Vincent Desiderio (born 1955) is an American realist painter. In 2005 he was on the teaching staff at the Pennsylvania Academy of the Fine Arts; he is a senior critic at the New York Academy of Art.
Desiderio was born in 1955, in Pennsylvania. He studied at Haverford College in Haverford, Pennsylvania; at the Pennsylvania Academy of the Fine Arts in Philadelphia; and at the Accademia di Belle Arti in Florence, Italy. In 1984 he joined the P.S. 1 Contemporary Art Center in New York City.
Vincent Desiderio is the father of four children, Sam, Oscar, Ian, and Lilly, from his first wife, Gale. He is also the stepfather of two children, Azure and Blaze, from his second wife, Roxanne. Desiderio's eldest son, Sam, was born with Hydrocephalus in 1986. He suffered a stroke as a young child, further disabling him and serving as the inspiration for much of Vincent's work thereafter.
Vincent's daughter Lilly is featured in his 2008 painting "Lilly in a round chair." 
- Larson, Kay (5 October 1987). "Shrinking History". New York Magazine.
- Edward Leffingwell (2005). Allegories of Painting. Art In America 93 (2): 98–103. (subscription required).
- Joe Coscarelli. The Artist Providing the Canvas for Kanye West's 'Famous' Video. The New York Times. June 29, 2016.
- "2005 National Medal of Arts". NEA. Retrieved 19 July 2011.