Vitamin D and Omega-3 Trial

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Vitamin D and Omega-3 Trial (VITAL) (VITamin D and OmegA-3 TriaL) is a 5 year trial to run from 2010 to determine the benefits of vitamin D and Omega-3 supplements on elderly Americans.[1] [2]

It aims to enroll 20,000 participants (women 55 or over, men 50 or over)[3][4] who will be randomized to one of four groups:[2]

  • daily vitamin D (2000 IU) and fish oil (1 g);
  • daily vitamin D and fish-oil placebo;
  • daily vitamin-D placebo and fish oil;
  • daily vitamin-D placebo and fish-oil placebo.

Participants will answer annual questionnaires[2] to determine effects on risk of cancer, heart disease, stroke, osteoporosis, diabetes, memory loss and depression.[citation needed]