig); PROS30 (No Data); Pros30 (No Data); [10]
FOLH1 Manual Inspection (Page not found) Other Pages: Folate hydrolase 1 (Redirect -> Glutamate carboxypeptidase II); FOLH1 (No Data); PSM (DisAmbig); Psm (No Data); FGCP (No Data); Fgcp (No Data); FOLH (No Data); Folh (No Data); GCP2 (No Data); Gcp2 (No Data); GCPII (Redirect -> Glutamate carboxypeptidase II); Gcpii (No Data); NAALAD1 (No Data); Naalad1 (No Data); NAALAdase (No Data); Naaladase (No Data); PSMA (No Data); Psma (No Data); MGCP (Redirect -> Media Gateway Control Protocol); Mgcp (No Data); Glutamate carboxypeptidase II (Protein Template); Media Gateway Control Protocol (Unknown Data); [11]
GRIA1 Manual Inspection (Page not found) Other Pages: Glutamate receptor (Unknown Data); GRIA1 (No Data); GLUH1 (No Data); Gluh1 (No Data); GLUR1 (No Data); Glur1 (No Data); GLURA (No Data); Glura (No Data); HBGR1 (No Data); Hbgr1 (No Data); MGC133252 (No Data); Mgc133252 (No Data); [12]
GTF2I Manual Inspection (Page not found) Other Pages: General transcription factor II (No Data); GTF2I (No Data); WBS (DisAmbig); Wbs (No Data); BAP-135 (No Data); Bap-135 (No Data); BAP135 (No Data); Bap135 (No Data); BTKAP1 (No Data); Btkap1 (No Data); DIWS (No Data); Diws (No Data); IB291 (No Data); Ib291 (No Data); SPIN (Redirect -> Spin); Spin (DisAmbig); TFII-I (No Data); Tfii-i (No Data); WBSCR6 (No Data); Wbscr6 (No Data); [13]
AIRE Manual Inspection (Page not found) Other Pages: Autoimmune regulator (Protein Template); AIRE (No Data); AIRE1 (No Data); Aire1 (No Data); APECED (Redirect -> Autoimmune polyendocrine syndrome); Apeced (No Data); APS1 (No Data); Aps1 (No Data); APSI (No Data); Apsi (No Data); PGA1 (No Data); Pga1 (No Data); Autoimmune polyendocrine syndrome (Unknown Data); [14]
EFNB1 Created Other Pages: Ephrin-B1 (No Data); EFNB1 (No Data); CFND (No Data); Cfnd (No Data); CFNS (No Data); Cfns (No Data); EFL3 (No Data); Efl3 (No Data); EPLG2 (No Data); Eplg2 (No Data); Elk-L (No Data); Elk-l (No Data); LERK2 (No Data); Lerk2 (No Data); MGC8782 (No Data); Mgc8782 (No Data); [15]
PABPC1 Created Other Pages: Poly binding protein (No Data); PABPC1 (No Data); PABP1 (No Data); Pabp1 (No Data); PAB1 (No Data); Pab1 (No Data); PABP (No Data); Pabp (No Data); PABPC2 (No Data); Pabpc2 (No Data); PABPL1 (No Data); Pabpl1 (No Data); [16]
ERCC1 Created Other Pages: Excision repair cross-complementing rodent repair deficiency (Redirect -> ERCC2 gene); ERCC1 (No Data); UV20 (No Data); Uv20 (No Data); ERCC2 gene (Codes Found, but no match[skip]); [17]
NPC1 Manual Inspection (Page not found) Other Pages: Niemann-Pick disease (Unknown Data); NPC1 (Protein Template); NPC (DisAmbig); Npc (Redirect -> Non-player character); Non-player character (Unknown Data); [18]
GYPA Manual Inspection (Page not found) Other Pages: Glycophorin A (No Data); GYPA (No Data); MN (DisAmbig); Mn (Redirect -> MN); MNS (DisAmbig); Mns (No Data); CD235a (No Data); Cd235a (No Data); GPA (Redirect -> Grade (education)); Gpa (No Data); GPErik (No Data); Gperik (No Data); GPSAT (No Data); Gpsat (No Data); GpMiIII (No Data); Gpmiiii (No Data); HGpMiIII (No Data); Hgpmiiii (No Data); HGpMiV (No Data); Hgpmiv (No Data); HGpMiX (No Data); Hgpmix (No Data); HGpMiXI (No Data); Hgpmixi (No Data); HGpSta(C) (No Data); Hgpsta(c) (No Data); Grade (education) (Unknown Data); [19]
NEUROD1 Created Other Pages: Neurogenic differentiation 1 (No Data); NEUROD1 (No Data); BETA2 (No Data); Beta2 (No Data); BHF-1 (No Data); Bhf-1 (No Data); NEUROD (No Data); Neurod (No Data); [20]
IL17A Manual Inspection (Page not found) Other Pages: Interleukin 17A (No Data); IL17A (No Data); CTLA8 (No Data); Ctla8 (No Data); IL-17 (No Data); Il-17 (Redirect -> interleukin 17); IL-17A (No Data); Il-17a (No Data); IL17 (No Data); Il17 (No Data); Interleukin 17 (Protein Template); [21]
EIF5A Created Other Pages: Eukaryotic translation initiation factor 5A (No Data); EIF5A (No Data); EIF-5A (No Data); Eif-5a (No Data); EIF5A1 (No Data); Eif5a1 (No Data); MGC104255 (No Data); Mgc104255 (No Data); MGC99547 (No Data); Mgc99547 (No Data); UORF (No Data); Uorf (No Data); UORF A (No Data); Uorf a (No Data); [22]
MAX Manual Inspection (Page not found) Other Pages: MYC associated factor X (No Data); MAX (DisAmbig); MGC10775 (No Data); Mgc10775 (No Data); MGC11225 (No Data); Mgc11225 (No Data); MGC18164 (No Data); Mgc18164 (No Data); MGC34679 (No Data); Mgc34679 (No Data); MGC36767 (No Data); Mgc36767 (No Data); Orf1 (No Data); [23]
APBB1 Manual Inspection (Page not found) Other Pages: Amyloid beta (Protein Template); APBB1 (No Data); FE65 (No Data); Fe65 (No Data); MGC:9072 (No Data); Mgc:9072 (No Data); RIR (DisAmbig); Rir (No Data); [24]
GPI Manual Inspection (Page not found) Other Pages: Glucose phosphate isomerase (Redirect -> Glucose isomerase); GPI (DisAmbig); PGI (DisAmbig); Pgi (No Data); AMF (DisAmbig); Amf (Redirect -> AMF); GNPI (No Data); Gnpi (No Data); NLK (No Data); Nlk (No Data); PHI (DisAmbig); Phi (DisAmbig); SA-36 (No Data); Sa-36 (No Data); Glucose isomerase (Unknown Data); [25]

Vebose Log - Date: 23:11, 8 November 2007 (UTC)[edit]

ACAN[edit]

  • INFO: Beginning work on ACAN... {November 8, 2007 1:18:03 PM PST}
  • UPLOAD: Added new Image to wiki: PBB Protein ACAN image.jpg {November 8, 2007 1:19:15 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:19:36 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_ACAN_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1tdq.
 | PDB = {{PDB2|1tdq}}
 | Name = Aggrecan
 | HGNCid = 319
 | Symbol = ACAN
 | AltSymbols =; AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK
 | OMIM = 155760
 | ECnumber =  
 | Homologene =  
 | MGIid =  
 | GeneAtlas_image1 = PBB_GE_ACAN_207692_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_ACAN_205679_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_ACAN_217161_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0005540 |text = hyaluronic acid binding}} {{GNF_GO|id=GO:0030021 |text = extracellular matrix structural constituent conferring compression resistance}} 
 | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005604 |text = basement membrane}} 
 | Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001502 |text = cartilage condensation}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0030166 |text = proteoglycan biosynthetic process}} {{GNF_GO|id=GO:0030199 |text = collagen fibril organization}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 176
    | Hs_Ensembl = ENSG00000157766
    | Hs_RefseqProtein = XP_001131727
    | Hs_RefseqmRNA = XM_001131727
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 87147709
    | Hs_GenLoc_end = 87218716
    | Hs_Uniprot = P16112
    | Mm_EntrezGene =  
    | Mm_Ensembl =  
    | Mm_RefseqmRNA =  
    | Mm_RefseqProtein =  
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Aggrecan''', also known as '''ACAN''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.<ref>{{cite web | title = Entrez Gene: ACAN aggrecan| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=176| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Watanabe H, Yamada Y, Kimata K |title=Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function. |journal=J. Biochem. |volume=124 |issue= 4 |pages= 687-93 |year= 1999 |pmid= 9756610 |doi=  }}
*{{cite journal  | author=Roughley P, Martens D, Rantakokko J, ''et al.'' |title=The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage. |journal=European cells & materials |volume=11 |issue=  |pages= 1-7; discussion 7 |year= 2006 |pmid= 16425147 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

AIRE[edit]

  • INFO: Beginning work on AIRE... {November 8, 2007 1:20:21 PM PST}
  • UPLOAD: Added new Image to wiki: PBB Protein AIRE image.jpg {November 8, 2007 2:37:18 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:37:36 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_AIRE_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xwh.
 | PDB = {{PDB2|1xwh}}
 | Name = Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
 | HGNCid = 360
 | Symbol = AIRE
 | AltSymbols =; AIRE1; APECED; APS1; APSI; PGA1
 | OMIM = 607358
 | ECnumber =  
 | Homologene = 327
 | MGIid = 1338803
 | GeneAtlas_image1 = PBB_GE_AIRE_208090_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0045182 |text = translation regulator activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006959 |text = humoral immune response}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 326
    | Hs_Ensembl = ENSG00000160224
    | Hs_RefseqProtein = NP_000374
    | Hs_RefseqmRNA = NM_000383
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 44530191
    | Hs_GenLoc_end = 44542486
    | Hs_Uniprot = O43918
    | Mm_EntrezGene = 11634
    | Mm_Ensembl = ENSMUSG00000000731
    | Mm_RefseqmRNA = NM_009646
    | Mm_RefseqProtein = NP_033776
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 77433160
    | Mm_GenLoc_end = 77446709
    | Mm_Uniprot = Q3ZB65
  }}
}}
'''Autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)''', also known as '''AIRE''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).<ref>{{cite web | title = Entrez Gene: AIRE autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=326| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Björses P, Aaltonen J, Horelli-Kuitunen N, ''et al.'' |title=Gene defect behind APECED: a new clue to autoimmunity. |journal=Hum. Mol. Genet. |volume=7 |issue= 10 |pages= 1547-53 |year= 1998 |pmid= 9735375 |doi=  }}
*{{cite journal  | author=Heino M, Peterson P, Kudoh J, ''et al.'' |title=APECED mutations in the autoimmune regulator (AIRE) gene. |journal=Hum. Mutat. |volume=18 |issue= 3 |pages= 205-11 |year= 2001 |pmid= 11524731 |doi= 10.1002/humu.1176 }}
*{{cite journal  | author=Sato K, Nakajima K, Imamura H, ''et al.'' |title=A novel missense mutation of AIRE gene in a patient with autoimmune polyendocrinopathy, candidiasis and ectodermal dystrophy (APECED), accompanied with progressive muscular atrophy: case report and review of the literature in Japan. |journal=Endocr. J. |volume=49 |issue= 6 |pages= 625-33 |year= 2003 |pmid= 12625412 |doi=  }}
*{{cite journal  | author=Ruan QG, She JX |title=Autoimmune polyglandular syndrome type 1 and the autoimmune regulator. |journal=Clin. Lab. Med. |volume=24 |issue= 1 |pages= 305-17 |year= 2004 |pmid= 15157567 |doi= 10.1016/j.cll.2004.01.008 }}
*{{cite journal  | author=Holmdahl R |title=Aire-ing self antigen variability and tolerance. |journal=Eur. J. Immunol. |volume=37 |issue= 3 |pages= 598-601 |year= 2007 |pmid= 17323409 |doi= 10.1002/eji.200737152 }}
}}
{{refend}}

{{protein-stub}}
 

APBB1[edit]

  • INFO: Beginning work on APBB1... {November 8, 2007 1:19:36 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein APBB1 image.jpg {November 8, 2007 1:20:07 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:20:21 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_APBB1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2e45.
 | PDB = {{PDB2|2e45}}
 | Name = Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
 | HGNCid = 581
 | Symbol = APBB1
 | AltSymbols =; FE65; MGC:9072; RIR
 | OMIM = 602709
 | ECnumber =  
 | Homologene = 898
 | MGIid = 107765
 | GeneAtlas_image1 = PBB_GE_APBB1_202652_at_tn.png
 | Function = {{GNF_GO|id=GO:0001540 |text = beta-amyloid binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0035035 |text = histone acetyltransferase binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}} {{GNF_GO|id=GO:0030426 |text = growth cone}} {{GNF_GO|id=GO:0045202 |text = synapse}} 
 | Process = {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0030048 |text = actin filament-based movement}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045749 |text = negative regulation of S phase of mitotic cell cycle}} {{GNF_GO|id=GO:0050760 |text = negative regulation of thymidylate synthase biosynthetic process}} {{GNF_GO|id=GO:0050821 |text = protein stabilization}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 322
    | Hs_Ensembl = ENSG00000166313
    | Hs_RefseqProtein = NP_001155
    | Hs_RefseqmRNA = NM_001164
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 6372964
    | Hs_GenLoc_end = 6389153
    | Hs_Uniprot = O00213
    | Mm_EntrezGene = 11785
    | Mm_Ensembl = ENSMUSG00000037032
    | Mm_RefseqmRNA = NM_009685
    | Mm_RefseqProtein = NP_033815
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 105432305
    | Mm_GenLoc_end = 105442536
    | Mm_Uniprot = Q80Y77
  }}
}}
'''Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)''', also known as '''APBB1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known.<ref>{{cite web | title = Entrez Gene: APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=322| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Russo T, Faraonio R, Minopoli G, ''et al.'' |title=Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein. |journal=FEBS Lett. |volume=434 |issue= 1-2 |pages= 1-7 |year= 1998 |pmid= 9738440 |doi=  }}
*{{cite journal  | author=Askanas V, Engel WK |title=Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-beta, misfolded proteins, predisposing genes, and aging. |journal=Current opinion in rheumatology |volume=15 |issue= 6 |pages= 737-44 |year= 2004 |pmid= 14569203 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

EFNB1[edit]

  • INFO: Beginning work on EFNB1... {November 8, 2007 2:37:36 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 2:38:23 PM PST}
  • CREATED: Created new protein page: EFNB1 {November 8, 2007 2:38:30 PM PST}

EIF5A[edit]

  • INFO: Beginning work on EIF5A... {November 8, 2007 2:38:30 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 2:39:47 PM PST}
  • CREATED: Created new protein page: EIF5A {November 8, 2007 2:39:54 PM PST}

ERCC1[edit]

  • INFO: Beginning work on ERCC1... {November 8, 2007 2:39:54 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein ERCC1 image.jpg {November 8, 2007 2:40:46 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 2:40:57 PM PST}
  • CREATED: Created new protein page: ERCC1 {November 8, 2007 2:41:07 PM PST}

FLI1[edit]

  • INFO: Beginning work on FLI1... {November 8, 2007 2:41:07 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein FLI1 image.jpg {November 8, 2007 2:42:20 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 2:42:32 PM PST}
  • CREATED: Created new protein page: FLI1 {November 8, 2007 2:42:40 PM PST}

FOLH1[edit]

  • INFO: Beginning work on FOLH1... {November 8, 2007 2:42:40 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein FOLH1 image.jpg {November 8, 2007 2:44:21 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:44:51 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_FOLH1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1z8l.
 | PDB = {{PDB2|1z8l}}, {{PDB2|2c6c}}, {{PDB2|2c6g}}, {{PDB2|2c6p}}, {{PDB2|2cij}}, {{PDB2|2jbj}}, {{PDB2|2jbk}}, {{PDB2|2oot}}, {{PDB2|2pvv}}, {{PDB2|2pvw}}
 | Name = Folate hydrolase (prostate-specific membrane antigen) 1
 | HGNCid = 3788
 | Symbol = FOLH1
 | AltSymbols =; PSM; FGCP; FOLH; GCP2; GCPII; NAALAD1; NAALAdase; PSMA; mGCP
 | OMIM = 600934
 | ECnumber =  
 | Homologene = 71658
 | MGIid =  
 | GeneAtlas_image1 = PBB_GE_FOLH1_205860_x_at_tn.png
 | GeneAtlas_image2 = PBB_GE_FOLH1_211303_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_FOLH1_215363_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0004180 |text = carboxypeptidase activity}} {{GNF_GO|id=GO:0008237 |text = metallopeptidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016805 |text = dipeptidase activity}} {{GNF_GO|id=GO:0043275 |text = glutamate carboxypeptidase II activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2346
    | Hs_Ensembl = ENSG00000086205
    | Hs_RefseqProtein = NP_001014986
    | Hs_RefseqmRNA = NM_001014986
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 49124766
    | Hs_GenLoc_end = 49186798
    | Hs_Uniprot = Q04609
    | Mm_EntrezGene =  
    | Mm_Ensembl =  
    | Mm_RefseqmRNA =  
    | Mm_RefseqProtein =  
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Folate hydrolase (prostate-specific membrane antigen) 1''', also known as '''FOLH1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.<ref>{{cite web | title = Entrez Gene: FOLH1 folate hydrolase (prostate-specific membrane antigen) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2346| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Bander NH, Nanus DM, Milowsky MI, ''et al.'' |title=Targeted systemic therapy of prostate cancer with a monoclonal antibody to prostate-specific membrane antigen. |journal=Semin. Oncol. |volume=30 |issue= 5 |pages= 667-76 |year= 2003 |pmid= 14571414 |doi=  }}
*{{cite journal  | author=Rajasekaran AK, Anilkumar G, Christiansen JJ |title=Is prostate-specific membrane antigen a multifunctional protein? |journal=Am. J. Physiol., Cell Physiol. |volume=288 |issue= 5 |pages= C975-81 |year= 2005 |pmid= 15840561 |doi= 10.1152/ajpcell.00506.2004 }}
}}
{{refend}}

{{protein-stub}}
 

GPI[edit]

  • INFO: Beginning work on GPI... {November 8, 2007 2:44:51 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein GPI image.jpg {November 8, 2007 2:45:24 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:45:45 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_GPI_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dqr.
 | PDB = {{PDB2|1dqr}}, {{PDB2|1g98}}, {{PDB2|1gzd}}, {{PDB2|1gzv}}, {{PDB2|1hm5}}, {{PDB2|1hox}}, {{PDB2|1iat}}, {{PDB2|1iri}}, {{PDB2|1jiq}}, {{PDB2|1jlh}}, {{PDB2|1koj}}, {{PDB2|1n8t}}, {{PDB2|1nuh}}, {{PDB2|1xtb}}
 | Name = Glucose phosphate isomerase
 | HGNCid = 4458
 | Symbol = GPI
 | AltSymbols =; PGI; AMF; GNPI; NLK; PHI; SA-36
 | OMIM = 172400
 | ECnumber =  
 | Homologene = 145
 | MGIid = 95797
 | GeneAtlas_image1 = PBB_GE_GPI_208308_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004347 |text = glucose-6-phosphate isomerase activity}} {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}} 
 | Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} 
 | Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006094 |text = gluconeogenesis}} {{GNF_GO|id=GO:0006096 |text = glycolysis}} {{GNF_GO|id=GO:0006959 |text = humoral immune response}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007599 |text = hemostasis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2821
    | Hs_Ensembl = ENSG00000105220
    | Hs_RefseqProtein = NP_000166
    | Hs_RefseqmRNA = NM_000175
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 39547727
    | Hs_GenLoc_end = 39583072
    | Hs_Uniprot = P06744
    | Mm_EntrezGene = 14751
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = XM_001004276
    | Mm_RefseqProtein = XP_001004276
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Glucose phosphate isomerase''', also known as '''GPI''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.<ref>{{cite web | title = Entrez Gene: GPI glucose phosphate isomerase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2821| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Kugler W, Lakomek M |title=Glucose-6-phosphate isomerase deficiency. |journal=Baillieres Best Pract. Res. Clin. Haematol. |volume=13 |issue= 1 |pages= 89-101 |year= 2000 |pmid= 10916680 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

GRIA1[edit]

  • INFO: Beginning work on GRIA1... {November 8, 2007 2:45:45 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:46:08 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Glutamate receptor, ionotropic, AMPA 1
 | HGNCid = 4571
 | Symbol = GRIA1
 | AltSymbols =; GLUH1; GLUR1; GLURA; HBGR1; MGC133252
 | OMIM = 138248
 | ECnumber =  
 | Homologene = 20226
 | MGIid = 95808
 | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004971 |text = alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005234 |text = extracellular-glutamate-gated ion channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015277 |text = kainate selective glutamate receptor activity}} 
 | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0014069 |text = postsynaptic density}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}} 
 | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007616 |text = long-term memory}} {{GNF_GO|id=GO:0031623 |text = receptor internalization}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2890
    | Hs_Ensembl = ENSG00000155511
    | Hs_RefseqProtein = NP_000818
    | Hs_RefseqmRNA = NM_000827
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 152850499
    | Hs_GenLoc_end = 153171354
    | Hs_Uniprot = P42261
    | Mm_EntrezGene = 14799
    | Mm_Ensembl = ENSMUSG00000020524
    | Mm_RefseqmRNA = NM_008165
    | Mm_RefseqProtein = NP_032191
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 57017321
    | Mm_GenLoc_end = 57143990
    | Mm_Uniprot = Q5NBY0
  }}
}}
'''Glutamate receptor, ionotropic, AMPA 1''', also known as '''GRIA1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.<ref>{{cite web | title = Entrez Gene: GRIA1 glutamate receptor, ionotropic, AMPA 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2890| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

GTF2I[edit]

  • INFO: Beginning work on GTF2I... {November 8, 2007 2:46:08 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein GTF2I image.jpg {November 8, 2007 2:46:21 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:46:53 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_GTF2I_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1q60.
 | PDB = {{PDB2|1q60}}, {{PDB2|2d9b}}, {{PDB2|2dn4}}
 | Name = General transcription factor II, i
 | HGNCid = 4659
 | Symbol = GTF2I
 | AltSymbols =; WBS; BAP-135; BAP135; BTKAP1; DIWS; IB291; SPIN; TFII-I; WBSCR6
 | OMIM = 601679
 | ECnumber =  
 | Homologene = 7748
 | MGIid = 1202722
 | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016251 |text = general RNA polymerase II transcription factor activity}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2969
    | Hs_Ensembl =  
    | Hs_RefseqProtein = XP_001130609
    | Hs_RefseqmRNA = XM_001130609
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 14886
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = XM_903569
    | Mm_RefseqProtein = XP_908662
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''General transcription factor II, i''', also known as '''GTF2I''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. The exon(s) encoding 5' UTR has not been fully defined, but this gene is known to contain at least 34 exons, and its alternative splicing generates 4 transcript variants.<ref>{{cite web | title = Entrez Gene: GTF2I general transcription factor II, i| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2969| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

GYPA[edit]

  • INFO: Beginning work on GYPA... {November 8, 2007 2:46:53 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein GYPA image.jpg {November 8, 2007 2:48:22 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:48:56 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_GYPA_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1afo.
 | PDB = {{PDB2|1afo}}
 | Name = Glycophorin A (MNS blood group)
 | HGNCid = 4702
 | Symbol = GYPA
 | AltSymbols =; MN; MNS; CD235a; GPA; GPErik; GPSAT; GpMiIII; HGpMiIII; HGpMiV; HGpMiX; HGpMiXI; HGpSta(C)
 | OMIM = 111300
 | ECnumber =  
 | Homologene = 48076
 | MGIid =  
 | GeneAtlas_image1 = PBB_GE_GYPA_205837_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_GYPA_205838_at_tn.png
 | GeneAtlas_image3 = PBB_GE_GYPA_211820_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} 
 | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0008150 |text = biological_process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2993
    | Hs_Ensembl = ENSG00000170180
    | Hs_RefseqProtein = NP_002090
    | Hs_RefseqmRNA = NM_002099
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 145249906
    | Hs_GenLoc_end = 145281294
    | Hs_Uniprot = P02724
    | Mm_EntrezGene =  
    | Mm_Ensembl =  
    | Mm_RefseqmRNA =  
    | Mm_RefseqProtein =  
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Glycophorin A (MNS blood group)''', also known as '''GYPA''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPA gene consists of 7 exons and has 97% sequence homology with GYPB from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.<ref>{{cite web | title = Entrez Gene: GYPA glycophorin A (MNS blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2993| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Blumenfeld OO, Huang CH |title=Molecular genetics of the glycophorin gene family, the antigens for MNSs blood groups: multiple gene rearrangements and modulation of splice site usage result in extensive diversification. |journal=Hum. Mutat. |volume=6 |issue= 3 |pages= 199-209 |year= 1996 |pmid= 8535438 |doi= 10.1002/humu.1380060302 }}
*{{cite journal  | author=Blumenfeld OO, Huang CH |title=Molecular genetics of glycophorin MNS variants. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=4 |issue= 4 |pages= 357-65 |year= 1997 |pmid= 9269716 |doi=  }}
*{{cite journal  | author=Johnson ST, McFarland JG, Kelly KJ, ''et al.'' |title=Transfusion support with RBCs from an Mk homozygote in a case of autoimmune hemolytic anemia following diphtheria-pertussis-tetanus vaccination. |journal=Transfusion |volume=42 |issue= 5 |pages= 567-71 |year= 2002 |pmid= 12084164 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

IL17A[edit]

  • INFO: Beginning work on IL17A... {November 8, 2007 2:48:56 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:49:51 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Interleukin 17A
 | HGNCid = 5981
 | Symbol = IL17A
 | AltSymbols =; CTLA8; IL-17; IL-17A; IL17
 | OMIM = 603149
 | ECnumber =  
 | Homologene = 1651
 | MGIid = 107364
 | GeneAtlas_image1 = PBB_GE_IL17A_208402_at_tn.png
 | GeneAtlas_image2 = PBB_GE_IL17A_216876_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} 
 | Process = {{GNF_GO|id=GO:0006486 |text = protein amino acid glycosylation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008219 |text = cell death}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3605
    | Hs_Ensembl = ENSG00000112115
    | Hs_RefseqProtein = NP_002181
    | Hs_RefseqmRNA = NM_002190
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 52159144
    | Hs_GenLoc_end = 52163395
    | Hs_Uniprot = Q16552
    | Mm_EntrezGene = 16171
    | Mm_Ensembl = ENSMUSG00000025929
    | Mm_RefseqmRNA = NM_010552
    | Mm_RefseqProtein = NP_034682
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 20716056
    | Mm_GenLoc_end = 20719647
    | Mm_Uniprot = Q544E6
  }}
}}
'''Interleukin 17A''', also known as '''IL17A''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.<ref>{{cite web | title = Entrez Gene: IL17A interleukin 17A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3605| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Gaffen SL |title=Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis. |journal=Arthritis Res. Ther. |volume=6 |issue= 6 |pages= 240-7 |year= 2005 |pmid= 15535837 |doi= 10.1186/ar1444 }}
*{{cite journal  | author=Lubberts E, Koenders MI, van den Berg WB |title=The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. |journal=Arthritis Res. Ther. |volume=7 |issue= 1 |pages= 29-37 |year= 2006 |pmid= 15642151 |doi= 10.1186/ar1478 }}
}}
{{refend}}

{{protein-stub}}
 

ING1[edit]

  • INFO: Beginning work on ING1... {November 8, 2007 2:49:51 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:51:18 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Inhibitor of growth family, member 1
 | HGNCid = 6062
 | Symbol = ING1
 | AltSymbols =; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a
 | OMIM = 601566
 | ECnumber =  
 | Homologene = 40119
 | MGIid = 1349481
 | GeneAtlas_image1 = PBB_GE_ING1_209808_x_at_tn.png
 | GeneAtlas_image2 = PBB_GE_ING1_208415_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_ING1_210350_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3621
    | Hs_Ensembl = ENSG00000153487
    | Hs_RefseqProtein = NP_005528
    | Hs_RefseqmRNA = NM_005537
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 110163084
    | Hs_GenLoc_end = 110171422
    | Hs_Uniprot = Q9UK53
    | Mm_EntrezGene = 26356
    | Mm_Ensembl = ENSMUSG00000045969
    | Mm_RefseqmRNA = XM_976418
    | Mm_RefseqProtein = XP_981512
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 11556038
    | Mm_GenLoc_end = 11563222
    | Mm_Uniprot = Q3ULE3
  }}
}}
'''Inhibitor of growth family, member 1''', also known as '''ING1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: ING1 inhibitor of growth family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3621| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Campos EI, Chin MY, Kuo WH, Li G |title=Biological functions of the ING family tumor suppressors. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 19-20 |pages= 2597-613 |year= 2004 |pmid= 15526165 |doi= 10.1007/s00018-004-4199-4 }}
}}
{{refend}}

{{protein-stub}}
 

KPNA5[edit]

  • INFO: Beginning work on KPNA5... {November 8, 2007 2:51:18 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 2:52:01 PM PST}
  • CREATED: Created new protein page: KPNA5 {November 8, 2007 2:52:10 PM PST}

MAP2K6[edit]

  • INFO: Beginning work on MAP2K6... {November 8, 2007 2:58:42 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 2:59:43 PM PST}
  • CREATED: Created new protein page: MAP2K6 {November 8, 2007 2:59:50 PM PST}

MAX[edit]

  • INFO: Beginning work on MAX... {November 8, 2007 2:52:10 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein MAX image.jpg {November 8, 2007 2:54:14 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:54:33 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_MAX_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1an2.
 | PDB = {{PDB2|1an2}}, {{PDB2|1hlo}}, {{PDB2|1nkp}}, {{PDB2|1nlw}}, {{PDB2|1r05}}
 | Name = MYC associated factor X
 | HGNCid = 6913
 | Symbol = MAX
 | AltSymbols =; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; orf1
 | OMIM = 154950
 | ECnumber =  
 | Homologene = 1786
 | MGIid = 96921
 | GeneAtlas_image1 = PBB_GE_MAX_214108_at_tn.png
 | GeneAtlas_image2 = PBB_GE_MAX_208403_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_MAX_209331_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4149
    | Hs_Ensembl = ENSG00000125952
    | Hs_RefseqProtein = NP_002373
    | Hs_RefseqmRNA = NM_002382
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 64542645
    | Hs_GenLoc_end = 64638980
    | Hs_Uniprot = P61244
    | Mm_EntrezGene = 17187
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = XM_001002021
    | Mm_RefseqProtein = XP_001002021
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''MYC associated factor X''', also known as '''MAX''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature for some of them is unknown.<ref>{{cite web | title = Entrez Gene: MAX MYC associated factor X| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4149| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Grandori C, Cowley SM, James LP, Eisenman RN |title=The Myc/Max/Mad network and the transcriptional control of cell behavior. |journal=Annu. Rev. Cell Dev. Biol. |volume=16 |issue=  |pages= 653-99 |year= 2001 |pmid= 11031250 |doi= 10.1146/annurev.cellbio.16.1.653 }}
*{{cite journal  | author=Lüscher B |title=Function and regulation of the transcription factors of the Myc/Max/Mad network. |journal=Gene |volume=277 |issue= 1-2 |pages= 1-14 |year= 2001 |pmid= 11602341 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

NEUROD1[edit]

  • INFO: Beginning work on NEUROD1... {November 8, 2007 2:54:33 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 2:55:12 PM PST}
  • CREATED: Created new protein page: NEUROD1 {November 8, 2007 2:55:19 PM PST}

NPC1[edit]

  • INFO: Beginning work on NPC1... {November 8, 2007 2:55:19 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:55:54 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Niemann-Pick disease, type C1
 | HGNCid = 7897
 | Symbol = NPC1
 | AltSymbols =; NPC
 | OMIM = 607623
 | ECnumber =  
 | Homologene = 228
 | MGIid = 1097712
 | GeneAtlas_image1 = PBB_GE_NPC1_202679_at_tn.png
 | Function = {{GNF_GO|id=GO:0005478 |text = transporter activity}} {{GNF_GO|id=GO:0008158 |text = hedgehog receptor activity}} {{GNF_GO|id=GO:0015248 |text = sterol transporter activity}} 
 | Component = {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0007041 |text = lysosomal transport}} {{GNF_GO|id=GO:0008206 |text = bile acid metabolic process}} {{GNF_GO|id=GO:0030301 |text = cholesterol transport}} {{GNF_GO|id=GO:0042632 |text = cholesterol homeostasis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4864
    | Hs_Ensembl = ENSG00000141458
    | Hs_RefseqProtein = NP_000262
    | Hs_RefseqmRNA = NM_000271
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 19365463
    | Hs_GenLoc_end = 19420426
    | Hs_Uniprot = O15118
    | Mm_EntrezGene = 18145
    | Mm_Ensembl = ENSMUSG00000024413
    | Mm_RefseqmRNA = NM_008720
    | Mm_RefseqProtein = NP_032746
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 12333387
    | Mm_GenLoc_end = 12379894
    | Mm_Uniprot = Q3U2B2
  }}
}}
'''Niemann-Pick disease, type C1''', also known as '''NPC1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = NPC1 was identified as the gene that when mutated, results in Niemann-Pick C disease. NPC1 encodes a putative integral membrane protein containing motifs consistent with a role in intracellular transport of cholesterol to post-lysosomal destinations.<ref>{{cite web | title = Entrez Gene: NPC1 Niemann-Pick disease, type C1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4864| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Vanier MT, Suzuki K |title=Recent advances in elucidating Niemann-Pick C disease. |journal=Brain Pathol. |volume=8 |issue= 1 |pages= 163-74 |year= 1998 |pmid= 9458174 |doi=  }}
*{{cite journal  | author=Liscum L, Klansek JJ |title=Niemann-Pick disease type C. |journal=Curr. Opin. Lipidol. |volume=9 |issue= 2 |pages= 131-5 |year= 1998 |pmid= 9559270 |doi=  }}
*{{cite journal  | author=Morris JA, Carstea ED |title=Niemann-Pick C disease: cholesterol handling gone awry. |journal=Molecular medicine today |volume=4 |issue= 12 |pages= 525-31 |year= 1999 |pmid= 9866822 |doi=  }}
*{{cite journal  | author=Garver WS, Heidenreich RA |title=The Niemann-Pick C proteins and trafficking of cholesterol through the late endosomal/lysosomal system. |journal=Curr. Mol. Med. |volume=2 |issue= 5 |pages= 485-505 |year= 2003 |pmid= 12125814 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

PABPC1[edit]

  • INFO: Beginning work on PABPC1... {November 8, 2007 3:01:28 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein PABPC1 image.jpg {November 8, 2007 3:01:43 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 3:02:03 PM PST}
  • CREATED: Created new protein page: PABPC1 {November 8, 2007 3:02:10 PM PST}

PRG2[edit]

  • INFO: Beginning work on PRG2... {November 8, 2007 2:56:46 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein PRG2 image.jpg {November 8, 2007 2:57:18 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:57:32 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PRG2_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h8u.
 | PDB = {{PDB2|1h8u}}, {{PDB2|2brs}}
 | Name = Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
 | HGNCid = 9362
 | Symbol = PRG2
 | AltSymbols =; MBP; BMPG; MGC14537
 | OMIM = 605601
 | ECnumber =  
 | Homologene = 2044
 | MGIid = 103294
 | GeneAtlas_image1 = PBB_GE_PRG2_211743_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0008201 |text = heparin binding}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5553
    | Hs_Ensembl = ENSG00000186652
    | Hs_RefseqProtein = NP_002719
    | Hs_RefseqmRNA = NM_002728
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 56910832
    | Hs_GenLoc_end = 56914684
    | Hs_Uniprot = P13727
    | Mm_EntrezGene = 19074
    | Mm_Ensembl = ENSMUSG00000027073
    | Mm_RefseqmRNA = NM_008920
    | Mm_RefseqProtein = NP_032946
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 84781300
    | Mm_GenLoc_end = 84784471
    | Mm_Uniprot = Q545D8
  }}
}}
'''Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)''', also known as '''PRG2''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases.<ref>{{cite web | title = Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5553| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Vanhaesebroeck B, Alessi DR |title=The PI3K-PDK1 connection: more than just a road to PKB. |journal=Biochem. J. |volume=346 Pt 3 |issue=  |pages= 561-76 |year= 2000 |pmid= 10698680 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

PRKCH[edit]

  • INFO: Beginning work on PRKCH... {November 8, 2007 2:57:32 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein PRKCH image.jpg {November 8, 2007 2:58:21 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:58:42 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PRKCH_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fk9.
 | PDB = {{PDB2|2fk9}}
 | Name = Protein kinase C, eta
 | HGNCid = 9403
 | Symbol = PRKCH
 | AltSymbols =; MGC26269; MGC5363; PKC-L; PKCL; PRKCL; nPKC-eta
 | OMIM = 605437
 | ECnumber =  
 | Homologene = 84384
 | MGIid = 97600
 | GeneAtlas_image1 = PBB_GE_PRKCH_206099_at_tn.png
 | GeneAtlas_image2 = PBB_GE_PRKCH_218764_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004697 |text = protein kinase C activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = 
 | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5583
    | Hs_Ensembl = ENSG00000027075
    | Hs_RefseqProtein = NP_006246
    | Hs_RefseqmRNA = NM_006255
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 60858186
    | Hs_GenLoc_end = 61087443
    | Hs_Uniprot = P24723
    | Mm_EntrezGene = 18755
    | Mm_Ensembl = ENSMUSG00000021108
    | Mm_RefseqmRNA = NM_008856
    | Mm_RefseqProtein = NP_032882
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 74503879
    | Mm_GenLoc_end = 74697023
    | Mm_Uniprot = Q3U1I0
  }}
}}
'''Protein kinase C, eta''', also known as '''PRKCH''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.<ref>{{cite web | title = Entrez Gene: PRKCH protein kinase C, eta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5583| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

PSMA1[edit]

  • INFO: Beginning work on PSMA1... {November 8, 2007 2:59:50 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein PSMA1 image.jpg {November 8, 2007 3:01:02 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 3:01:28 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PSMA1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1iru.
 | PDB = {{PDB2|1iru}}
 | Name = Proteasome (prosome, macropain) subunit, alpha type, 1
 | HGNCid = 9530
 | Symbol = PSMA1
 | AltSymbols =; HC2; MGC14542; MGC14575; MGC14751; MGC1667; MGC21459; MGC22853; MGC23915; NU; PROS30
 | OMIM = 602854
 | ECnumber =  
 | Homologene = 2080
 | MGIid = 1347005
 | GeneAtlas_image1 = PBB_GE_PSMA1_210759_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_PSMA1_201676_x_at_tn.png
 | GeneAtlas_image3 = PBB_GE_PSMA1_211746_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004298 |text = threonine endopeptidase activity}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005839 |text = proteasome core complex (sensu Eukaryota)}} {{GNF_GO|id=GO:0005844 |text = polysome}} 
 | Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5682
    | Hs_Ensembl = ENSG00000129084
    | Hs_RefseqProtein = NP_002777
    | Hs_RefseqmRNA = NM_002786
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 14482999
    | Hs_GenLoc_end = 14621739
    | Hs_Uniprot = P25786
    | Mm_EntrezGene = 26440
    | Mm_Ensembl = ENSMUSG00000030751
    | Mm_RefseqmRNA = NM_011965
    | Mm_RefseqProtein = NP_036095
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 114056081
    | Mm_GenLoc_end = 114065641
    | Mm_Uniprot = Q3TS44
  }}
}}
'''Proteasome (prosome, macropain) subunit, alpha type, 1''', also known as '''PSMA1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5682| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue=  |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal  | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

RACGAP1[edit]

  • INFO: Beginning work on RACGAP1... {November 8, 2007 3:02:10 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein RACGAP1 image.jpg {November 8, 2007 3:02:27 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 3:02:40 PM PST}
  • CREATED: Created new protein page: RACGAP1 {November 8, 2007 3:02:47 PM PST}

SERPINB2[edit]

  • INFO: Beginning work on SERPINB2... {November 8, 2007 2:55:54 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein SERPINB2 image.jpg {November 8, 2007 2:56:25 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 2:56:46 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_SERPINB2_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1by7.
 | PDB = {{PDB2|1by7}}, {{PDB2|1jrr}}, {{PDB2|2arq}}, {{PDB2|2arr}}
 | Name = Serpin peptidase inhibitor, clade B (ovalbumin), member 2
 | HGNCid = 8584
 | Symbol = SERPINB2
 | AltSymbols =; PAI; HsT1201; PAI-2; PAI2; PLANH2
 | OMIM = 173390
 | ECnumber =  
 | Homologene = 20571
 | MGIid = 97609
 | GeneAtlas_image1 = PBB_GE_SERPINB2_204614_at_tn.png
 | Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0008243 |text = plasminogen activator activity}} 
 | Component = 
 | Process = {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5055
    | Hs_Ensembl = ENSG00000197632
    | Hs_RefseqProtein = NP_002566
    | Hs_RefseqmRNA = NM_002575
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 59705922
    | Hs_GenLoc_end = 59722100
    | Hs_Uniprot = P05120
    | Mm_EntrezGene = 18788
    | Mm_Ensembl = ENSMUSG00000062345
    | Mm_RefseqmRNA = NM_011111
    | Mm_RefseqProtein = NP_035241
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 109338970
    | Mm_GenLoc_end = 109353139
    | Mm_Uniprot = Q542A3
  }}
}}
'''Serpin peptidase inhibitor, clade B (ovalbumin), member 2''', also known as '''SERPINB2''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

end log.