Vijendra K. Singh

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Vijendra Kumar Singh
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Institutions Utah State University, University of Michigan College of Pharmacy
Alma mater Lucknow University, University of British Columbia
Thesis Studies on brain nuclear RNA polymerase and chromatin transcription (1972)
Notable awards O. Spurgeon English Humanitarian Award[1]

Vijendra Kumar Singh is a neuroimmunologist who formerly held a post at Utah State University, prior to which he was a professor at the University of Michigan. While affiliated with both institutions, he conducted some controversial autism-related research focusing on the potential role of immune system disorders in the etiology of autism. For example, he has testified before a US congressional committee that, in his view, "three quarters of autistic children suffer from an autoimmune disease."

Career[edit]

Singh originally worked at a children's hospital in Vancouver, and is the author of over 100 scientific publications. The original focus of his research was neurochemistry, but his interest in the role of the immune system in neurodevelopmental disorders was sparked after reading an article on the mind-body relationship, which proposed a biological mechanism to explain the signaling taking place both in the brain and in the immune system.[2] In 2004, Singh gave a talk before the Institute of Medicine in which he recommended testing for immune disorders before vaccinating children, a proposal which was declined, according to Singh, because of its high cost (almost $100 per child).[3] As of 2009 he was working at the Brain State International Research Center in Scottsdale, Arizona.[4] He is currently affiliated with Neuro Immune Biotechnology Solutions, as the organization's scientific director. He is also a member of the Autism Autoimmunity Project.[5]

Research[edit]

In 1998, Singh, while affiliated with the University of Michigan, coauthored a paper in Clinical Immunology and Immunopathology reporting the presence of antibodies to myelin basic protein in autistic children and arguing that a virally triggered autoimmune response might cause autism.[6] In 2002, Singh et al. published a paper in the Journal of Biomedical Science in which it was reported that 75 of 125 autistic children had an abnormal measles antibody, whereas none of the non-autistic children did. In addition, the study concluded that "...an inappropriate antibody response to MMR, specifically the measles component thereof, might be related to pathogenesis of autism."[7] The results were reported on by the Daily Telegraph, which noted that the study did not prove that the MMR vaccine caused autism; rather, "autism may be responsible for the unusual response to the MMR antibodies."[8]

Singh's findings on autism have been criticized by other scientists as flawed, unreproducible, or dubious. Mary Ramsay of the Health Protection Agency wrote that the evidence for the "specific" MMR-type antibody Singh claims to have detected was "not credible."[9] Paul Offit wrote in Autism's False Prophets that "...a closer look at Singh's science revealed two critical flaws: children with autism didn't have evidence of nerve cell damage, and, according to measles experts, the test that Singh had used to detect measles antibodies didn't actually detect them."[10] A 2006 review of literature on vaccines and autism found that Singh's results "have been called into question due to issues of cross-contamination, as well as the use of unsubstantiated and un-validated biochemical techniques", citing a report by the World Health Organization,[11] and a number of other studies have failed to find a difference in immune response to the measles virus between autistic and neurotypical children.[12][13][14][15] Peter Lachmann, the president of the Academy of Medical Sciences, United Kingdom, stated: "Singh's work in these papers is not particularly reproducible or good... There are many diseases which show raised antibodies to measles, for example chronic active hepatitis or multiple sclerosis, yet there is nothing to associate these with MMR. There is no persuasive evidence that autism is caused by autoimmunity."

Testimony[edit]

In 2000, Singh testified before the Committee on Government Reform, led by Dan Burton, regarding the potential role of autoimmunity as a cause of autism. Part of his testimony centered on his findings of brain autoantibodies in autistic children.[16]

Alternative autism therapies[edit]

Singh endorses the treatment of autism with nutraceuticals, transfer factors and glyconutrients.[17] In addition, Singh "recommends treating autistic children with a range of immunological treatments, including steroids, intravenous immunoglobulin, plasmapheresis, and sphingomyelin."[9]

Selected publications[edit]

  • Singh, V. K.; Lin SX; Newell E; Nelson C. (2002). "Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism". J Biomed Sci. 2002 Jul-Aug;9(4):359-64 PMID 12145534 DOI 65007
  • Singh, V. K.; Warren, R. P.; Odell, J. D.; Warren, W. L.; Cole, P. (1993). "Antibodies to Myelin Basic Protein in Children with Autistic Behavior". Brain, Behavior, and Immunity. 7: 97. doi:10.1006/brbi.1993.1010. 
  • Singh, V. K.; Warren, R.; Averett, R.; Ghaziuddin, M. (1997). "Circulating autoantibodies to neuronal and glial filament proteins in autism". Pediatric Neurology. 17 (1): 88–90. PMID 9308986. doi:10.1016/S0887-8994(97)00045-3. 
  • Singh, V. K. (1996). "Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism". Journal of Neuroimmunology. 66 (1–2): 143–145. PMID 8964908. doi:10.1016/0165-5728(96)00014-8. 

References[edit]

  1. ^ "Utah State Researcher Receives Humanitarian Award". Utah State University. 5 November 2002. Retrieved 26 August 2013. 
  2. ^ "Autoimmunity and neurological disorders". ACN. 2007. Retrieved 25 August 2013. 
  3. ^ "Insights" (PDF). Utah State University College of Science. Fall 2005. p. 23. Retrieved 26 August 2013. 
  4. ^ Singh, V. K. (2009). "Phenotypic expression of autoimmune autistic disorder (AAD): A major subset of autism". Annals of Clinical Psychiatry. 21 (3): 148–161. PMID 19758536. 
  5. ^ "Vijendra Singh". Zoominfo. 31 July 2013. Retrieved 29 August 2013. 
  6. ^ Singh, V. K.; Lin, S. X.; Yang, V. C. (1998). "Serological Association of Measles Virus and Human Herpesvirus-6 with Brain Autoantibodies in Autism". Clinical Immunology and Immunopathology. 89 (1): 105–108. PMID 9756729. doi:10.1006/clin.1998.4588. 
  7. ^ Singh, V. K.; Lin, S. X.; Newell, E.; Nelson, C. (2002). "Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism". Journal of biomedical science. 9 (4): 359–364. PMID 12145534. doi:10.1007/BF02256592. 
  8. ^ Derbyshire, David (9 August 2002). "Study linking autism to MMR is published". The Daily Telegraph. Telegraph Media Group. Retrieved 25 August 2013. 
  9. ^ a b Fitzpatrick 2004, p. 90
  10. ^ Offit 2008, p. 45
  11. ^ Doja, A.; Roberts, W. (2006). "Immunizations and autism: a review of the literature". The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 33 (4): 341–346. PMID 17168158. doi:10.1017/s031716710000528x. 
  12. ^ Libbey, J. E.; Coon, H. H.; Kirkman, N. J.; Sweeten, T. L.; Miller, J. N.; Lainhart, J. E.; McMahon, W. M.; Fujinami, R. S. (2007). "Are there altered antibody responses to measles, mumps, or rubella viruses in autism?". Journal of Neurovirology. 13 (3): 252–259. PMID 17613715. doi:10.1080/13550280701278462. 
  13. ^ Baird, G.; Pickles, A.; Simonoff, E.; Charman, T.; Sullivan, P.; Chandler, S.; Loucas, T.; Meldrum, D.; Afzal, M.; Thomas, B.; Jin, L.; Brown, D. (2008). "Measles vaccination and antibody response in autism spectrum disorders". Archives of Disease in Childhood. 93 (10): 832–837. PMID 18252754. doi:10.1136/adc.2007.122937. 
  14. ^ d'Souza, Y.; Fombonne, E.; Ward, B. J. (2006). "No Evidence of Persisting Measles Virus in Peripheral Blood Mononuclear Cells from Children with Autism Spectrum Disorder". Pediatrics. 118 (4): 1664–1675. PMID 17015560. doi:10.1542/peds.2006-1262. 
  15. ^ Gentile, I.; Bravaccio, C.; Bonavolta, R.; Zappulo, E.; Scarica, S.; Riccio, M. P.; Settimi, A.; Portella, G.; Pascotto, A.; Borgia, G. (2013). "Response to measles-mumps-rubella vaccine in children with autism spectrum disorders". In vivo (Athens, Greece). 27 (3): 377–382. PMID 23606694. 
  16. ^ "AUTISM: PRESENT CHALLENGES, FUTURE NEEDS--WHY THE INCREASED RATES?". US Government Printing Office. 6 April 2000. Retrieved 28 August 2013. 
  17. ^ "USU Scientist offers hope for autistic children". Utah State Magazine. Summer 2006. Retrieved 25 August 2013. 

Bibliography[edit]