Vesiculobullous disease

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Vesiculobullous disease
Vesicles and Bulla.svg
Diagram showing cross section of vesicles (left) and bullae (right) on skin.
SpecialtyDermatology Edit this on Wikidata

A vesiculobullous disease is a type of mucocutaneous disease characterized by vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, and they are distinguished by size (vesicles being less than 5–10 mm and bulla being larger than 5–10 mm, depending upon which definition is used). In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous[1] is sometimes used. Examples of vesiculobullous diseases include:

Some features are as follows:

Name Acantholysis? Ig
epidermolysis bullosa yes mostly IgG
bullous pemphigoid no mostly IgG
dermatitis herpetiformis no IgA


  1. ^ Magro, C. M.; Roberts-Barnes, J.; Crowson, A. N. (2012). "Direct Immunofluorescence Testing in the Diagnosis of Immunobullous Disease, Collagen Vascular Disease, and Vascular Injury Syndromes". Dermatologic Clinics. 30 (4): 763–798, viii. doi:10.1016/j.det.2012.06.008. PMID 23021058.
  2. ^ Williams DM (December 1989). "Vesiculobullous mucocutaneous disease: pemphigus vulgaris". J. Oral Pathol. Med. 18 (10): 544–53. PMID 2695619.
  3. ^ Rao R, Prabhu SS, Sripathi H, Gupta S (2008). "Vesiculobullous lesions in lipoid proteinosis: a case report". Dermatol. Online J. 14 (7): 16. PMID 18718200.

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