WEPX and WPXU were affiliates of MyNetworkTV from September 5, 2006 until September 27, 2009 when MyNetworkTV's affiliation switched over to WITN-TV, prior to this, the stations were solely affiliates of ION (then known as i and originally known as PAX TV). WEPX 38.1 is now broadcasting in High Definition.
Because it was granted an original construction permit after the FCC finalized the DTV allotment plan on April 21, 1997 , the station did not initially receive a companion channel for a digital television station. WEPX was later assigned channel 51, and the digital signal signed on February 5, 2008. WEPX has filed a letter with the FCC requesting to move from channel 51 to channel 26. This is part of a larger move for the FCC to get TV stations off of channel 51 to prevent interference with cell phone devices. The station's digital channel is multiplexed: