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Protein VAV2 PDB 2dlz.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesVAV2, VAV-2, vav guanine nucleotide exchange factor 2
External IDsOMIM: 600428 MGI: 102718 HomoloGene: 2530 GeneCards: VAV2
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 9: 133.76 – 133.99 MbChr 2: 27.26 – 27.43 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.[5][6]

VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.[6]


VAV2 has been shown to interact with CD19[7] and Grb2.[8][9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160293 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009621 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Henske EP, Short MP, Jozwiak S, Bovey CM, Ramlakhan S, Haines JL, Kwiatkowski DJ (June 1995). "Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1". Ann Hum Genet. 59 (Pt 1): 25–37. doi:10.1111/j.1469-1809.1995.tb01603.x. PMID 7762982. S2CID 27548854.
  6. ^ a b "Entrez Gene: VAV2 vav 2 oncogene".
  7. ^ Doody, G M; Billadeau D D; Clayton E; Hutchings A; Berland R; McAdam S; Leibson P J; Turner M (November 2000). "Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes". EMBO J. 19 (22): 6173–84. doi:10.1093/emboj/19.22.6173. ISSN 0261-4189. PMC 305817. PMID 11080163.
  8. ^ Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. S2CID 26838266.
  9. ^ Bourguignon, L Y; Zhu H; Zhou B; Diedrich F; Singleton P A; Hung M C (Dec 2001). "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth". J. Biol. Chem. 276 (52): 48679–92. doi:10.1074/jbc.M106759200. ISSN 0021-9258. PMID 11606575.

Further reading[edit]

External links[edit]

  • Overview of all the structural information available in the PDB for UniProt: P52735 (Guanine nucleotide exchange factor VAV2) at the PDBe-KB.