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Aliases VCX, VCX-10r, VCX-B1, VCX1, VCX10R, VCXB1, variable charge, X-linked
External IDs HomoloGene: 88395 GeneCards: VCX
RNA expression pattern
PBB GE VCX 211403 x at fs.png

PBB GE VCX 207281 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr X: 7.84 – 7.84 Mb n/a
PubMed search [1] n/a
View/Edit Human

Variable charge X-linked protein 1 is a protein that in humans is encoded by the VCX gene.[2][3][4]

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.[4]


  1. ^ "Human PubMed Reference:". 
  2. ^ Lahn BT, Page DC (Feb 2000). "A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins". Hum Mol Genet. 9 (2): 311–9. doi:10.1093/hmg/9.2.311. PMID 10607842. 
  3. ^ Fukami M, Kirsch S, Schiller S, Richter A, Benes V, Franco B, Muroya K, Rao E, Merker S, Niesler B, Ballabio A, Ansorge W, Ogata T, Rappold GA (Sep 2000). "A Member of a Gene Family on Xp22.3, VCX-A, Is Deleted in Patients with X-Linked Nonspecific Mental Retardation". Am J Hum Genet. 67 (3): 563–73. doi:10.1086/303047. PMC 1287516Freely accessible. PMID 10903929. 
  4. ^ a b "Entrez Gene: VCX variable charge, X-linked". 

Further reading[edit]