Vacuolar protein sorting-associated protein 33B is a protein that in humans is encoded by the VPS33Bgene.
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
Carim L, Sumoy L, Andreu N et al. (2000). "Cloning, mapping and expression analysis of VPS33B, the human orthologue of rat Vps33b.". Cytogenet. Cell Genet.89 (1-2): 92–5. doi:10.1159/000015571. PMID10894945.CS1 maint: Explicit use of et al. (link)
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.CS1 maint: Explicit use of et al. (link)
Gissen P, Johnson CA, Morgan NV et al. (2004). "Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome.". Nat. Genet.36 (4): 400–4. doi:10.1038/ng1325. PMID15052268.CS1 maint: Explicit use of et al. (link)
Gissen P, Johnson CA, Gentle D et al. (2005). "Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights.". Hum. Mol. Genet.14 (10): 1261–70. doi:10.1093/hmg/ddi137. PMID15790593.CS1 maint: Explicit use of et al. (link)
Lo B, Li L, Gissen P et al. (2006). "Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis.". Blood106 (13): 4159–66. doi:10.1182/blood-2005-04-1356. PMID16123220.CS1 maint: Explicit use of et al. (link)
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.CS1 maint: Explicit use of et al. (link)