|Native name||வெங்கட்ராமன் ராமகிருஷ்ணன்|
|Born||1952 (age 62–63)
Chidambaram, Tamil Nadu, India
|Other names||Venki Ramakrishnan|
|Citizenship||United States and United Kingdom|
|Thesis||The Green Function Theory of the Ferroelectric Phase Transition in Potassium Dihyrogen-Phosphate (1976)|
Venkatraman Ramakrishnan (born 1952) is an Indian-born American and British structural biologist, best known for his pioneering work on the ribosome. He currently works at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) in Cambridge, England Upon the retirement of Paul Nurse, Ramakrishnan will take up the post of President of the Royal Society on November 30 2015.  In 2009 he shared the Nobel Prize in Chemistry with Thomas A. Steitz and Ada E. Yonath, "for studies of the structure and function of the ribosome".
Education and early life
Ramakrishnan was born in Chidambaram in Cuddalore district of Tamil Nadu, India to C. V. Ramakrishnan and R. Rajalakshmi. Both his parents were scientists and taught biochemistry at the Maharaja Sayajirao University in Baroda. He moved to Vadodara (previously also known as Baroda) in Gujarat at the age of three, where he had his schooling at Convent of Jesus and Mary, except for spending 1960–61 in Adelaide, Australia. Following his Pre-Science at the Maharaja Sayajirao University of Baroda, he did his undergraduate studies in the same university on a National Science Talent Scholarship, graduating with a BSc degree in Physics in 1971.
In a lecture in January 2010 at the Indian Institute of Science, he revealed that he failed to get admitted to any of the Indian Institutes of Technology or the Christian Medical College, Vellore, Tamil Nadu.
Immediately after graduation he moved to the U.S.A., where he obtained his PhD degree in Physics from Ohio University in 1976 on the Ferroelectric phase transition of Potassium Dihydrogen Phosphate (KDP) He then spent two years studying biology as a graduate student at the University of California, San Diego while making a transition from theoretical physics to biology.
Ramakrishnan began work on ribosomes as a postdoctoral fellow with Peter Moore at Yale University. After his post-doctoral fellowship, he initially could not find a faculty position even though he had applied to about 50 universities in the U.S.
He continued to work on ribosomes from 1983-95 as a staff scientist at Brookhaven National Laboratory. In 1995 he moved to the University of Utah as a Professor of Biochemistry, and in 1999, he moved to his current position at the Medical Research Council Laboratory of Molecular Biology in Cambridge, England, where he had also been a sabbatical visitor during 1991-92.
In 2005, Ramakrishnan's laboratory published a 5.5 Angstrom resolution structure of the 30S subunit. The following year, his laboratory determined the complete molecular structure of the 30S subunit of the ribosome and its complexes with several antibiotics. This was followed by studies that provided structural insights into the mechanism that ensures the fidelity of protein biosynthesis. More recently in 2007 his laboratory has determined the atomic structure of the whole ribosome in complex with its tRNA and mRNA ligands. Ramakrishnan is also known for his past work on histone and chromatin structure.
Awards and Honours
Ramakrishnan was elected a Member of the European Molecular Biology Organization in 2002 and a Fellow of the Royal Society (FRS) in 2003. He was elected a Member of the U.S. National Academy of Sciences in 2004. In 2007, Ramakrishnan was awarded the Louis-Jeantet Prize for Medicine and the Datta Lectureship and Medal of the Federation of European Biochemical Societies (FEBS). In 2008, he won the Heatley Medal of the British Biochemical Society. Since 2008, he is a Fellow of Trinity College, Cambridge and a foreign Fellow of the Indian National Science Academy. In 2009, Ramakrishnan was awarded the Nobel Prize in Chemistry along with Thomas A. Steitz and Ada Yonath. He received India's second highest civilian honor, the Padma Vibhushan, in 2010. Ramakrishnan was knighted in the 2012 New Year Honours for services to Molecular Biology, but does not generally use the title. In the same year, he was awarded the Sir Hans Krebs Medal by the FEBS. In 2013, he won the Spanish Jiménez-Diáz Prize. Ramakrishnan was included as one of 25 Greatest Global Living Indians by NDTV Channel, India on 14 December 2013. His nomination for the Royal Society reads:
|“||Ramakrishnan is internationally recognised for determination of the atomic structure of the 30S ribosomal subunit. Earlier he mapped the arrangement of proteins in the 30S subunit by neutron diffraction and solved X-ray structures of individual components and their RNA complexes. Fundamental insights came from his crystallographic studies of the complete 30S subunit. The atomic model included over 1500 bases of RNA and 20 associated proteins. The RNA interactions representing the P-site tRNA and the mRNA binding site were identified and the likely modes of action of many clinically important antibiotics determined. His most recent work goes to the heart of the decoding mechanism showing the 30S subunit complexed with poly-U mRNA and the stem-loop of the cognate phenylalanine tRNA. Anti-codon recognition leaves the "wobble" base free to accommodate certain non-Watson/Crick basepairs, thus providing an atomic description of both codon:anti-codon recognition and "wobble". He has also made substantial contributions to understanding how chromatin is organised, particularly the structure of linker histones and their role in higher order folding.||”|
Ramakrishnan is married to Vera Rosenberry, an author and illustrator of children's books. His stepdaughter Tanya Kapka is a doctor in Oregon, and his son Raman Ramakrishnan is a cellist based in New York.
- Cerf, Corinne; Lippens, Guy; Muyldermans, Serge; Segers, Alain; Ramakrishnan, V.; Wodak, Shoshana J.; Hallenga, Klaas; Wyns, Lode (1993). "Homo- and heteronuclear two-dimensional NMR". Biochemistry (American Chemical Society) 32 (42): 11345–11351. doi:10.1021/bi00093a011. Retrieved 2015-06-17.
- RAMAKRISHNAN, Sir Venkatraman. Who's Who 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
- "Venkatraman Ramakrishnan: Certificate of Election EC/2003/31". London: The Royal Society. 2003. Archived from the original on 2015-06-18.
- Nair, P. (2011). "Profile of Venkatraman Ramakrishnan". Proceedings of the National Academy of Sciences 108 (38): 15676–15678. doi:10.1073/pnas.1113044108. PMC 3179092. PMID 21914843.
- Peplow, M. (2015). "Structural biologist named president of UK Royal Society". Nature. doi:10.1038/nature.2015.17153.
- "2009 Chemistry Nobel Laureates". Nobel Foundation. 2009. Retrieved 2009-10-14.
- Rodnina, Marina V.; Wintermeyer, Wolfgang (2010). "The ribosome goes Nobel". Trends in Biochemical Sciences (Elsevier BV) 35 (1): 1–5. doi:10.1016/j.tibs.2009.11.003. Retrieved 2015-06-17.
- "Venkatraman_Ramakrishnan". University of Cambridge. Archived from the original on 2015-04-19.
- Biography and Bibliographic Resources, from the Office of Scientific and Technical Information, United States Department of Energy
- Venkatraman Ramakrishnan Audio Interview Official Nobel Foundation website telephone interview
- "Common root: Tamil Nadu gets its third laureate". Times of India. TNN. 8 October 2009.
- "Nobel laureate Venkat Ramakrishnan failed IIT, medical entrance tests". The Times Of India. 2010-01-05.
- Ramakrishnan, Venkatraman (1976). The Green function theory of the ferroelectric phase transition in KDP (PhD thesis). Ohio University. OCLC 3079828.
- Ramakrishnan, Venkatraman; Tanaka, Tomoyasu (1977). "Green's-function theory of the ferroelectric phase transition in potassium dihydrogen phosphate (KDP)". Physical Review B (American Physical Society) 16 (1): 422–426. doi:10.1103/physrevb.16.422. Retrieved 2015-06-17.
- "Venkatraman Ramakrishnan: A profile". Times of India. 2009-10-07. Retrieved 2009-10-07.
- "FACTBOX: Nobel chemistry prize – Who are the winners?". Reuters. 2009-10-07. Retrieved 2009-10-07.
- "Profile: Dr Venkatraman Ramakrishnan". Indian Express. 7 October 2009. Retrieved 2009-10-07.
- Venkatraman Ramakrishnan's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
- PMID 11014182 (PubMed)
- PMID 11014183 (PubMed)
- PMID 8384699 (PubMed)
- PMID 11340196 (PubMed)
- PMID 16959973 (PubMed)
- PMID 11163189 (PubMed)
- PMID 11909526 (PubMed)
- PMID 12464183 (PubMed)
- "All Nobel Laureates in Chemistry". Nobel Foundation. Retrieved 2009-10-07.
- "This Year's Padma Awards announced" (Press release). Ministry of Home Affairs. 25 January 2010. Retrieved 25 January 2010.
- The London Gazette: . 31 December 2011.
- Amit Roy (17 Oct 2009). "‘Venki’ makes light of India link – Winner says not to treat science like cricket; league of misses grows". The Telegraph (Kolkata). Retrieved 2009-10-17.
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