VAMP4

From Wikipedia, the free encyclopedia
Jump to: navigation, search
VAMP4
Protein VAMP4 PDB 2nps.png
Identifiers
Aliases VAMP4, VAMP-4, VAMP24, vesicle associated membrane protein 4
External IDs MGI: 1858730 HomoloGene: 37847 GeneCards: VAMP4
RNA expression pattern
PBB GE VAMP4 207350 s at fs.png

PBB GE VAMP4 213480 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001185127
NM_003762
NM_201994

NM_016796
NM_001347125

RefSeq (protein)

NP_001172056
NP_003753

NP_001334054
NP_058076

Location (UCSC) Chr 1: 171.7 – 171.74 Mb Chr 1: 162.57 – 162.6 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.[3][4]

Function[edit]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.[4]

Interactions[edit]

VAMP4 has been shown to interact with AP1M1,[5] STX6[6] and STX16.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH (Apr 1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". The Journal of Biological Chemistry. 273 (17): 10317–24. doi:10.1074/jbc.273.17.10317. PMID 9553086. 
  4. ^ a b "Entrez Gene: VAMP4 vesicle-associated membrane protein 4". 
  5. ^ Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Reports. 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMC 1326413Freely accessible. PMID 14608369. 
  6. ^ a b Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079Freely accessible. PMID 11839770. 

Further reading[edit]