VRK1

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VRK1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases VRK1, PCH1, PCH1A, vaccinia related kinase 1
External IDs MGI: 1261847 HomoloGene: 2541 GeneCards: VRK1
RNA expression pattern
PBB GE VRK1 203856 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003384

NM_001029843
NM_001029844
NM_011705

RefSeq (protein)

NP_003375

Location (UCSC) Chr 14: 96.8 – 96.93 Mb Chr 12: 106.01 – 106.08 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene.[3][4]

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nezu J, Oku A, Jones MH, Shimane M (Feb 1998). "Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase". Genomics. 45 (2): 327–31. doi:10.1006/geno.1997.4938. PMID 9344656. 
  4. ^ a b "Entrez Gene: VRK1 vaccinia related kinase 1". 

Further reading[edit]