VPS45

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VPS45
Identifiers
Aliases VPS45, H1, H1SCN5, VPS45A, VPS45B, VPS54A, VSP45, VSP45A, vacuolar protein sorting 45 homolog
External IDs MGI: 891965 HomoloGene: 5250 GeneCards: VPS45
RNA expression pattern
PBB GE VPS45 209268 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001279353
NM_001279354
NM_001279355
NM_007259

NM_013841

RefSeq (protein)

NP_001266282
NP_001266283
NP_001266284
NP_009190

NP_038869.1
NP_038869

Location (UCSC) Chr 1: 150.07 – 150.15 Mb Chr 3: 96 – 96.06 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Vacuolar protein sorting-associated protein 45 is a protein that in humans is encoded by the VPS45 gene.[3][4]

Function[edit]

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Pevsner J, Hsu SC, Hyde PS, Scheller RH (Feb 1997). "Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking". Gene. 183 (1-2): 7–14. doi:10.1016/S0378-1119(96)00367-8. PMID 8996080. 
  4. ^ a b "Entrez Gene: VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)". 

Further reading[edit]