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Available structures
PDBOrtholog search: PDBe RCSB
AliasesVRK1, PCH1, PCH1A, vaccinia related kinase 1, VRK serine/threonine kinase 1
External IDsOMIM: 602168 MGI: 1261847 HomoloGene: 2541 GeneCards: VRK1
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for VRK1
Genomic location for VRK1
Band14q32.2Start96,797,382 bp[1]
End96,931,722 bp[1]
RNA expression pattern
PBB GE VRK1 203856 at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 14: 96.8 – 96.93 MbChr 12: 106.01 – 106.08 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse
Cartoon diagram of the Human vaccinia-related kinase protein PDB entry 6bru

Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene.[5][6]

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and C-jun.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100749 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021115 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nezu J, Oku A, Jones MH, Shimane M (Feb 1998). "Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase". Genomics. 45 (2): 327–31. doi:10.1006/geno.1997.4938. PMID 9344656.
  6. ^ a b "Entrez Gene: VRK1 vaccinia related kinase 1".

Further reading[edit]