|Trade names||Revia, Vivitrol, other|
|By mouth, intramuscular|
|Biological half-life||4 h (naltrexone),
13 h (6β-naltrexol)
|Chemical and physical data|
|Molar mass||341.401 g/mol|
|3D model (JSmol)|
|Melting point||169 °C (336 °F)|
|(what is this?)|
Naltrexone is marketed under the trade name Revia and Vivitrol. In the United States as of 2016, naltrexone tablets cost about US$0.91 per day. The extended-release injections cost about $1,248.50 per month ($41.62 per day). Naltrexone is also used in formulation with bupropion (bupropion/naltrexone) to treat obesity in the United States.
- 1 Medical uses
- 2 Adverse effects
- 3 Contraindications
- 4 Pharmacogenetics
- 5 Mechanism of action
- 6 Structure and pharmacokinetics
- 7 Formulations
- 8 Similar medication
- 9 Controversies
- 10 Research
- 11 See also
- 12 References
- 13 External links
The main use of naltrexone is for the treatment of alcoholism. Naltrexone has been shown to decrease the amount and frequency of drinking. It does not appear to change the percentage of people drinking. Its overall benefit has been described as "modest".
The Sinclair method is a method of using opiate antagonists such as naltrexone to treat alcoholism. The patient takes the medication about an hour (and only then) before drinking to avoid side effects that arise from chronic use. The opioid antagonist blocks the positive reinforcement effects of alcohol and allows the person to stop or reduce drinking.
Naltrexone helps patients overcome opioid addiction by blocking the effects of opioid drugs. It has little effect on opioid cravings. Naltrexone has in general been better studied for alcoholism than for opioids. It is more frequently used for alcoholism, despite its original approval by the FDA in 1984 for opioid addiction.
A 2011 review of studies suggested that naltrexone, when taken by mouth, was not superior to placebo or to no medication, nor was it superior to benzodiazepine or buprenorphine. Because of the poor quality of the reviewed studies, the authors found insufficient evidence to support naltrexone therapy when taken by mouth for an opioid use disorder. While some patients do well with the oral formulation, it must be taken daily, and a patient whose cravings become overwhelming can obtain opioid intoxication simply by skipping a dose. Due to this issue, the usefulness of oral naltrexone in opioid use disorders is limited by the low retention in treatment. Oral naltrexone remains an ideal treatment only for a small part of the opioid-addicted population, usually those with a stable social situation and motivation. With additional contingency management support, naltrexone is effective in a broader population.
Extended-release depot injections of naltrexone, administered once per month, have proven somewhat effective in treating opioid abuse, an approach that avoids the compliance issue that arises with oral formulations.
It is not useful for quitting smoking.
The most common side effects reported with naltrexone are gastrointestinal complaints such as diarrhea and abdominal cramping. These adverse effects are analogous to the symptoms of opioid withdrawal, as the mu receptor blockade will increase GI motility.
Naltrexone has been reported to cause liver damage (when given at doses higher than recommended). It carries an FDA boxed warning for this rare side effect. Due to these reports, some physicians may check liver function tests prior to starting naltrexone, and periodically thereafter. Concerns for liver toxicity initially arose from a study of non-addicted obese patients receiving 300 mg of naltrexone. Subsequent studies have suggested limited toxicity in other patient populations.
Naltrexone should not be started until several (typically 7-10) days of abstinence from opioids has been achieved. This is due to the risk of acute opioid withdrawal if naltrexone is taken, as naltrexone will displace most opioids from their receptors. The time of abstinence may be shorter than 7 days, depending on the half-life of the specific opioid taken. Some physicians use a naloxone challenge to determine whether an individual has any opioids remaining. The challenge involves giving a test dose of naloxone and monitoring for opioid withdrawal. If withdrawal occurs, naltrexone should not be started.
Naltrexone should not be used by persons with acute hepatitis or liver failure, or those with recent opioid use (typically 7–10 days).
A naltrexone treatment study by Anton et al., released by the National Institutes of Health in February 2008 and published in the Archives of General Psychiatry, has shown that alcoholics having a certain variant of the opioid receptor gene (G polymorphism of SNP Rs1799971 in the gene OPRM1), known as Asp40, demonstrated strong response to naltrexone and were far more likely to experience success at cutting back or discontinuing their alcohol intake altogether, while for those lacking the gene variant, naltrexone appeared to be no different from placebo. The G allele of OPRM1 is most common in individuals of Asian descent, with 60% to 70% of people of Chinese, Japanese, and Indian ancestry having at least one copy, as opposed to 30% of Europeans and few Africans.
Because of the characteristics of the patient group in the US, the first study was done on white patients and the next without regard for ethnicity. Anton et al. found that patients of African descent did not have much success with naltrexone in treatment for alcohol dependence because of lacking the relevant gene.
As white patients with the gene had a five times greater rate of success in reducing drinking when given naltrexone than did patients without the gene, when used in a protocol of Medical Management (MM), Anton et al. concluded,
"Because almost 25% of the treatment-seeking population carries the Asp40 allele, genetic testing of individuals before naltrexone treatment might be worth the cost and effort, especially if structured behavioral treatment were not being considered." This would enable treatment to be targeted by genetics to patients for whom it would be most effective. They noted, "Naltrexone is relatively easy to administer and free of serious adverse effects and, as we observed in the Asp40 carriers we studied, it appears to be highly effective."
Studies have found naltrexone to be more efficacious among certain white subjects, because of the genetic basis, than among black subjects, who generally do not carry the relevant gene variant. A 2009 study of naltrexone as an alcohol dependence treatment among African Americans failed to find any statistically significant differences between naltrexone and a placebo. Studies have suggested that carriers of the G allele may experience higher levels of craving and stronger "high" upon alcohol consumption, compared to carriers of the dominant allele, and naltrexone somewhat blunts these responses, leading to a reduction in alcohol use in some studies.
Mechanism of action
Naltrexone and its active metabolite 6β-naltrexol are competitive antagonists at the μ-opioid receptor (MOR), the κ-opioid receptor (KOR) to a lesser extent, and to a far lesser and possibly insignificant extent, at the δ-opioid receptor (DOR). The Ki affinity values of naltrexone at the MOR, KOR, and DOR have been reported as 0.0825 nM, 0.509 nM, and 8.02 nM, respectively, demonstrating a MOR/KOR binding ratio of 6.17 and a MOR/DOR binding ratio of 97.2.
The blockade of opioid receptors is the basis behind naltrexone's action in the management of opioid dependence—it reversibly blocks or attenuates the effects of opioids. Its mechanism of action in alcohol dependence is not fully understood, but as an opioid receptor antagonist is likely to be due to the modulation of the dopaminergic mesolimbic pathway (one of the primary centers for risk-reward analysis in the brain, and a tertiary "pleasure center") which is hypothesized to be a major center of the reward associated with addiction that all major drugs of abuse are believed to activate. Mechanism of action may be antagonism to endogenous opioids such as tetrahydropapaveroline, whose production is augmented in the presence of alcohol.
Structure and pharmacokinetics
Naltrexone can be described as a substituted oxymorphone – here the tertiary amine methyl-substituent is replaced with methylcyclopropane. Naltrexone is the N-cyclopropylmethyl derivative of oxymorphone.
Naltrexone is metabolized mainly to 6β-naltrexol by the liver enzyme dihydrodiol dehydrogenase. Other metabolites include 2-hydroxy-3-methoxy-6β-naltrexol and 2-hydroxy-3-methoxy-naltrexone. These are then further metabolized by conjugation with glucuronide.
Additionally, naltrexone implants that are surgically implanted are available, While these are manufactured in Australia, they are not authorized for use within Australia, but only for export. By 2009, naltrexone implants showed encouraging results.
The closely related medication, methylnaltrexone, is used to treat opioid-induced constipation but does not treat addiction as it does not cross the blood brain barrier. Nalmefene is similar to naltrexone and is used for the same purposes as naltrexone. Naltrexone should not be confused with naloxone, which is used in emergency cases of opioid overdose.
Krupitsky et al 2011 Alkermes-funded study
The FDA authorized use of injectable naltrexone (Vivitrol) for opioid addiction using a single study that was led by Evgeny Krupitsky MD at Bekhterev Research Psychoneurological Institute, St Petersburg State Pavlov Medical University, St Petersburg, Russia, a country where opioid agonists such as methadone and buprenorphine are not available. Krupitsky et al. undertook a "double-blind, placebo-controlled, randomised", 24-week trial running "from July 3, 2008 through October 5, 2009" with "250 patients with opioid dependence disorder" at "13 clinical sites in Russia" on the use of injectable naltrexone (XR-NTX) for opioid dependence. The study was funded by the Boston-based biotech Alkermes firm which produces and markets naltrexone in the United States. An 2011 article reported that this single trial of naltrexone was performed not by comparing it to the best available, evidence-based treatment (methadone or buprenorphine) but by comparing it with a placebo. In addition, the study failed to follow up on participants to document post-treatment overdose - a key measure for opioid substitution therapies. Furthermore, by 2011, Vivitrol cost about $1,100 a month, compared to $11 a month for generic naltrexone. A second 2011 article argued that these factors led to criticism of the study's design and ethics, and, by extension, of the FDA's approval of injectable naltrexone for opioid addiction based on this study.
Tom Price's remarks 2017
In May 2017, United States Secretary of Health and Human Services Tom Price, praised [vivitrol] as the future of opioid addiction treatment after visiting the company’s plant in Ohio. His remarks set off sharp criticism with almost 700 experts in the field of substance abuse submitting a letter to Price cautioning him about Vivitrol's "marketing tactics" and warning him that his comment "ignore widely accepted science". The experts pointed out that Vivitrol's competitors, buprenorphine and methadone, are "less expensive", "more widely used" and have been "rigorously studied".
Price had claimed that buprenorphine and methadone were "simply substitute"s for "illicit drugs" whereas according to the letter, "the substantial body of research evidence supporting these treatments is summarized in guidance from within your own agency, including the Substance Abuse and Mental Health Services Administration, the US Surgeon General, the National Institute on Drug Abuse, and the Centers for Disease Control and Prevention. To briefly summarize, buprenorphine and methadone have been demonstrated to be highly effective in managing the core symptoms of opioid use disorder, reducing the risk of relapse and fatal overdose, and encouraging long-term recovery."
According to a June 11, 2017 The New York Times article, Alkermes "has spent years coaxing, with a deft lobbying strategy that has targeted lawmakers and law enforcement officials. The company has spent millions of dollars on contributions to officials struggling to stem the epidemic of opioid abuse. It has also provided thousands of free doses to encourage the use of Vivitrol in jails and prisons, which have by default become major detox centers".
Naltrexone is sometimes used in the treatment of dissociative symptoms such as depersonalization and derealization. Some studies suggest it might help. Other small, preliminary studies have also shown benefit. It is thought that blockade of the KOR by naltrexone and naloxone is responsible for their effectiveness in ameliorating depersonalization and derealization. Since these drugs are less efficacious in blocking the KOR relative to the MOR, higher dose than typically used seem to be necessary.
"Low-dose naltrexone" (LDN) describes the "off-label" use of naltrexone at low doses for diseases not related to chemical dependency or intoxication, such as multiple sclerosis. More research needs to be done before it can be recommended for clinical use.
Although there are scientific studies showing its efficacy in some conditions such as fibromyalgia, other, more dramatic claims for its use in conditions like cancer and HIV have less scientific support. This treatment has received significant attention on the Internet, especially through websites run by organizations promoting its use.
A study done by The Chicago Stop Smoking Research Project at the University of Chicago found that naltrexone did not help to improve a subject's chance of attaining smoking cessation when compared to a placebo.
Some studies suggest that self-injurious behaviors present in persons with developmental disabilities (including autism) can sometimes be remedied with naltrexone. In these cases, it is believed that the self-injury is being done to release beta-endorphin, which binds to the same receptors as heroin and morphine. If the "rush" generated by self-injury is removed, the behavior may stop.
There are indications that naltrexone might be beneficial in the treatment of impulse control disorders such as kleptomania, compulsive gambling, or trichotillomania (compulsive hair pulling), but there is conflicting evidence of its effectiveness for gambling. A 2008 case study reported successful use of naltrexone in suppressing and treating an internet pornography addiction.
Countering adverse effects of interferon alpha
- One Little Pill (2014 film) - documentary about using naltrexone to treat alcohol use disorder
- Opioid antagonist § List of opioid antagonists
- C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1396–. ISBN 978-0-412-46630-4.
- "Naltrexone Monograph for Professionals - Drugs.com". Drugs.com. American Society of Health-System Pharmacists. Retrieved 9 November 2017.
- "NADAC as of 2016-10-12 | Data.Medicaid.gov". Centers for Medicare and Medicaid Services. Retrieved 12 October 2016.
- "Naltrexone". ATC/DDD Index. WHO Collaborating Centre for Drug Statistics Methodology. Retrieved 11 July 2016.
DDD ... 50 mg
- Rösner, S; Hackl-Herrwerth, A; Leucht, S; Vecchi, S; Srisurapanont, M; Soyka, M (8 December 2010). "Opioid antagonists for alcohol dependence". The Cochrane database of systematic reviews (12): CD001867. PMID 21154349.
- Donoghue, Kim; Elzerbi, Catherine; Saunders, Rob; Whittington, Craig; Pilling, Stephen; Drummond, Colin (2015). "The efficacy of acamprosate and naltrexone in the treatment of alcohol dependence, Europe versus the rest of the world: A meta-analysis". Addiction. 110 (6): 920–30. doi:10.1111/add.12875. PMID 25664494.
- c. Garbutt, James (2010). "Efficacy and Tolerability of Naltrexone in the Management of Alcohol Dependence". Current Pharmaceutical Design. 16 (19): 2091–7. doi:10.2174/138161210791516459. PMID 20482515.
- Maisel, Natalya C.; Blodgett, Janet C.; Wilbourne, Paula L.; Humphreys, Keith; Finney, John W. (October 17, 2012). "Meta-analysis of naltrexone and acamprosate for treating alcohol use disorders: When are these medications most helpful?". Addiction. 108 (2): 275–93. doi:10.1111/j.1360-0443.2012.04054.x. PMC . PMID 23075288.
- Anderson, Kenneth (Jul 28, 2013). "Drink Your Way Sober with Naltrexone". Psychology Today. Retrieved 18 July 2016.
- Sinclair, J. D. (2001). "Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism". Alcohol and Alcoholism. 36 (1): 2–10. doi:10.1093/alcalc/36.1.2. PMID 11139409.
- Dijkstra, Boukje A. G.; De Jong, Cor A. J.; Bluschke, Sarah M.; Krabbe, Paul F. M.; Van Der Staak, Cees P. F. (2007). "Does naltrexone affect craving in abstinent opioid-dependent patients?". Addiction Biology. 12 (2): 176–82. doi:10.1111/j.1369-1600.2007.00067.x. PMID 17508990.
- Galanter, Marc; Kleber, Herbert. The American Psychiatric Publishing Textbook of Substance Abuse Treatment, 4th Edition. ISBN 1585622761[page needed]
- Minozzi, Silvia; Amato, Laura; Vecchi, Simona; Davoli, Marina; Kirchmayer, Ursula; Verster, Annette (2011). "Oral naltrexone maintenance treatment for opioid dependence". Cochrane Database of Systematic Reviews (4): CD001333. doi:10.1002/14651858.CD001333.pub4. PMID 21491383.
- Johansson, Björn Axel; Berglund, Mats; Lindgren, Anna (2006). "Efficacy of maintenance treatment with naltrexone for opioid dependence: A meta-analytical review". Addiction. 101 (4): 491–503. doi:10.1111/j.1360-0443.2006.01369.x. PMID 16548929.
- Comer, Sandra D.; Sullivan, Maria A.; Yu, Elmer; Rothenberg, Jami L.; Kleber, Herbert D.; Kampman, Kyle; Dackis, Charles; o'Brien, Charles P. (2006). "Injectable, Sustained-Release Naltrexone for the Treatment of Opioid Dependence". Archives of General Psychiatry. 63 (2): 210–8. doi:10.1001/archpsyc.63.2.210. PMC . PMID 16461865.
- David, Sean P.; Lancaster, Tim; Stead, Lindsay F.; Evins, A. Eden; Prochaska, Judith J. (6 June 2013). "Opioid antagonists for smoking cessation". The Cochrane Database of Systematic Reviews (6): CD003086. doi:10.1002/14651858.CD003086.pub3. ISSN 1469-493X. PMC . PMID 23744347.
- Pfohl, David N.; Allen, John I.; Atkinson, Richard L.; Knopman, David S.; Malcolm, Robert J.; Mitchell, James E.; Morley, John E. (1986). "Naltrexone hydrochloride (Trexan): A review of serum transaminase elevations at high dosage". NIDA research monograph. 67: 66–72. PMID 3092099.
- Anton, Raymond F.; Oroszi, Gabor; o'Malley, Stephanie; Couper, David; Swift, Robert; Pettinati, Helen; Goldman, David (2008). "An Evaluation of μ-Opioid Receptor (OPRM1) as a Predictor of Naltrexone Response in the Treatment of Alcohol Dependence". Archives of General Psychiatry. 65 (2): 135–44. doi:10.1001/archpsyc.65.2.135. PMC . PMID 18250251.
- "Rs1799971 (SNPedia)".
- Kranzler, Henry R.; Kirk, Jeffrey (2001). "Efficacy of Naltrexone and Acamprosate for Alcoholism Treatment: A Meta-Analysis". Alcoholism: Clinical and Experimental Research. 25 (9): 1335–41. doi:10.1111/j.1530-0277.2001.tb02356.x. PMID 11584154.
- Ray, Lara A.; Oslin, David W. (2009). "Naltrexone for the treatment of alcohol dependence among African Americans: Results from the COMBINE Study". Drug and Alcohol Dependence. 105 (3): 256–8. doi:10.1016/j.drugalcdep.2009.07.006. PMC . PMID 19717248.
- Ray, Lara A.; Barr, Christina S.; Blendy, Julie A.; Oslin, David; Goldman, David; Anton, Raymond F. (2012). "The Role of the Asn40Asp Polymorphism of the Mu Opioid Receptor Gene (OPRM1) on Alcoholism Etiology and Treatment: A Critical Review". Alcoholism: Clinical and Experimental Research. 36 (3): 385–94. doi:10.1111/j.1530-0277.2011.01633.x. PMC . PMID 21895723.
- Niciu, Mark J.; Arias, Albert J. (2013). "Targeted Opioid Receptor Antagonists in the Treatment of Alcohol Use Disorders". CNS Drugs. 27 (10): 777–87. doi:10.1007/s40263-013-0096-4. PMC . PMID 23881605.
- Codd, E. E.; Shank, R. P.; Schupsky, J. J.; Raffa, R. B. (1995). "Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: Structural determinants and role in antinociception". The Journal of Pharmacology and Experimental Therapeutics. 274 (3): 1263–70. PMID 7562497.
- Haber, Hanka; Roske, Irmgard; Rottmann, Matthias; Georgi, Monika; Melzig, Matthias F. (1996). "Alcohol induces formation of morphine precursors in the striatum of rats". Life Sciences. 60 (2): 79–89. doi:10.1016/S0024-3205(96)00597-8. PMID 9000113.
- "Alcoholism Once A Month Injectable Drug, Vivitrol, Approved By FDA," Medical News Today, April 16, 2006.
- Therapeutic Goods Administration. "Australian Register of Therapeutic Goods Medicines" (Online database of approved medicines). Retrieved 2009-03-22.
- Therapeutic Goods Administration. "Australian Register of Therapeutic Goods Medicines" (Online database of approved medicines, specific entry for "O'Neil Long Acting Naltrexone Implant"). Retrieved 2017-04-27.
- Hulse, Gary K.; Morris, Noella; Arnold-Reed, Diane; Tait, Robert J. (2009). "Improving Clinical Outcomes in Treating Heroin Dependence". Archives of General Psychiatry. 66 (10): 1108–15. doi:10.1001/archgenpsychiatry.2009.130. PMID 19805701.
- "A Shot in the Dark: Can Vivitrol Help Us Control Our Addictions?". 7 May 2013.
- Krupitsky, Evgeny; Nunes, Edward V.; Ling, Walter; Illeperuma, Ari; Gastfriend, David R.; Silverman, Bernard L. (April 28, 2011). "Injectable extended-release naltrexone for opioid dependence: a double-blind, placebo-controlled, multicentre randomised trial" (PDF). The Lancet via Research Gate. 377: 1506–13. doi:10.1016/S0140. Retrieved June 11, 2017.
- Wolfe, Daniel; Carrieri, MP; Dasgupta, Nabarun; Bruce, Douglas; Wodak, Alex (2011). "Injectable extended-release naltrexone for opioid dependence – Authors' reply". The Lancet. 378 (9792): 666. doi:10.1016/S0140-6736(11)61333-0.
- "Alcoholism Drug Abuse Weekly" (PDF). May 9, 2011. Archived from the original (PDF) on 2015-02-19.
- Wolfe, Daniel; Carrieri, M Patrizia; Dasgupta, Nabarun; Wodak, Alex; Newman, Robert; Bruce, R Douglas (2011). "Concerns about injectable naltrexone for opioid dependence". The Lancet. 377 (9776): 1468–70. doi:10.1016/S0140-6736(10)62056-9. PMID 21529930.
- Goodnough, Abby; Zernike, Kate (June 11, 2017). "Seizing on Opioid Crisis, a Drug Maker Lobbies Hard for Its Product". The New York Times. Retrieved June 11, 2017.
Advertising for Vivitrol on a subway car in Brooklyn last month. Marketing for the drug has shifted into high gear.
- "Letter to Tom Price". May 2017. Retrieved June 11, 2017.
- Daphne Simeon; Jeffrey Abugel (10 October 2008). Feeling Unreal: Depersonalization Disorder and the Loss of the Self. Oxford University Press. pp. 166–. ISBN 978-0-19-976635-2.
- Ulrich F. Lanius, PhD; Sandra L. Paulsen, PhD; Frank M. Corrigan, MD (13 May 2014). Neurobiology and Treatment of Traumatic Dissociation: Towards an Embodied Self. Springer Publishing Company. pp. 489–. ISBN 978-0-8261-0632-2.
- Sierra, Mauricio (2014). "Depersonalization disorder: Pharmacological approaches". Expert Review of Neurotherapeutics. 8 (1): 19–26. doi:10.1586/1473722.214.171.124. PMID 18088198.
- Novella, Steven (5 May 2010). "Low Dose Naltrexone – Bogus or Cutting Edge Science?". Science-Based Medicine. Retrieved 5 July 2011.
- Younger, Jarred; MacKey, Sean (2009). "Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study". Pain Medicine. 10 (4): 663–72. doi:10.1111/j.1526-4637.2009.00613.x. PMC . PMID 19453963.
- Bowling, Allen C. "Low-dose naltrexone (LDN) The "411" on LDN". National Multiple Sclerosis Society. Archived from the original on 22 December 2011. Retrieved 6 July 2011.
- King, Andrea; De Wit, Harriet; Riley, Roslynn; Cao, Dingcai; Niaura, Raymond; Hatsukami, Dorothy (2006). "Efficacy of naltrexone in smoking cessation: A preliminary study and an examination of sex differences". Nicotine & Tobacco Research. 8 (5): 671–82. doi:10.1080/14622200600789767. PMID 17008194.
- Smith, Stanley G.; Gupta, Krishan K.; Smith, Sylvia H. (1995). "Effects of naltrexone on self-injury, stereotypy, and social behavior of adults with developmental disabilities". Journal of Developmental and Physical Disabilities. 7 (2): 137–46. doi:10.1007/BF02684958.
- Manley, Cynthia (1998-03-20). "Self-injuries may have biochemical base: study". The Reporter.
- Grant, Jon E.; Kim, Suck Won; Odlaug, Brian L. (2009). "A Double-Blind, Placebo-Controlled Study of the Opiate Antagonist, Naltrexone, in the Treatment of Kleptomania". Biological Psychiatry. 65 (7): 600–6. doi:10.1016/j.biopsych.2008.11.022. PMID 19217077. Lay summary – Science Daily (April 3, 2009).
- "A Randomized, Double-Blind, Placebo-Controlled Trial of Naltrexone in the Treatment of Concurrent Alcohol Dependence and Pathological Gambling - ICH GCP - Clinical Trials Registry".
- Kim, Suck Won; Grant, Jon E; Adson, David E; Shin, Young Chul (2001). "Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling". Biological Psychiatry. 49 (11): 914–21. doi:10.1016/S0006-3223(01)01079-4. PMID 11377409.
- Bostwick, J. Michael; Bucci, Jeffrey A. (2008). "Internet Sex Addiction Treated with Naltrexone". Mayo Clinic Proceedings. 83 (2): 226–30. doi:10.4065/83.2.226. PMID 18241634.
- Vignau, J.; Karila, L.; Costisella, O.; Canva, V. (2005). "Hépatite C, Interféron α et dépression : Principales hypothèses physiopathologiques" [Hepatitis C, interferon a and depression: main physiopathologic hypothesis]. L'Encéphale (in French). 31 (3): 349–57. doi:10.1016/s0013-7006(05)82400-5. PMID 16142050. INIST:16920336.
- Małyszczak, Krzysztof; Inglot, Małgorzata; Pawłowski, Tomasz; Czarnecki, Marcin; Rymer, Weronika; Kiejna, Andrzej (2006). "Objawy neuropsychiatryczne w trakcie leczenia interferonem alfa" [Neuropsychiatric symptoms related to interferon alpha]. Psychiatria polska (in Polish). 40 (4): 787–97. PMID 17068950.