|62nd President of the Royal Society|
1 December 2015 – 30 November 2020
|Preceded by||Paul Nurse|
|Succeeded by||Adrian Smith|
1952 (age 69–70)
Chidambaram, Tamil Nadu, India
|Education||Convent of Jesus and Mary Baroda|
|Thesis||The Green Function Theory of the Ferroelectric Phase Transition in Potassium Dihydrogen-Phosphate (1976)|
|Doctoral advisor||Tomoyasu Tanaka|
Venkatraman Ramakrishnan (born 1952) is an Indian-born British and American structural biologist who shared the 2009 Nobel Prize in Chemistry with Thomas A. Steitz and Ada Yonath, "for studies of the structure and function of the ribosome".
Since 1999, he has worked as a group leader at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) on the Cambridge Biomedical Campus, UK and is a Fellow of Trinity College, Cambridge. He served as President of the Royal Society from 2015 to 2020.
Education and early life
Ramakrishnan was born in a Tamil family of Chidambaram in Cuddalore district of Tamil Nadu, India to C. V. Ramakrishnan and Rajalakshmi Ramakrishnan. Both his parents were scientists, and his father was head of the Department of Biochemistry at the Maharaja Sayajirao University of Baroda. At the time of his birth, Ramakrishnan's father was away from India doing postdoctoral research with David E. Green at the University of Wisconsin–Madison in the US.
His mother obtained a PhD in psychology from McGill University in 1959. completing it in only 18 months, and was mentored by Donald O. Hebb. Lalita Ramakrishnan, his younger sister, is professor of immunology and infectious diseases at the Department of Medicine, University of Cambridge, and is a member of the National Academy of Sciences.
Ramakrishnan moved to Vadodara (previously also known as Baroda) in Gujarat at the age of three, where he had his schooling at Convent of Jesus and Mary, except for spending 1960–61 in Adelaide, Australia. Following his pre-science at the Maharaja Sayajirao University of Baroda, he did his undergraduate studies in the same university on a National Science Talent Scholarship, graduating with a Bachelor of Science degree in physics in 1971. At the time, the physics course at Baroda was new, and based in part on the Berkeley Physics Course and The Feynman Lectures on Physics.
Immediately after graduation he moved to the US, where he obtained his Doctor of Philosophy degree in physics from Ohio University in 1976 for research into the ferroelectric phase transition of potassium dihydrogen phosphate (KDP) supervised by Tomoyasu Tanaka. Then he spent two years studying biology as a graduate student at the University of California, San Diego while making a transition from theoretical physics to biology.
Career and research
Ramakrishnan began work on ribosomes as a postdoctoral fellow with Peter Moore at Yale University. After his post-doctoral fellowship, he initially could not find a faculty position even though he had applied to about 50 universities in the U.S.
He continued to work on ribosomes from 1983–95 as a staff scientist at Brookhaven National Laboratory. In 1995 he moved to the University of Utah as a Professor of Biochemistry, and in 1999, he moved to his current position at the Medical Research Council Laboratory of Molecular Biology in Cambridge, England, where he had also been a sabbatical visitor during 1991–92 on a Guggenheim Fellowship.
In 1999, Ramakrishnan's laboratory published a 5.5 angstrom resolution structure of the 30S subunit. The following year, his laboratory determined the complete molecular structure of the 30S subunit of the ribosome and its complexes with several antibiotics. This was followed by studies that provided structural insights into the mechanism that ensures the fidelity of protein biosynthesis. In 2007, his laboratory determined the atomic structure of the whole ribosome in complex with its tRNA and mRNA ligands. Since 2013, he has used cryo-EM to work primarily on eukaryotic and mitochondrial translation. Ramakrishnan is also known for his past work on histone and chromatin structure.
Ramakrishnan's term as president of the Royal Society was dominated by Brexit and, in his final year, the COVID-19 pandemic and its response. In an interview in July 2018, he said that Britain's decision to leave the European Union (Brexit) was hurting Britain's reputation as a good place to work in science, commenting "It's very hard for the science community to see any advantages in Brexit. They are pretty blunt about that." He saw advantages to both the UK and the EU for Britain to continue to be engaged in Galileo and Euratom, which, unlike the European Medicines Agency, are not EU agencies.
Ramakrishnan argued that a no deal Brexit would harm science. Ramakrishnan wrote, "A deal on science is in the best interests of Europe as a whole and should not be sacrificed as collateral damage over disagreements on other issues. If we are going to successfully tackle global problems like climate change, human disease and food security, we can't do so in isolation. There is no scenario where trashing our relationships with our closest scientific collaborators in the EU gets us closer to these goals."
Awards and honours
Ramakrishnan was elected a Member of the European Molecular Biology Organization (EMBO) in 2002, a Fellow of the Royal Society (FRS) in 2003, and a Member of the U.S. National Academy of Sciences in 2004. In 2007, Ramakrishnan was awarded the Louis-Jeantet Prize for Medicine and the Datta Lectureship and Medal of the Federation of European Biochemical Societies (FEBS). In 2008, he won the Heatley Medal of the British Biochemical Society. Since 2008, he is a Fellow of Trinity College, Cambridge and a foreign Fellow of the Indian National Science Academy. In 2010 he became a member of the German Academy of Sciences Leopoldina. He was elected an Honorary Fellow of the Academy of Medical Sciences in 2010, and has received honorary degrees from the Maharaja Sayajirao University of Baroda, University of Utah and University of Cambridge. He is also an Honorary Fellow of Somerville College, Oxford. In 2020 he was elected to the American Philosophical Society. Also in 2020, he became a board member of The British Library.
In 2009, Ramakrishnan was awarded the Nobel Prize in Chemistry along with Thomas A. Steitz and Ada Yonath. He received India's second highest civilian honor, the Padma Vibhushan, in 2010. Ramakrishnan was knighted in the 2012 New Year Honours for services to Molecular Biology, but does not generally use the title "Sir". In the same year, he was awarded the Sir Hans Krebs Medal by the FEBS. In 2014, he was awarded the XLVI Jiménez-Díaz Prize by the Fundación Conchita Rábago (Spain). In 2017, Ramakrishnan received the Golden Plate Award of the American Academy of Achievement. Ramakrishnan was included as one of 25 Greatest Global Living Indians by NDTV Channel, India on 14 December 2013. His certificate of election to the Royal Society reads:
Ramakrishnan is internationally recognised for determination of the atomic structure of the 30S ribosomal subunit. Earlier he mapped the arrangement of proteins in the 30S subunit by neutron diffraction and solved X-ray structures of individual components and their RNA complexes. Fundamental insights came from his crystallographic studies of the complete 30S subunit. The atomic model included over 1500 bases of RNA and 20 associated proteins. The RNA interactions representing the P-site tRNA and the mRNA binding site were identified and the likely modes of action of many clinically important antibiotics determined. His most recent work goes to the heart of the decoding mechanism showing the 30S subunit complexed with poly-U mRNA and the stem-loop of the cognate phenylalanine tRNA. Anti-codon recognition leaves the "wobble" base free to accommodate certain non-Watson/Crick basepairs, thus providing an atomic description of both codon:anti-codon recognition and "wobble". He has also made substantial contributions to understanding how chromatin is organised, particularly the structure of linker histones and their role in higher order folding.
Ramakrishnan married Vera Rosenberry, an author and illustrator of children's books, in 1975. His stepdaughter, Tanya Kapka, is a doctor in Oregon, and his son, Raman Ramakrishnan, is a cellist based in New York.
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- Cerf, Corinne; Lippens, Guy; Muyldermans, Serge; Segers, Alain; Ramakrishnan, V.; Wodak, Shoshana J.; Hallenga, Klaas; Wyns, Lode (1993). "Homo- and heteronuclear two-dimensional NMR". Biochemistry. 32 (42): 11345–11351. doi:10.1021/bi00093a011. PMID 8218199.
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- Venki Ramakrishnan Official website
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- Ramakrishnan, C. V.; Banerjee, B. N. (1951). "Mould Lipase: Effect of Addition of Vitamins and Sterol to the Cake Medium on the Growth and the Activity of the Lipolytic Mould". Nature. 168 (4282): 917–918. Bibcode:1951Natur.168..917R. doi:10.1038/168917a0. PMID 14899529. S2CID 4244697.
- Ramakrishnan, Rajalakshmi (1959). Comparative Effects of Successive and Simultaneous Presentation on Transfer in Verbal Learning (PhD thesis). McGill University. ProQuest 301865011.
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- Ramakrishnan, Venkatraman (1976). The Green function theory of the ferroelectric phase transition in KDP (PhD thesis). Ohio University. OCLC 3079828. ProQuest 302809453.
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- Fernández, Israel S.; Bai, Xiao-Chen; Hussain, Tanweer; Kelley, Ann C.; Lorsch, Jon R.; Ramakrishnan, V.; Scheres, Sjors H. W. (15 November 2013). "Molecular architecture of a eukaryotic translational initiation complex". Science. 342 (6160): 1240585. doi:10.1126/science.1240585. ISSN 1095-9203. PMC 3836175. PMID 24200810.
- Amunts, Alexey; Brown, Alan; Bai, Xiao-Chen; Llácer, Jose L.; Hussain, Tanweer; Emsley, Paul; Long, Fei; Murshudov, Garib; Scheres, Sjors H. W. (28 March 2014). "Structure of the yeast mitochondrial large ribosomal subunit". Science. 343 (6178): 1485–1489. Bibcode:2014Sci...343.1485A. doi:10.1126/science.1249410. ISSN 1095-9203. PMC 4046073. PMID 24675956.
- Venki Ramakrishnan publications indexed by Google Scholar
- Ramakrishnan, V.; Wimberly, Brian T.; Brodersen, Ditlev E.; Clemons, William M.; Morgan-Warren, Robert J.; Carter, Andrew P.; Vonrhein, Clemens; Hartsch, Thomas (2000). "Structure of the 30S ribosomal subunit". Nature. 407 (6802): 327–339. Bibcode:2000Natur.407..327W. doi:10.1038/35030006. PMID 11014182. S2CID 4419944.
- Ramakrishnan, V.; Carter, Andrew P.; Clemons, William M.; Brodersen, Ditlev E.; Morgan-Warren, Robert J.; Wimberly, Brian T. (2000). "Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics". Nature. 407 (6802): 340–348. Bibcode:2000Natur.407..340C. doi:10.1038/35030019. PMID 11014183. S2CID 4408938.
- Ramakrishnan, V.; Finch, J. T.; Graziano, V.; Lee, P. L.; Sweet, R. M. (1993). "Crystal structure of globular domain of histone H5 and its implications for nucleosome binding". Nature. 362 (6417): 219–223. Bibcode:1993Natur.362..219R. doi:10.1038/362219a0. PMID 8384699. S2CID 4301198.
- Selmer, M. (2006). "Structure of the 70S Ribosome Complexed with mRNA and tRNA". Science. 313 (5795): 1935–1942. Bibcode:2006Sci...313.1935S. doi:10.1126/science.1131127. PMID 16959973. S2CID 9737925.
- Ogle, J. M. (2001). "Recognition of Cognate Transfer RNA by the 30S Ribosomal Subunit". Science. 292 (5518): 897–902. Bibcode:2001Sci...292..897O. doi:10.1126/science.1060612. PMID 11340196. S2CID 10743202.
- Ramakrishnan, V. (2002). "Ribosome Structure and the Mechanism of Translation". Cell. 108 (4): 557–572. doi:10.1016/s0092-8674(02)00619-0. PMID 11909526. S2CID 2078757.
- Brodersen, Ditlev E.; Clemons, William M.; Carter, Andrew P.; Morgan-Warren, Robert J.; Wimberly, Brian T.; Ramakrishnan, V. (2000). "The Structural Basis for the Action of the Antibiotics Tetracycline, Pactamycin, and Hygromycin B on the 30S Ribosomal Subunit". Cell. 103 (7): 1143–1154. doi:10.1016/s0092-8674(00)00216-6. PMID 11163189. S2CID 7763859.
- Ogle, James M.; Murphy, Frank V.; Tarry, Michael J.; Ramakrishnan, V. (2002). "Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form". Cell. 111 (5): 721–732. doi:10.1016/s0092-8674(02)01086-3. PMID 12464183. S2CID 10784644.
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