Vincent du Vigneaud
|Vincent du Vigneaud|
|Born||May 18, 1901
Chicago, Illinois, USA
|Died||December 11, 1978
Ithaca, New York, USA
|Alma mater||University of Illinois Urbana-Champaign University of Rochester|
|Doctoral advisor||John R. Murlin|
|Notable awards||Albert Lasker Award for Basic Medical Research (1948)
Nobel Prize for Chemistry (1955)
Willard Gibbs Award (1956)
Vincent du Vigneaud (May 18, 1901 – December 11, 1978) was an American biochemist. He won the 1955 Nobel Prize in Chemistry "for his work on biochemically important sulphur compounds, especially for the first synthesis of a polypeptide hormone," a reference to his work on the cyclic peptide oxytocin.
Du Vigneaud graduated from Schurz High School in 1918. He began studying chemistry at the University of Illinois at Urbana-Champaign. He was influenced by lectures of Carl Shipp Marvel. After receiving his M.S. in 1924 he joined DuPont.
He married Zella Zon Ford on June 12, 1924. Restarting his academic career in 1925, he joined the group of John R. Murlin at the University of Rochester for his Ph.D thesis. He graduated in 1927 with his work, The Sulfur in Insulin.
After post-doctoral position with John Jacob Abel at Johns Hopkins University Medical School (1927-1928), he traveled to Europe as National Research Council Fellow in 1928-1929, where he worked with Max Bergmann at the Kaiser Wilhelm Institute for Leather Research in Dresden, and with George Barger at the University of Edinburgh Medical School. He then returned to the University of Illinois as a professor.
He next went to George Washington University Medical School in Washington, D.C. in 1932 and to Cornell Medical College in New York City in 1938, where he stayed until his emeritation in 1967. Following that retirement, he held a position at Cornell University in Ithaca, New York.
In 1974 he suffered from a stroke which ended his academic career. One year after his wife's death in 1977, he died.
His career was characterized by an interest in sulfur, proteins, and especially, peptides. Even before his Nobel-Prize-winning work on elucidating and synthesizing oxytocin and vasopressin, he had established a reputation for work on insulin, biotin, transmethylation, and penicillin.
He also began a series of structure-activity relationships for oxytocin and vasopressin, perhaps the first for peptides. That work culminated in the publication of a book entitled, A Trail of Research in Sulphur Chemistry and Metabolism and Related Field.
- "The Nobel Prize in Chemistry 1955". Nobelprize.org. Nobel Media AB. Retrieved 17 November 2016.
- du Vigneaud, Vincent; Ressler, Charlotte; Swan, John M.; Roberts, Carleton W.; Katsoyannis, Panayotis G. (1954). "The Synthesis of Oxytocin". Journal of the American Chemical Society. 76 (12): 3115–3121. doi:10.1021/ja01641a004.
- Hofmann, Klaus. "Vincent du Vigneaud" (PDF). National Academy of Sciences. Retrieved 20 September 2012.
- Ragnarsson, Ulf (2007). "The Nobel trail of Vincent du Vigneaud". Journal of Peptide Science. 13 (7) (published Jul 2007). pp. 431–3. doi:10.1002/psc.864. PMID 17554806.