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Samudrala, Ram
Nationality USA
Fields Computational biology
Institutions University of Washington
Alma mater Ohio Wesleyan University, Center for Advanced Research in Biotechnology, Stanford University
Notable awards Searle Scholar TR100, NSF CAREER Award

Ram Samudrala is a computational biologist, holding a tenured faculty position at the University of Washington in Seattle, USA [1]. His work researches protein and proteome structure, function, interaction, design, and evolution spanning atomic to organismal levels of description. As of 2010, he has published nearly 90 manuscripts in this area[2] with a h-index of 25[3].

Samudrala is also a musician who has published and recorded work under the pseudonym TWISTED HELICES. He is the author of the Free Music Philosophy[4], first published in 1994, which predicted how the ease of copying and transmitting digital information by the Internet would lead to unprecedented violations of copyright laws, leading to new models of music (and other digital media) distribution.


Prior to joining the University of Washington in 2001, Samudrala was a post-doctoral fellow at Stanford University from 1997-2000, with a fellowship from the Program in Mathematics and Molecular Biology (funded by the NSF and the Burroughs Wellcome Fund). He received his undergraduate degrees in Computing Science and Genetics at Ohio Wesleyan University in 1993 and went on to complete his Ph.D. in Computational Structural Biology at the Center for Advanced Research in Biotechnology in Rockville, MD, in 1997.

Awards and Honours[edit]

Samudrala received a Searle Scholar Award in 2002, was named one of the world's top young innovators by MIT Technology Review in 2003, and was selected to present the University of Washington New Investigator Science in Medicine Lecture in 2004. In 2005, he received an NSF CAREER Award which recognizes outstanding scientists and engineers who show exceptional potential for leadership at the frontiers of knowledge. He was an NIH Director's Pioneer Award Finalist in 2006 (25/465 applicants selected as finalists). In 2008, he won the Alberta Heritage Foundation for Medical Research Visiting Scientist Award. That same year, he was awarded honorary diplomas from the cities of Carsma and Yaoton, Peru, for his work on vaccine discovery.


Samudrala's research has focussed on understanding how the genome of an organism specifies its behaviour and characteristics, and how that information may be used to improve quality of life. Specifically, he was the first to develop and apply an all heavy atom knowledge-based conditional probability discriminatory function for protein structure prediction in blind protein structure prediction experiments [5]. He has consistently taken part in, spoken at, and published in the proceedings of these experiments, known as CASP since its inception in 1994. His performances at CASP2 in 1996[6] and CASP3[7] in 1998 highlight some of the first improvements of blinded protein structure prediction.

External Links[edit]

Samudrala Computational Biology Group web site
Ram Samudrala's personal web site
Nutritious Rice for the World web site
Protinfo web server
Bioverse web server


  1. ^ Ram Samudrala's personal web site
  2. ^ Ram Samudrala's curriculum vitae
  3. ^ h-index based on Google Scholar
  4. ^ Free Music Philosophy
  5. ^ Samudrala R, Moult J. An all-atom distance-dependent conditional probability discriminatory function for protein structure prediction. Journal of Molecular Biology 275: 893-914, 1998
  6. ^ Samudrala R, Moult J. Handling context-sensitivity in protein structures using graph theory: bona fide prediction. Proteins: Structure, Function, and Genetics 29S: 43-49, 1997.
  7. ^ Samudrala R, Xia Y, Levitt M. Huang ES. Ab initio prediction of protein structure using a combined hierarchical approach. Proteins: Structure, Function, and Genetics S3: 194-198, 1999.