Infectious pancreatic necrosis birnavirus Vp4 peptidase

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Infectious pancreatic necrosis birnavirus Vp4 peptidase
Identifiers
EC number 3.4.21.115
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Infectious pancreatic necrosis birnavirus Vp4 peptidase (EC 3.4.21.115, infectious pancreatic necrosis virus protease, IPNV Vp4 protease, IPNV Vp4 peptidase, NS protease, NS-associated protease, Vp4 protease) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Cleaves the (Ser/Thr)-Xaa-Ala-(Ser/Ala)-Gly motif in the polyprotein NH2-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions

Infectious pancreatic necrosis virus is a birnavirus that causes an acute, contagious disease in young salmonid fish.

References[edit]

  1. ^ Manning, D.S.; Leong, J.C. (1990). "Expression in Escherichia coli of the large genomic segment of infectious pancreatic necrosis virus". Virology. 179: 16–25. doi:10.1016/0042-6822(90)90268-v. PMID 2219718. 
  2. ^ Petit, S.; Lejal, N.; Huet, J.C.; Delmas, B. (2000). "Active residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus". J. Virol. 74: 2057–2066. doi:10.1128/jvi.74.5.2057-2066.2000. PMC 111686Freely accessible. PMID 10666235. 
  3. ^ Dobos, P. (1995). "The molecular biology of infectious pancreatic necrosis virus (IPNV)". Annu. Rev. Fish Dis. 5: 25–54. doi:10.1016/0959-8030(95)00003-8. 

External links[edit]