Mitochondrial antiviral-signaling protein

From Wikipedia, the free encyclopedia
  (Redirected from VISA (gene))
Jump to navigation Jump to search
MAVS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAVS, CARDIF, IPS-1, IPS1, VISA, mitochondrial antiviral signaling protein
External IDsMGI: 2444773 HomoloGene: 17004 GeneCards: MAVS
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for MAVS
Genomic location for MAVS
Band20p13Start3,846,799 bp[1]
End3,876,123 bp[1]
RNA expression pattern
PBB GE VISA gnf1h08694 at fs.png

PBB GE VISA gnf1h08693 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206491
NM_020746

NM_001206382
NM_001206383
NM_001206385
NM_144888

RefSeq (protein)

NP_001193420
NP_065797

NP_001193311
NP_001193312
NP_001193314
NP_659137

Location (UCSC)Chr 20: 3.85 – 3.88 MbChr 2: 131.23 – 131.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial antiviral-signaling protein (MAVS) is a protein that in humans is encoded by the MAVS gene.[5][6][7] The protein is also known by the names VISA (virus-induced signaling adapter), IPS-1 and Cardif. Aggregated MAVS forms protease resistant prion-like aggregates that activate IRF3 dimerization.[8]

Function[edit]

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIG-I. These interactions initiate signalling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB; MIM 603258), which activate NF-κB, or TBK1 and IKBKE, which activate IRF3. Activated IRF3 and NF-κB induce transcription of IFNβ (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIG-I, the intermediary protein is mitochondria-bound MAVS.[7][9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000088888 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037523 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Seth RB, Sun L, Ea CK, Chen ZJ (Sep 2005). "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3". Cell. 122 (5): 669–82. doi:10.1016/j.cell.2005.08.012. PMID 16125763.
  6. ^ Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB (Sep 2005). "VISA is an adapter protein required for virus-triggered IFN-beta signaling". Mol Cell. 19 (6): 727–40. doi:10.1016/j.molcel.2005.08.014. PMID 16153868.
  7. ^ a b "Entrez Gene: VISA virus-induced signaling adapter".
  8. ^ Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ (Aug 5, 2011). "MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response". Cell. 146 (3): 448–61. doi:10.1016/j.cell.2011.06.041. PMC 3179916. PMID 21782231.
  9. ^ Sen GC, Sarkar SN (2005). "Hitching RIG to action". Nat. Immunol. 6 (11): 1074–6. doi:10.1038/ni1105-1074. PMID 16239922.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.