Menthyl isovalerate

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Menthyl isovalerate
Menthyl isovalerate.svg
IUPAC name
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 3-methylbutanoate
Other names
Validolum; Valofin; Validol; Menthoval
3D model (Jmol)
ECHA InfoCard 100.036.766
Molar mass 240.39 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Menthyl isovalerate, also known as validolum, is the menthyl ester of isovaleric acid. It is a transparent oily, colorless liquid with a smell of menthol. It is very slightly soluble in ethanol, while practically insoluble in water. It is used as a food additive for flavor and fragrance.[1]

Medical use[edit]

In the former Soviet Union states including Russia, validolum is sold as an anxiolytic under the trade name Validol. Other brand names may include Valofin and Menthoval. It is also used for sedation during hysteria, cardiac chest pain, and nausea.[2][3][4]

See also[edit]


  1. ^ Menthyl isovalerate
  2. ^ Russian Medications List and Possible Side Effects
  3. ^ Farmak Product Information - Validol
  4. ^ Bondarenko IP, Liashenko MM, Chirkov SN, Ermakovich II (1996). "A comparative evaluation of the antianginal action of commercially and noncommercially produced validol in neurocirculatory dystonia and stenocardia". Lik Sprava. Mar-Apr (3-4): 110–113. PMID 9035841.