SR 276 begins at an intersection with SR 256 (Weyers Cave Road) in the village of Weyers Cave. The highway heads northeast as Keezletown Road, which also continues south from SR 256 as SR 750. SR 276 crosses the Augusta–Rockingham county line at the North River and continues as Cross Keys Road. Just north of the village of Cross Keys, the state highway intersects SR 253 (Port Republic Road). SR 276 reaches its northern terminus at US 33 (Spotswood Trail) just west of the village of Penn Laird and south of Keezletown at the southern end of Massanutten Mountain.