WAY-161503

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WAY-161503
WAY-161503.svg
Systematic (IUPAC) name
8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one
Identifiers
CAS Number 75704-24-4
PubChem CID 3906894
ChemSpider 3130042
Chemical data
Formula C11H11Cl2N3O
Molar mass 272.13 g·mol−1

WAY-161503 is a full agonist of 5-HT2C receptors (Ki = 3.3 nM for displacement of DOI), ~6-fold less potent at 5-HT2A receptors (Ki = 18 nM) and 20-fold less potent at 5-HT2B receptors (Ki = 60 nM).[1] In functional studies, it stimulates calcium mobilization coupled to 5-HT2C, 5-HT2B, and 5-HT2A receptors with EC50 values of 0.8, 1.8, and 7 nM, respectively.[1] WAY-161503 has been reported to produce dose-dependent decreases in food intake in 24-hour fasted normal Sprague-Dawley rats, diet-induced obese mice, and obese Zucker rats with ED50 values of 1.9, 6.8, and 0.73 mg/kg, respectively.[1]

WAY-161503 has been used to examine the role of 5-HT2C receptors in rodent models of depression, locomotion, reinforcement, or motivated behaviors.[2][3]

References[edit]

  1. ^ a b c Sharon Rosenzweig-Lipson, Jean Zhang, Hossein Mazandarani, Boyd L. Harrison, Annmarie Sabb, Joan Sabalski, Gary Stack, Greg Welmaker, James E. Barrett, John Dunlop (February 2006). "Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503". Brain Research. 1073–1074: 240–251. doi:10.1016/j.brainres.2005.12.052. PMID 16430874. 
  2. ^ John F. Cryan, Irwin Lucki (December 2000). "Antidepressant-Like Behavioral Effects Mediated by 5-Hydroxytryptamine2C Receptors". The Journal of Pharmacology And Experimental Therapeutics 295 (3): 1120–1126. PMID 11082448. 
  3. ^ Dave J. Hayes, Tera M. Mosher, Andrew J. Greenshaw (February 2009). "Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats". Behavioural Brain Research 197 (2): 323–330. doi:10.1016/j.bbr.2008.08.034. PMID 18805442.