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Model organisms[edit]

Model organisms have been used in the study of INPP1 function. A conditional knockout mouse line, called Inpp1tm1a(KOMP)Wtsi[5][6] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[7][8][9]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[3][10] Twenty four tests were carried out on mutant mice and one significant abnormality was observed: a decreased susceptibility to bacterial infection.[3]


  1. ^ "Salmonella infection data for Inpp1". Wellcome Trust Sanger Institute. 
  2. ^ "Citrobacter infection data for Inpp1". Wellcome Trust Sanger Institute. 
  3. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  4. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  5. ^ "International Knockout Mouse Consortium". 
  6. ^ "Mouse Genome Informatics". 
  7. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. PMC 3572410Freely accessible. PMID 21677750. doi:10.1038/nature10163. 
  8. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474: 262-263. doi:10.1038/474262a. 
  9. ^ Collins FS, Rossant J, Wurst W (January 2007). A mouse for all reasons. Cell 128(1): 9-13. doi:10.1016/j.cell.2006.12.018 PMID 17218247. 
  10. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol. 12 (6): 224. PMID 21722353. doi:10.1186/gb-2011-12-6-224.