Vesicular acetylcholine transporter

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SLC18A3
Identifiers
AliasesSLC18A3, VACHT, solute carrier family 18 member A3, CMS21
External IDsMGI: 1101061 HomoloGene: 11022 GeneCards: SLC18A3
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for SLC18A3
Genomic location for SLC18A3
Band10q11.23Start49,610,301 bp[1]
End49,612,720 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003055

NM_021712

RefSeq (protein)

NP_003046

NP_068358

Location (UCSC)Chr 10: 49.61 – 49.61 MbChr 14: 32.46 – 32.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The Vesicular acetylcholine transporter (VAChT) is a neurotransmitter transporter which is responsible for loading acetylcholine (ACh) into secretory organelles in neurons making acetylcholine available for secretion.[5][6] It is encoded by Solute carrier family 18, member 3 (SLC18A3) gene. VAChT is able to transport ACh into vesicles by relying on an exchange between protons that were previously pumped into the vesicle diffusing out. ACh molecules are then carried into the vesicle by the action of exiting protons.[7] Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene.

VAChT uptake inhibitors[edit]

Radiolabeled compounds[edit]

PET imaging of the VAChT may provide insights into early diagnosis of Alzheimer's disease.

  • (−)-trans-2-Hydroxy-3-(4-(4-[18F]fluorobenzoyl)piperidino)tetralin; racemate: Ki = 2.70 nM for VAChT, 191 nM for σ1, and 251 nM for σ2[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187714 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000100241 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Erickson JD, Varoqui H (Dec 2000). "Molecular analysis of vesicular amine transporter function and targeting to secretory organelles". FASEB Journal. 14 (15): 2450–8. doi:10.1096/fj.00-0206rev. PMID 11099462. 
  6. ^ Weihe E, Tao-Cheng JH, Schäfer MK, Erickson JD, Eiden LE (Apr 1996). "Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles". Proceedings of the National Academy of Sciences of the United States of America. 93 (8): 3547–52. doi:10.1073/pnas.93.8.3547. PMC 39647Freely accessible. PMID 8622973. 
  7. ^ Waymire, Jack. "Storage of ACh". University of Texas Medical Center. 
  8. ^ Tu Z, Efange SM, Xu J, Li S, Jones LA, Parsons SM, Mach RH (Mar 2009). "Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter". Journal of Medicinal Chemistry. 52 (5): 1358–69. doi:10.1021/jm8012344. PMC 2765529Freely accessible. PMID 19203271. 

Further reading[edit]

External links[edit]