Vitamin D-dependent calcium-binding protein

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Vitamin D-dependent calcium binding proteins were discovered in the cytosolic fractions of chicken intestine, and later in mammalian intestine and kidney, by workers including Robert Wasserman of Cornell University.[1][2]

They bound calcium in the micromolar range and were greatly reduced in vitamin D-deficient animals. Expression could be induced by treating these animals with vitamin D metabolites such as calcitriol.

They were found to exist in two distinct sizes with a molecular weight of approximately 9 kDa and 28 kDa. They were renamed calbindin. Calbindin-D9k (S100G) is found in mammalian intestine and calbindin-D28k is in avian intestine and in mammalian kidney and other tissues.

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  1. ^ Wasserman, RH; Taylor, AN (1966). "Vitamin D3-induced calcium-binding protein in chick intestinal mucosa.". Science. 152 (3723): 791–3. PMID 17797460. doi:10.1126/science.152.3723.791. 
  2. ^ Wasserman, RH; Corradino, RA; Taylor, AN (1969). "Binding proteins from animals with possible transport function.". The Journal of General Physiology. 54 (1): 114–37. PMC 2225897Freely accessible. PMID 19873640. doi:10.1085/jgp.54.1.114. 

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