VAPA

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VAPA
Protein VAPA PDB 1z9l.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases VAPA, VAP-33, VAP-A, VAP33, hVAP-33, VAMP associated protein A
External IDs MGI: 1353561 HomoloGene: 37824 GeneCards: VAPA
Gene location (Human)
Chromosome 18 (human)
Chr. Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for VAPA
Genomic location for VAPA
Band 18p11.22 Start 9,914,002 bp[1]
End 9,960,021 bp[1]
RNA expression pattern
PBB GE VAPA 208780 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003574
NM_194434

NM_013933
NM_001355402

RefSeq (protein)

NP_003565
NP_919415

NP_038961
NP_001342331

Location (UCSC) Chr 18: 9.91 – 9.96 Mb Chr 18: 65.58 – 65.61 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Vesicle-associated membrane protein-associated protein A is a protein that in humans is encoded by the VAPA gene.[5][6][7] Together with VAPB it forms the VAP protein family.

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.[7]

Interactions[edit]

VAPA has been shown to interact with OSBP.[8] This interaction is mediated by the FFAT motif in OSBP.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101558 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024091 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Nishimura Y, Hayashi M, Inada H, Tanaka T (Feb 1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins". Biochem Biophys Res Commun. 254 (1): 21–6. PMID 9920726. doi:10.1006/bbrc.1998.9876. 
  6. ^ Weir ML, Klip A, Trimble WS (Sep 1998). "Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP". Biochem J. 333 (2): 247–51. PMC 1219579Freely accessible. PMID 9657962. doi:10.1042/bj3330247. 
  7. ^ a b "Entrez Gene: VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa". 
  8. ^ Wyles, Jessica P; McMaster Christopher R; Ridgway Neale D (Aug 2002). "Vesicle-associated membrane protein-associated protein-A (VAP-A) interacts with the oxysterol-binding protein to modify export from the endoplasmic reticulum". J. Biol. Chem. United States. 277 (33): 29908–18. ISSN 0021-9258. PMID 12023275. doi:10.1074/jbc.M201191200. 

Further reading[edit]