Menthyl isovalerate

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Menthyl isovalerate
Menthyl isovalerate.svg
IUPAC name
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 3-methylbutanoate
Other names
Validolum; Valofin; Validol; Menthoval
3D model (JSmol)
ECHA InfoCard 100.036.766
Molar mass 240.387 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Menthyl isovalerate, also known as validolum, is the menthyl ester of isovaleric acid. It is a transparent oily, colorless liquid with a smell of menthol. It is very slightly soluble in ethanol, while practically insoluble in water. It is used as a food additive for flavor and fragrance.[1]

Medical use[edit]

In the former Soviet Union states including Russia, menthyl isovalerate is sold as an anxiolytic under various trade names including Validol, Valofin, and Menthoval.[2][3][4]

See also[edit]


  1. ^ Menthyl isovalerate
  2. ^ Russian Medications List and Possible Side Effects
  3. ^ "Farmak Product Information - Validol" (PDF). Archived from the original (PDF) on 2016-03-15. Retrieved 2013-04-05.
  4. ^ Bondarenko IP, Liashenko MM, Chirkov SN, Ermakovich II (1996). "A comparative evaluation of the antianginal action of commercially and noncommercially produced validol in neurocirculatory dystonia and stenocardia". Lik Sprava. Mar-Apr (3–4): 110–113. PMID 9035841.