It was built in 1898 by the Italian architect Vitaliano Poselli. Of note is that the same architect designed the Mills of Allatini which were founded in 1890. At that time the region where the villa is located was called the district of "Countrysides" (des Campagnes) or "Towers", and was the easternmost limit of Thessaloniki.
In the first period of its use, the villa was the countryside residence of the Allatini family. After the emergence of the Young Turks movement, from 1909 until 1911 it was used as the residence of the sultan Abdul Hamid II, who after his unseating by the Young Turks lived there under house arrest. In 1926 it housed the Philosophical School for one year, the unique department of the newly founded University of Thessaloniki, while during the Greco-Italian War (1940-1941) it was used as a hospital.
From 1979 the Prefecture of Thessaloniki had its headquarters in Villa Allatini. In 2011 after the implementation of the Kallikratis Programm (law 3852/2010) the prefecture was abolished and replaced by regional self-governing bodies. Today Villa Allatini houses the Administration of the Region of Central Macedonia.
- Συλλογικό (2014). Thessaloniki: the city and its monuments. Thessaloniki: Μαλλιάρης Παιδεία. pp. 173–174.
- "Villa Allatini, today's building of the Administration of Region of Central Macedonia, Thessaloniki".
- "Villa Allatini".
- "Old Thessaloniki: The villa and the Allatini mills".
- "Greek Code for Municipalities and Communities".