Val Murray Runge

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Val M. Runge
Runge figure garmish.jpg
Born (1956-08-28) August 28, 1956 (age 65)
Alma materStanford University, Stanford University School of Medicine, Vanderbilt University Medical Center, University of Bern
Scientific career
InstitutionsUniversity of Bern

Val Murray Runge (born August 28, 1956 in Austin, Texas) is an American professor of radiology and the editor-in-chief of Investigative Radiology.[1] Runge was one of the early researchers to investigate the use of gadolinium-based contrast agents for magnetic resonance imaging (MRI),[2] giving the first presentation in this field (in 1982),[3] followed two years later by the first presentation of efficacy (in 1984).[4] His research also pioneered many early innovations in MRI, including the use of tilted planes (for standardization of brain imaging, in 1987) and respiratory gating (for liver imaging, in 1984).[5][6] His publication on multiple sclerosis in 1984 represented the third and largest clinical series (to that date) investigating the role of MRI in this disease, and the first to show characteristic abnormalities on MRI in patients whose CT was negative.[7]


Runge was born in Austin, Texas and graduated from Stanford University with a Bachelor of Science, with honors, in Chemistry in June 1978. He subsequently received his MD from Stanford University School of Medicine in January 1982. Following completion of a diagnostic radiology residency at Vanderbilt University Medical Center in December 1985, Runge was appointed as assistant professor and chief of service of magnetic resonance at Tufts University School of Medicine in 1986. He was promoted to associate professor in 1988. In 1990 he was appointed professor of diagnostic radiology and biomedical engineering, Director of the Magnetic Resonance Imaging and Spectroscopy Center, and the Rosenbaum Endowed Chair of Diagnostic Radiology, at the University of Kentucky Medical Center. In 2002, Runge was appointed the Robert and Alma Moreton Centennial Chair in Radiology, Scott & White Memorial Hospital, and professor of radiology at the Texas A&M Health Science Center. In 2010 he was appointed the John Sealy Distinguished Chair and Professor of Radiology at the University of Texas Medical Branch in Galveston. In 2011, he received an additional honorary appointment as visiting professor, for 2012–2015, from Tongji Medical College, Wuhan, Central China. Runge then spent two years in Zurich, Switzerland as a visiting professor at the University Hospital of Zürich (2013-2015). Runge lives currently in Bern, Switzerland, having a long-term appointment as a member of the faculty at Inselspital, Universitätsspital Bern. He received the title of Prof. Dr. from the University of Bern in 2019.

Scientific career[edit]

Runge is an early pioneer in MRI, known for his work in 1982-1984 demonstrating for the first time the potential as well as early diagnostic utility of intravenous contrast media in MRI, specifically the gadolinium chelates.[5][8][9][10]

He is an author of more than 230 peer-reviewed papers published in the scientific literature. He is also the editor for nineteen medical textbooks,[11][12][13][14][15][16][17] with several of these translated into other languages, including German,[18][19] Chinese, Polish and Turkish. His most recent textbooks are "Neuroradiology - the Essentials with MR and CT",[20] "Imaging of Cerebrovascular Disease",[21] and "The Physics of Clinical MR Taught Through Images",[22] all published by Thieme (with copyrights of 2015, 2017 and 2018), and in 2019 the second edition of "Essentials of Clinical MR".[23] He has given more than 800 scientific and invited presentations at national and international meetings and medical schools across North America, Europe, Australia, Japan, Korea and China over the past 38 years.

Runge holds a U.S. patent (#4615879), together with Jeffrey A. Clanton, for oral particulate NMR contrast agents.[24]

Current activities[edit]

Since 1994, Runge has been editor-in-chief of Investigative Radiology. He has also been a member of the editorial boards of the Journal of Magnetic Resonance Imaging and Topics in Magnetic Resonance Imaging since their respective inceptions, in 1991 and 1988. He remains active in research and development of MRI contrast agents and advanced MRI imaging techniques. In 2019, under his guidance, the first study demonstrating the toxicity of gadolinium chelates to brain tissue was published.[25] This identifies a pathway by which linear gadolinium chelates may produce ill effects in otherwise normal patients long after injection, supporting the EMA's decision in 2017 to withdraw certain, and restrict other, agents in this category from clinical use. Runge also maintains an educational website (, for which international experts in MRI provide insights on imaging techniques and strategies.

Awards and membership[edit]

He was elected Fellow of the International Society for Magnetic Resonance in Medicine in 1990. In 2011, Runge received the Harry Fisher Medal for Excellence in Contrast Media Research from the Contrast Media Research Society.[26]

Other academic honors include the Executive Council Award from the American Roentgen Ray Society (for research in MRI and multiple sclerosis),[27] the Dyke Memorial Award from the American Society of Neuroradiology (for MR contrast media research),[28] and a Magna Cum Laude Award (for the best scientific exhibit) from the Radiological Society of North America.[29] He is a diplomate of the American Board of Radiology (1986).

Private life[edit]

Runge has two daughters and currently resides in Bern, Switzerland's capital.


  1. ^ "Editorial Board". Investigative Radiology. Lippincott Williams & Wilkins. Retrieved 2013-10-13.
  2. ^ Runge VM, Schoerner W, Niendorf HP, Laniado M, Koehler D, Claussen C, Felix R, James AE; Schoerner; Niendorf; Laniado; Koehler; Claussen; Felix; James Jr (1985). "Initial clinical evaluation of gadolinium DTPA for contrast-enhanced magnetic resonance imaging". Magnetic Resonance Imaging. 3 (1): 27–35. doi:10.1016/0730-725x(85)90006-2. PMID 2987640.CS1 maint: multiple names: authors list (link)
  3. ^ Runge VM, Stewart RG, Clanton JA, James AE, Partain CL. Paramagnetic NMR contrast agents: Potential oral and intravenous agents. Work-in-progress, Radiological Society of North America, November 1982.
  4. ^ Runge VM, Clanton JA, Price AC, Herzer WA, Allen JH, Partain CL, James AE: Contrast enhanced magnetic resonance evaluation of a brain abscess model. 1984 Cornelius G. Dyke Memorial Award. 22nd Annual Meeting of the American Society of Neuroradiology, June 1984. American Journal of Neuroradiology 1984; 5:677.
  5. ^ a b Runge VM, Osborne MA, Wood ML, Wolpert SM, Kwan E, Kaufman DM (1987). "The efficacy of tilted axial MRI of the CNS". Magnetic Resonance Imaging. 5 (6): 421–30. doi:10.1016/0730-725X(87)90376-6. PMID 3431352.CS1 maint: multiple names: authors list (link)
  6. ^ Runge VM, Clanton JA, Partain CL, James AE Jr. (1984). "Respiratory gating in magnetic resonance imaging at 0.5 Tesla". Radiology. 151 (2): 521–3. doi:10.1148/radiology.151.2.6709928. PMID 6709928.CS1 maint: multiple names: authors list (link)
  7. ^ Runge VM, Clanton JA, Partain CL, James AE Jr. (1984). "Magnetic resonance imaging of multiple sclerosis: a study of pulse-technique efficacy". American Journal of Roentgenology. 143 (5): 1015–26. doi:10.2214/ajr.143.5.1015. PMID 6333143.CS1 maint: multiple names: authors list (link)
  8. ^ Runge VM, Clanton JA, Price AC, Wehr CJ, Herzer WA, Partain CL, James AE; Clanton; Price; Wehr; Herzer; Partain; James Jr (1985). "The use of Gd DTPA as a perfusion agent and marker of blood-brain barrier disruption". Magnetic Resonance Imaging. 3 (1): 43–55. doi:10.1016/0730-725x(85)90008-6. PMID 3923292.CS1 maint: multiple names: authors list (link)
  9. ^ Runge VM, Clanton JA, Foster MA, Smith FW, Lukehart CM, Jones MM, Partain CL, James AE; Clanton; Foster; Smith; Lukehart; Jones; Partain; James Jr (1984). "Paramagnetic NMR contrast agents. Development and evaluation". Investigative Radiology. 19 (5): 408–15. doi:10.1097/00004424-198409000-00013. PMID 6439672.CS1 maint: multiple names: authors list (link)
  10. ^ Runge VM, Clanton JA, Herzer WA, Gibbs SJ, Price AC, Partain CL, James AE; Clanton; Herzer; Gibbs; Price; Partain; James Jr (October 1984). "Intravascular contrast agents suitable for magnetic resonance imaging". Radiology. 153 (1): 171–6. doi:10.1148/radiology.153.1.6433402. PMID 6433402.CS1 maint: multiple names: authors list (link)
  11. ^ "Clinical MRI / Edition 1 by Val M. Runge | 9780721680361 | Hardcover | Barnes & Noble". Retrieved 2013-10-13.
  12. ^ Thieme Medical Publishers | The Physics of Clinical MR Taught Through Images. 2018. ISBN 9781626234277. Retrieved 2013-10-13.
  13. ^ "Thieme Medical Publishers | The Cerefy Atlas of Cerebral Vasculature/CD-ROM". Retrieved 2013-10-13.
  14. ^ "Thieme Medical Publishers | Essentials of Clinical MR". Retrieved 2013-10-13.
  15. ^ "Thieme Medical Publishers | Clinical 3T Magnetic Resonance". Retrieved 2013-10-13.
  16. ^ Runge, Val M (1992). Magnetic resonance imaging: Clinical principles. ISBN 9780397510955.
  17. ^ Runge, Val M (1994). Magnetic Resonance Imaging of the Brain. ISBN 9780397512447.
  18. ^ "Praxiskurs MRT - - Thieme Webshop" (in German). Retrieved 2013-10-13.
  19. ^ "Essentials der klinischen MRT - - Thieme Webshop" (in German). Retrieved 2013-10-13.
  20. ^ Runge, Val M.; Smoker, Wendy R. K.; Valavanis, Anton (11 December 2014). Neuroradiology. ISBN 9781604069167.
  21. ^ Runge, Val M. (2016). Imaging of Cerebrovascular Disease. ISBN 9781626232488.
  22. ^ Runge, Val M.; Nitz, Wolfgang R.; Heverhagen, Johannes T. (2018). The Physics of Clinical MR Taught Through Images. ISBN 9781626234277.
  23. ^ Essentials of Clinical MR, 2nd edition.
  24. ^ "Patent US4615879 - Particulate NMR contrast agents for gastrointestinal application - Google Patents". Retrieved 2013-10-13.
  25. ^ Bower DV, Richter JK, von Tengg-Kobligk H, Heverhagen JT, Runge VM (2019). "Gadolinium-Based MRI Contrast Agents Induce Mitochondrial Toxicity and Cell Death in Human Neurons, and Toxicity Increases with Reduced Kinetic Stability of the Agent". Investigative Radiology. 54 (8): 453–463. doi:10.1097/RLI.0000000000000567. PMID 31265439.CS1 maint: multiple names: authors list (link)
  26. ^ "Shining Stars | Impact Newsletter: November 1, 2011 | UTMB". 2011-11-01. Retrieved 2013-10-13.
  27. ^ Runge VM, Price AC, Kirschner HS, Allen JH, Partain CL, James AE Jr. The evaluation of multiple sclerosis by magnetic resonance imaging. Presented at the 84th Annual Meeting of the American Roentgen Ray Society, April 1984. Executive Council Award.
  28. ^ "ASNR's Cornelius G. Dyke Memorial Award". ASNR. Retrieved 2013-10-13.
  29. ^ Runge VM, Clanton JA, Price AC, Herzer WA, Wehr CJ, Schoerner VW, Felix R, Partain CL, James AE. Contrast enhanced magnetic resonance imaging of the brain: experimental and clinical investigation with Gd DTPA. 70th Annual Meeting of the Radiological Society of North America. Radiology 1984; 153:343.