Vilayanur S. Ramachandran

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Vilayanur S. Ramachandran
Vilayanur S Ramachandran 2011 Shankbone.JPG
Ramachandran at the 2011 Time 100 gala
Born (1951-08-10) August 10, 1951 (age 66)
Tamil Nadu, India
Residence San Diego, California
Alma mater
Known for Research in neurology, visual perception, phantom limbs, synesthesia, autism, body integrity identity disorder
Awards Ariens-Kappers medal (1999), Padma Bhushan (2007), Honorary Fellow, Royal College of Physicians (2014)
Scientific career
Fields
Institutions University of California, San Diego

Vilayanur Subramanian Ramachandran (born August 10, 1951) is a neuroscientist known primarily for his work in the fields of behavioral neurology and visual psychophysics. He is currently a Professor in the Department of Psychology and the Graduate Program in Neurosciences at the University of California, San Diego.

Ramachandran is the author of several books that have garnered widespread public interest. These include Phantoms in the Brain (1998), "A Brief Tour of Human Consciousness" (2004) and The Tell-Tale Brain (2010). In addition to his books Ramachandran has presented keynote addresses and public lectures in the U.S., Canada, Britain, Australia and India. Ramachandran has appeared on a variety television interviews and many of his talks can be found on You Tube. He has been profiled in the New Yorker[1] and the Indian Swarajya Magazine.[2] Ramachandran has been called "The Marco Polo of neuroscience" by Richard Dawkins[3][4] and "the modern Paul Broca" by Eric Kandel.[4] In 1997, Newsweek named him as a member of the "Century Club" one of the most prominent people to watch in the next century.[5] In 2011, Time listed him as one of "the most influential people in the world" on the "Time 100 list".[6]

Early life and education[edit]

Vilayanur Subramanian Ramachandran (in accordance with some Tamil family name traditions, the town of his family's origin, Vilayanur, is placed first) was born in 1951 in Tamil Nadu, India, into a Brahmin family.[7][8] His father, V.M. Subramanian, was an engineer who worked for the U.N. Industrial Development Organization and served as a diplomat in Bangkok, Thailand.[9][1] As a young man Ramachandran attended schools in Madras, and British schools in Bangkok.[10] Ramachandran obtained an M.B.B.S. from the University of Madras in Chennai, India,[11] and subsequently obtained a Ph.D. from Trinity College at the University of Cambridge. He then spent two years at Caltech, as a research fellow working with Jack Pettigrew. He was appointed Assistant Professor of Psychology at the University of California, San Diego in 1983, and has been a full professor there since 1998.

Scientific career[edit]

Ramachandran's early research was on human visual perception using psychophysical methods to draw clear inferences about the brain mechanisms underlying visual processing. In the early 1990s Ramachandran began to focus on neurological syndromes such as phantom limbs, body integrity identity disorder and the Capgras delusion. He has also contributed to the understanding of synesthesia[1] and is known for inventing the mirror box. Ramachandran is noted for his use of experimental methods that make relatively little use of complex technologies such as neuroimaging. Despite the apparent simplicity of his approach, he has generated many new ideas about the brain.[12]

Ramachandran is the director of a research group at the University of California, San Diego, known as the Center for Brain and Cognition.[13][14] This group, made up of students and researchers from different universities, is affiliated with the Department of Psychology at UCSD. Members of the CBC have published articles on a range of topics related to neuroscience.[13]

Theories and research[edit]

Phantom limbs[edit]

When an arm or leg is amputated, patients often continue to feel vividly the presence of the missing limb as a "phantom limb" (an average of 80%). Building on earlier work by Ronald Melzack (McGill University) and Timothy Pons (NIMH), Ramachandran theorized that there was a link between the phenomenon of phantom limbs and neural plasticity in the adult human brain. In particular, he theorized that the body image maps in the somatosensory cortex are re-mapped after the amputation of a limb. In 1993, working with T.T. Yang who was conducting MEG research at the Scripps Research Institute,[15] Ramachandran demonstrated that there had been measurable changes in the somatosensory cortex of a patient who had undergone an arm amputation.[16][17] Ramachandran theorized that there was a relationship between the cortical reorganization evident in the MEG image and the referred sensations he had observed in other subjects.[18] Ramachandran believed that the non-painful referred sensations he observed were the "perceptual correlates" of cortical reorganization; however research by neuroscientists in Europe demonstrated that the cortical reorganization seen in MEG images was related to pain rather than non-painful referred sensations.[19] The question of which neural processes are related to non-painful referred sensations remains unresolved.

Mirror visual feedback[edit]

Ramachandran standing next to the original mirror box

Ramachandran is credited with the invention of the mirror box and the introduction of mirror visual feedback as a treatment for phantom limb paralysis. Ramachandran found that in some cases restoring movement to a paralyzed phantom limb reduced pain as well.[20] Small scale research studies using mirror therapy to treat phantom limb pain, stroke, and complex regional pain syndrome have produced promising results.[21] Although the effectiveness of mirror therapy in reducing pain was previously questioned,[22][23][24] there are now multiple controlled studies suggesting that not only is it effective in phantom limb pain and reflex sympathetic dystrophy, but that it is also a useful method of improving upper limb weakness after stroke.[25]

Projected images of the body during sleep paralysis[edit]

In 2014 Baland Jalal and V.S. Ramachandran published an article in Medical Hypotheses [26] in which they argued that the "bedroom intruder" often experienced during sleep paralysis may be related to the phenomenon of phantom limbs:

"We postulate that a functional disturbance of the right parietal cortex explains the shadowy nocturnal bedroom intruder hallucination during SP. This hallucination may arise due to a disturbance in the multisensory processing of body and self at the temporo-parietal junction. We specifically propose that this perceived intruder is the result of a hallucinated projection of the genetically ‘‘hard-wired’’ body image (homunculus), in the right parietal region...In short, this may explain why SP experiencers often see this human-like shadowy figure—a figure which usually fits the human morphology, in both size and shape."

Neural cross-wiring: synesthesia and metaphors[edit]

Synesthetes who experience color when viewing different symbols may quickly identify the presence of the "triangle" in the left-hand image.

Ramachandran has theorized that synesthesia arises from a cross-activation between brain regions.[27][28] One common form is called Grapheme-color synesthesia, where certain letters appear to be colored, or tinted. Ramachandran and his graduate student, Ed Hubbard, conducted research with functional magnetic resonance imaging that found increased activity in the color recognition areas of the brain in synesthetes compared to non-synesthetes.[28][29]

Ramachandran has speculated that synesthesia and conceptual metaphors may share a common basis in cortical cross-activation. In 2003 Ramachandran and Edward Hubbard published a paper in which they speculated that the angular gyrus is at least partially responsible for understanding metaphors.[30] More recently (2014), Baland Jalal and Ramachandran published a paper in which they speculated that there is evidence of "metaphor blindness" in a small subset of college students; "Metaphor blindness" refers to the reduced ability in otherwise normal individuals to comprehend metaphors of language, while showing no signs of other language deficits.[31]

Mirror neurons[edit]

Ramachandran is known for advocating the importance of mirror neurons. Ramachandran has stated that the discovery of mirror neurons is the most important unreported story of the last decade.[32] (Mirror neurons were first reported in a paper published in 1992 by a team of researchers led by Giacomo Rizzolatti at the University of Parma.[33]) In 2000, Ramachandran made a prediction that "mirror neurons will do for psychology what DNA did for biology: they will provide a unifying framework and help explain a host of mental abilities that have hitherto remained mysterious and inaccessible to experiments."[34][35]

Ramachandran has speculated that research into the role of mirror neurons will help explain a variety of human mental capacities such as empathy, imitation learning, and the evolution of language. Ramachandran has also theorized that mirror neurons may be the key to understanding the neurological basis of human self-awareness.[36][37]

A number of Ramachandran's ideas regarding mirror neurons have been challenged by neuroscientists. At this point, there is no scientific consensus about the role played by mirror neurons in humans.[38][39]

Broken Mirrors theory of autism[edit]

In 1999, Ramachandran, in collaboration with then post-doctoral fellow Eric Altschuler and colleague Jaime Pineda, was one of the first to suggest that a loss of mirror neurons might be the key deficit that explains many of the symptoms and signs of autism spectrum disorders.[40] Between 2000 and 2006 Ramachandran and his colleagues at UC San Diego published a number of articles in support of this theory, which became known as the "Broken Mirrors" theory of autism.[41][42][43] Ramachandran and his colleagues did not measure mirror neuron activity directly; rather they demonstrated that children with ASD showed abnormal EEG responses (known as Mu wave suppression) when they observed the activities of other people.

Ramachandran's speculation that dysfunctional mirror neuron systems (MNS) are the cause of autism remains controversial. In his 2011 review of The Tell-Tale Brain, Simon Baron-Cohen, Director of the Autism Research Center at Cambridge University, states that "As an explanation of autism, the [Broken Mirrors] theory offers some tantalizing clues; however, some problematic counter-evidence challenges the theory and particularly its scope."[44]

Neural basis of religious experience[edit]

In a 1997 Society for Neuroscience talk, Ramachandran hypothesized that there may be a neural basis for some religious experiences. He stated that "There may be dedicated neural machinery in the temporal lobes concerned with religion. This may have evolved to impose order and stability on society."[45] Ramachandran described an experiment in which he measured the galvanic skin responses of two subjects who had experienced temporal lobe seizures. Ramachandran measured the subjects' responses to a mixture of religious, sexual and neutral words and images and found that religious words and images elicited an unusually high response.[46] Ramachandran has also discussed his ideas about the neural basis of religion in a number of talks and in Phantoms In The Brain.[47] He cautions that his ideas are tentative, and so far he has not published any research on this subject.[48][49]

Rare neurological syndromes[edit]

Capgras delusion[edit]

In collaboration with William Hirstein, Ramachandran published a paper in 1997 in which he presented a theory regarding the neural basis of Capgras delusion, a delusion in which family members and other loved ones are thought to be replaced by impostors. Prior to Ramachandran's 1997 paper, psychologists HD Ellis and Andy Young had theorized that Capgras delusion was created by a neurological disconnection between facial recognition and emotional arousal.[50] Based on the evaluation of a single subject, who did not manifest complex psychological symptoms, Ramachandran and Hirstein hypothesized that Capgras delusion involves memory management problems, in addition to a disconnection between facial recognition and emotional arousal. According to their theory, a person suffering from Capgras delusion loses the ability to manage memories effectively.

Xenomelia (Apotemnophilia)[edit]

In 2008, Ramachandran, along with David Brang and Paul McGeoch, published the first paper to theorize that apotemnophilia is a neurological disorder caused by damage to the right parietal lobe of the brain.[51] This rare disorder, in which a person desires the amputation of a limb, was first identified by John Money in 1977. Building on medical case studies that linked brain damage to syndromes such as somatoparaphrenia (lack of limb ownership) the authors speculated that the desire for amputation could be related to changes in the right parietal lobe. In 2011 McGeoch, Brang and Ramachandran reported a functional imaging experiment involving four subjects who desired lower limb amputations. MEG scans demonstrated that their right superior parietal lobules were significantly less active in response to tactile stimulation of a limb that the subjects wished to have amputated, as compared to age/sex matched controls. [52] [53] The authors introduced the word "Xenomelia" to describe this syndrome, which is derived from the Greek for "foreign" and "limb".

Alternating gender incongruity (AGI)[edit]

In 2012, Case and Ramachandran reported the results of a survey of an atypical subset of bigender individuals who experience involuntary alternation between male and female states. Case and Ramachandran hypothesized that gender alternation may reflect an unusual degree (or depth) of hemispheric switching, and the corresponding suppression of sex appropriate body maps in the parietal cortex. They stated that "we hypothesize that tracking the nasal cycle, rate of binocular rivalry, and other markers of hemispheric switching will reveal a physiological basis for AGI individuals' subjective reports of gender switches...We base our hypotheses on ancient and modern associations between the left and right hemispheres and the male and female genders."[54][55][56]

Testimony at the Lisa Montgomery trial[edit]

In 2007, Ramachandran served as an expert witness on pseudocyesis (false pregnancy) at the trial of Lisa M. Montgomery. In 2004 Montgomery strangled Bobby Jo Stinnett until unconscious and then removed her unborn child with a knife. Ramachandran testified that Montgomery suffered from delusions created by severe pseudocyesis disorder and stated that she was not responsible for her actions. Federal prosecutor Roseann Ketchmark characterized Ramachandran's theory as "voodoo science."[57][58][59]

Awards and honors[edit]

Ramachandran was elected to a visiting fellowship at All Souls College, Oxford (1998–1999). In addition, he was a Hilgard visiting professor at Stanford University in 2005. He has received honorary doctorates from Connecticut College (2001) and the Indian Institute of Technology, Madras (2004).[60] Ramachandran received the annual Ramon y Cajal award (2004) from the International Neuropsychiatric Society,[61] and the Ariëns Kappers Medal from the Royal Netherlands Academy of Sciences for his contributions to Neuroscience (1999). He shared the 2005 Henry Dale Prize with Michael Brady of Oxford, and, as part of the award was elected an honorary life member of the Royal institution for "outstanding research of an interdisciplinary nature".[62] In 2007, the President of India conferred on him the third highest civilian award and honorific title in India, the Padma Bhushan.[63] In 2008, he was listed as number 50 in the Top 100 Public Intellectuals Poll.[64]

Minotaurasaurus ramachandrani[edit]

An interest in paleontology led Ramachandran to purchase a fossilised dinosaur skull originating from the Gobi Desert which, in 2009, was named after him as Minotaurasaurus ramachandrani.[65] A minor controversy surfaced around the provenance of this skull when claims were made that it was removed from the desert without permission and sold without proper documentation. Ramachandran, who purchased the fossil in Tucson, Arizona, says that he would be happy to repatriate the fossil to the appropriate nation if and when someone shows him "evidence it was exported without permit". In the meantime, the specimen is being kept at the Victor Valley Museum in Apple Valley, California.[66]

Books authored[edit]

See also[edit]

References[edit]

  1. ^ a b c Colapinto, J (May 11, 2009). "Brain Games; The Marco Polo of Neuroscience". The New Yorker. Archived from the original on March 10, 2011. Retrieved March 11, 2011. 
  2. ^ "VS Ramachandran: The Sherlock Holmes of Neuroscience". Retrieved 2017-08-20. 
  3. ^ Anthony, Andrew (2011-01-29). "VS Ramachandran: The Marco Polo of neuroscience". The Guardian. ISSN 0261-3077. Retrieved 2017-06-01. 
  4. ^ a b Ramachandran, Vilayanur. A brief tour of human consciousness. 
  5. ^ "The Century Club". Newsweek. 1997-04-20. Retrieved 2017-09-02. 
  6. ^ Insel, Thomas (2011-04-21). "The 2011 TIME 100 - TIME". Time. ISSN 0040-781X. Retrieved 2017-08-25. 
  7. ^ Andrew Anthony (January 30, 2011). "VS Ramachandran: The Marco Polo of neuroscience". guardian.co.uk. Retrieved December 11, 2014. 
  8. ^ Brain Games
  9. ^ The Science Studio Interview, June 10, 2006, transcript
  10. ^ Ramachandran V.S., The Making of a Scientist, essay included in Curious Minds:How a Child Becomes a Scientist, page 211 [1]
  11. ^ Caltech Catalog,1987-1988, page 325
  12. ^ Anthony, VS Ramachandran: The Marco Polo of neuroscience, The Observer, January 29, 2011.
  13. ^ a b http://cbc.ucsd.edu/research.html
  14. ^ Time, House of Neuroscience
  15. ^ Yang, UCSD Faculty web page Archived March 31, 2012, at the Wayback Machine.
  16. ^ Yang TT, Gallen CC, Ramachandran VS, Cobb S, Schwartz BJ, Bloom FE (February 1994). "Noninvasive detection of cerebral plasticity in adult human somatosensory cortex". NeuroReport. 5 (6): 701–4. PMID 8199341. doi:10.1097/00001756-199402000-00010. 
  17. ^ For a competing view, see: Flor et al., Nature Reviews, Vol 7, November 2006 [2][permanent dead link]
  18. ^ Ramachandran, Rogers-Ramachandran, Stewart, Perceptual correlates of massive cortical reorganization, Science, 1992, Nov 13, 1159-1160
  19. ^ Reprogramming the cerebral cortex: plasticity following central and peripheral lesions, Oxford, 2006, Edited by Stephen Lomber, pages 334
  20. ^ Ramachandran VS, Rogers-Ramachandran D (April 1996). "Synaesthesia in phantom limbs induced with mirrors". Proceedings of the Royal Society B. 263 (1369): 377–86. PMID 8637922. doi:10.1098/rspb.1996.0058. Retrieved 2008-09-23. [permanent dead link]
  21. ^ Chan, B; Witt, R; Charrow, A; Magee, A; Howard, R; Pasquina, P. Mirror Therapy for Phantom Limb Pain, N Engl J Med 2007; 357:2206–2207 November 22, 2007.
  22. ^ Flor, H, Maladaptive plasticity, memory for pain and phantom limb pain: review and suggestions for new therapies, Expert Reviews, Neurotherapeutics,8(5) 2008,[3]
  23. ^ Moseley, L; Flor, H. Targeting Cortical Representations in the Treatment of Chronic Pain: A Review Archived May 13, 2012, at the Wayback Machine., Neurorehabilitation & Neural Repair, XX(X) 1–7, 2012.
  24. ^ Rothgangel, AS; Braun, SM; Beurskens, AJ; Seitz, RJ; Wade, DT (March 2011). "The clinical aspects of mirror therapy in rehabilitation: a systematic review of the literature". Int J Rehabil Res. 34: 1–13. PMID 21326041. doi:10.1097/MRR.0b013e3283441e98. 
  25. ^ http://cbc.ucsd.edu/mirrorfeedback_citations.pdf
  26. ^ Jalal, Baland; Ramachandran, Vilayanur S. (2014-12-01). "Sleep paralysis and "the bedroom intruder": The role of the right superior parietal, phantom pain and body image projection". Medical Hypotheses. 83 (6): 755–757. doi:10.1016/j.mehy.2014.10.002. 
  27. ^ Ramachandran VS & Hubbard EM (2001). "Synaesthesia: A window into perception, thought and language" (PDF). Journal of Consciousness Studies. 8 (12): 3–34. 
  28. ^ a b Hubbard EM, Arman AC, Ramachandran VS, Boynton GM (March 2005). "Individual differences among grapheme-color synesthetes: brain-behavior correlations" (PDF). Neuron. 45 (6): 975–85. PMID 15797557. doi:10.1016/j.neuron.2005.02.008. Retrieved 2011-04-21. 
  29. ^ Hubbard EM, Ramachandran VS (2005). "Neurocognitive mechanisms of synesthesia" (PDF). Neuron. 48 (3): 509–520. PMID 16269367. doi:10.1016/j.neuron.2005.10.012. 
  30. ^ Ramachandran, Hubbard, "Neural cross wiring and synesthesia", Journal of Vision, Dec 2000 [4]
  31. ^ Jalal, Baland; Ramachandran, Vilayanur S. (2014-06-01). "A pilot investigation of "metaphor blindness" in a college student population". Medical Hypotheses. 82 (6): 648–651. doi:10.1016/j.mehy.2014.01.033. 
  32. ^ Ramachandran, V.S. (June 1, 2000). "Mirror neurons and imitation learning as the driving force behind "the great leap forward" in human evolution". Edge Foundation web site. Retrieved October 19, 2011. 
  33. ^ Rizzolatti, G., Fabbri-Destro, M, "Mirror Neurons: From Discovery to Autism" Experimental Brain Research, (2010)200:223–237 [5]
  34. ^ Jarrett Christian, Brain Myths, Psychology Today, December 10,2012
  35. ^ Baron-Cohen, Making Sense of the Brain's Mysteries, American Scientist, On-line Book Review, July–August, 2011 [6]
  36. ^ Oberman, L.M. & Ramachandran, V.S. (2008). "Reflections on the Mirror Neuron System: Their Evolutionary Functions Beyond Motor Representation". In Pineda, J. A. Mirror Neuron Systems: The Role of Mirroring Processes in Social Cognition. Contemporary Neuroscience. Humana Press. pp. 39–62. ISBN 978-1-934115-34-3. 
  37. ^ Ramachandran, V.S. (January 1, 2009). "Self Awareness: The Last Frontier". Edge Foundation web site. Retrieved October 19, 2011. 
  38. ^ Brain Watch, Dec 13,2013
  39. ^ Jarrett, Christian, Psychology Today, Dec 12,2012[7]
  40. ^ E.L. Altschuler, A. Vankov, E.M. Hubbard, E. Roberts, V.S. Ramachandran and J.A. Pineda (2000). "Mu wave blocking by observer of movement and its possible use as a tool to study theory of other minds". 30th Annual Meeting of the Society for Neuroscience. Society for Neuroscience. 
  41. ^ Oberman LM, Hubbard EM, McCleery JP, Altschuler EL, Ramachandran VS, Pineda JA (2005). "EEG evidence for mirror neuron dysfunction in autism spectrum disorders" (PDF). Cognitive Brain Research. 24 (2): 190–198. PMID 15993757. doi:10.1016/j.cogbrainres.2005.01.014. Archived from the original (PDF) on 2012-04-19. 
  42. ^ Ramachandran, V.S. & Oberman, L.M. (October 16, 2006). "Broken Mirrors: A Theory of Autism" (PDF). Scientific American. 295 (5): 62–69. PMID 17076085. doi:10.1038/scientificamerican1106-62. 
  43. ^ Oberman LM & Ramachandran VS (2007). "The simulating social mind: the role of the mirror neuron system and simulation in the social and communicative deficits of autism spectrum disorders" (PDF). Psychological Bulletin. 133 (2): 310–327. PMID 17338602. doi:10.1037/0033-2909.133.2.310. Archived from the original (PDF) on 2012-04-19. 
  44. ^ Baron-Cohen, Simon,"Making Sense of the Brain's Mysteries, American Scientist, On-line Book Review, July–August,2011 [8]
  45. ^ Times of London, 1997
  46. ^ Scientific nautalism and the neurology of religious experience, Ratcliffe, Matthew, University of Durham, 2003,[9]
  47. ^ Phantoms In The Brain, Chapter 9
  48. ^ Youtube talk at the Salk Institute
  49. ^ Independent.co.uk Website
  50. ^ Ellis MD, Young, Accounting for delusional misidentifications, British Journal of Psychiatry, Aug 1990, 239-248 [10]
  51. ^ Brang, D McGeoch, P & Ramachandran VS (2008). "Apotemnophilia: A Neurological Disorder" (PDF). Cognitive Neuroscience and Neuropsychology. 19: 1305–1306. PMID 18695512. doi:10.1097/WNR.0b013e32830abc4d. 
  52. ^ McGeoch, Paul, Xenomelia: a new right parietal lobe syndrome, Journal of Neurology, Neurosurgery, and Psychiatry, June 21, 2011 [11]
  53. ^ Brugger, Peter, Xenomelia: A Social Neuroscience View of Altered Bodily Self-Consciousness, Frontiers in Psychology, April 24, 2013 [12]
  54. ^ Case, L. K.; Ramachandran, V. S. (2012). "Alternating gender incongruity: A new neuropsychiatric syndrome providing insight into the dynamic plasticity of brain-sex". Medical Hypotheses. 78 (5): 626–631. PMID 22364652. doi:10.1016/j.mehy.2012.01.041. 
  55. ^ "Bigender — Boy Today, Girl Tomorrow?". Neuroskeptic. April 8, 2012. 
  56. ^ Stix, Gary (2012-04-20). "'Alternating Gender Incongruity' Causes Rapid Shifts Of Gender, Scientist Claims". The Huffington Post. 
  57. ^ Karen Olson (October 21, 2007). "Brain Expert Witness Testifies in Lisa Montgomery Trial". Expert Witness Blog, Juris Pro. Retrieved November 21, 2011. 
  58. ^ "United States of America v. Lisa M. Montgomery". American Lawyer. April 7, 2011. Retrieved November 21, 2011. 
  59. ^ BBC News, One-Minute World News, Tuesday, 23 October 2007
  60. ^ Science Direct, 2 January 2007 Archived July 26, 2011, at the Wayback Machine.
  61. ^ INA web site
  62. ^ [13]
  63. ^ Search on "Archived copy". Archived from the original on January 31, 2009. Retrieved January 31, 2009.  for Ramachandaran (sic!) in March 2008.
  64. ^ "Intellectuals". Prospect Magazine. 2009. Archived from the original on September 30, 2009. Retrieved June 4, 2011. 
  65. ^ Miles, Clifford A. & Clark J. Miles (2009). "Skull of Minotaurasaurus ramachandrani, a new Cretaceous ankylosaur from the Gobi Desert" (PDF). Current Science. 96 (1): 65–70. 
  66. ^ naturenews, February 2, 2009

External links[edit]