WDR4

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WDR4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWDR4, TRM82, TRMT82, WD repeat domain 4
External IDsMGI: 1889002 HomoloGene: 32422 GeneCards: WDR4
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for WDR4
Genomic location for WDR4
Band21q22.3Start42,843,094 bp[1]
End42,879,568 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021322

RefSeq (protein)

NP_067297

Location (UCSC)Chr 21: 42.84 – 42.88 MbChr 17: 31.49 – 31.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 is an enzyme that in humans is encoded by the WDR4 gene.[5]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene.[5]

References[edit]

Further reading[edit]