User:Quasihuman/Animal models of epilepsy

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Animal models of epilepsy have helped to advance the understanding of how brains develop epilepsy (Epileptogenesis), and have been used in pre-clinical trials of antiepileptic drugs.[1] Epilepsy is a set of syndromes which have in common a predisposition to epileptic seizures.[2] Animal models of epilepsy and seizures can be divided into three basic categories: genetic animal models, chemically induced models, and electrically induced models.[3]

Genetic models[edit]

Chemically induced models[edit]

Electrically induced models[edit]


  1. ^ Sarkisian, Matthew R. (31 May 2001). "Overview of the Current Animal Models for Human Seizure and Epileptic Disorders". Epilepsy & Behavior. 2 (3): 201–216. doi:10.1006/ebeh.2001.0193. 
  2. ^ Chang, Bernard S. (25 September 2003). "Epilepsy". New England Journal of Medicine. 349 (13): 1257–1266. doi:10.1056/NEJMra022308.  Unknown parameter |coauthors= ignored (|author= suggested) (help)
  3. ^ Löscher, Wolfgang (31 May 2011). "Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs". Seizure. 20 (5): 359–368. PMID 21292505. doi:10.1016/j.seizure.2011.01.003. Retrieved 1 August 2012.