Ventrolateral prefrontal cortex
|Ventrolateral Prefrontal Cortex|
|Latin||Cortex praefrontalis ventrolateralis|
|Anatomical terms of neuroanatomy|
Ventrolateral prefrontal cortex (VLPFC), part of the prefrontal cortex, is located on the inferior frontal gyrus, is bounded superiorly by the inferior frontal sulcus and inferiorly by the lateral sulcus, being attributed to the anatomical structures of Brodmann's area (BA) 47, 45 and 44 (considered the subregions of the VLPFC – the anterior, mid and posterior subregions). Specific functional distinctions have been presented between these three subregions. There are also specific functional differences in activity in the right and left VLPFC. Neuroimaging studies employing various cognitive tasks have shown that right VLPFC region is a critical substrate of control. At present, two prominent theories feature right VLPFC as a key functional region. From one perspective, right VLPFC is thought to play a critical role in motor inhibition, where control is engaged to stop or override motor responses. Alternatively, Corbetta and Shulman have advanced the hypothesis that there are two distinct fronto-parietal networks involved in spatial attention, with right VLPFC being a component of a right-lateralized ventral attention network that governs reflexive reorienting. From this perspective, right lateral PFC, along with a region spanning right temporoparietal junction (TPJ) and the inferior parietal lobule, are engaged when abrupt onsets occur in the environment, suggesting that these regions are involved in re-orienting attention to perceptual events that occur outside the current focus of attention. Also, VLPFC is the end point of the Ventral Pathway (Stream) that brings information about the stimuli's characteristics.
The whole right VLPFC is active during motor inhibition having a critical role, meaning when the person is walking, and suddenly stops – the VLPFC activates to stop or to override the motor activity in the cortex. The right posterior VLPFC (BA 44) is active during the updating of action plans. The right middle VLPFC (BA 45) is responding to decision uncertainty. (presumably in right-handed individuals)
- Attention versus memory in prefrontal cortex
- Attentional shift
- Cognitive control
- Dorsolateral prefrontal cortex
- Mesocortical pathway
- Wisconsin Card Sorting Test
- Working memory
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- Corbetta, M; Shulman, GL (Mar 2002). "Control of goal-directed and stimulus-driven attention in the brain.". Nat Rev Neurosci. 3 (3): 201–15. PMID 11994752. doi:10.1038/nrn755.
- Corbetta, M; Patel, G; Shulman, GL (May 2008). "The reorienting system of the human brain: from environment to theory of mind.". Neuron. 58 (3): 306–24. PMC . PMID 18466742. doi:10.1016/j.neuron.2008.04.017.
- Lee, T. G.; Blumenfeld, R. S.; d'Esposito, M. (2013). "Disruption of Dorsolateral but Not Ventrolateral Prefrontal Cortex Improves Unconscious Perceptual Memories". Journal of Neuroscience. 33 (32): 13233–7. PMC . PMID 23926275. doi:10.1523/JNEUROSCI.5652-12.2013.