Vestigial-like family member 3

VGLL3
Identifiers
Aliases	VGLL3, VGL-3, VGL3, Vestigial-like family member 3, vestigial like family member 3
External IDs	OMIM: 609980 MGI: 1920819 HomoloGene: 53442 GeneCards: VGLL3
Gene location (Human) Chr. Chromosome 3 (human) Band 3p12.1 Start 86,876,388 bp End 86,991,149 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C1.3 Start 65,612,143 bp End 65,663,254 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung saphenous vein placenta parietal pleura superficial temporal artery Achilles tendon pericardium germinal epithelium stromal cell of endometrium visceral pleura Top expressed in sciatic nerve calvaria belly cord ascending aorta skin of abdomen skin of back aortic valve uterus trigeminal ganglion fossa More reference expression data BioGPS n/a
Gene ontology Molecular function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 389136 73569 Ensembl ENSG00000206538 ENSMUSG00000091243 UniProt A8MV65 P85442 RefSeq (mRNA) NM_016206 NM_001320493 NM_001320494 NM_028572 NM_001368760 NM_001368761 RefSeq (protein) NP_001307422 NP_001307423 NP_057290 NP_082848 NP_001355689 NP_001355690 Location (UCSC) Chr 3: 86.88 – 86.99 Mb Chr 16: 65.61 – 65.66 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Vestigial-like family member 3 is a protein that in humans is encoded by the VGLL3 gene.

See also

• Vestigial like family member 4

Further reading

• Tao S, Wang Z, Feng J, Hsu FC, Jin G, Kim ST, Zhang Z, Gronberg H, Zheng LS, Isaacs WB, Xu J, Sun J (March 2012). "A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants". Carcinogenesis. 33 (3): 598–603. doi:10.1093/carcin/bgr316. PMC 3291863. PMID 22219177.
• Gambaro K, Quinn MC, Wojnarowicz PM, Arcand SL, de Ladurantaye M, Barrès V, Ripeau JS, Killary AM, Davis EC, Lavoie J, Provencher DM, Mes-Masson AM, Chevrette M, Tonin PN (June 2013). "VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer". Molecular Oncology. 7 (3): 513–30. doi:10.1016/j.molonc.2012.12.006. PMC 5528482. PMID 23415753.
• Zhou W, Chen H, Zhang L (March 2009). "The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor" (PDF). BMB Reports. 42 (3): 154–9. doi:10.5483/bmbrep.2009.42.3.154. PMID 19336002.
• Halperin DS, Pan C, Lusis AJ, Tontonoz P (February 2013). "Vestigial-like 3 is an inhibitor of adipocyte differentiation". Journal of Lipid Research. 54 (2): 473–81. doi:10.1194/jlr.M032755. PMC 3541706. PMID 23152581.
• Hélias-Rodzewicz Z, Pérot G, Chibon F, Ferreira C, Lagarde P, Terrier P, Coindre JM, Aurias A (December 2010). "YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas". Genes, Chromosomes & Cancer. 49 (12): 1161–71. doi:10.1002/gcc.20825. PMID 20842732. S2CID 205828045.
• Wang L, Lu W, Chen YG, Zhou XM, Gu JR (December 1999). "Comparison of gene expression between normal colon mucosa and colon carcinoma by means of messenger RNA differential display". World Journal of Gastroenterology. 5 (6): 533–534. doi:10.3748/wjg.v5.i6.533. PMC 4688801. PMID 11819507.
• Maeda T, Chapman DL, Stewart AF (December 2002). "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation". The Journal of Biological Chemistry. 277 (50): 48889–98. doi:10.1074/jbc.M206858200. PMID 12376544.