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Protein WDR5 PDB 2cnx.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases WDR5, BIG-3, CFAP89, SWD3, WD repeat-containing protein 5, WD repeat domain 5
External IDs MGI: 2155884 HomoloGene: 59931 GeneCards: WDR5
RNA expression pattern
PBB GE WDR5 gnf1h08370 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 9: 134.14 – 134.16 Mb Chr 2: 27.52 – 27.54 Mb
PubMed search [1] [2]
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WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.[3][4]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.[4]


WDR5 has been shown to interact with Host cell factor C1[5][6] and MLL.[5] It also interacts with the long non-coding RNA HOTTIP.[7] WDR5 is a key determinant for MYC recruitment to chromatin[8]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Gori F, Divieti P, Demay MB (Dec 2001). "Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation". J Biol Chem. 276 (49): 46515–22. doi:10.1074/jbc.M105757200. PMID 11551928. 
  4. ^ a b "Entrez Gene: WDR5 WD repeat domain 5". 
  5. ^ a b Yokoyama, Akihiko; Wang Zhong; Wysocka Joanna; Sanyal Mrinmoy; Aufiero Deborah J; Kitabayashi Issay; Herr Winship; Cleary Michael L (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Mol. Cell. Biol. United States. 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. ISSN 0270-7306. PMC 480881Freely accessible. PMID 15199122. 
  6. ^ Wysocka, Joanna; Myers Michael P; Laherty Carol D; Eisenman Robert N; Herr Winship (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes Dev. United States. 17 (7): 896–911. doi:10.1101/gad.252103. ISSN 0890-9369. PMC 196026Freely accessible. PMID 12670868. 
  7. ^ Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, et al. (2011). "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.". Nature. 472 (7341): 120–4. doi:10.1038/nature09819. PMID 21423168. 
  8. ^ Thomas, L. R.; Tansey, W. P. (2015). "Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC". Molecular Cell. 58 (3): 1–13. doi:10.1016/j.molcel.2015.02.028. PMC 4427524Freely accessible. PMID 25818646. 

Further reading[edit]