The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family.
WNT10A is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.
^Kirikoshi H, Sekihara H, Katoh M (May 2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID11350055.
Memarian A, Hojjat-Farsangi M, Asgarian-Omran H, et al. (2009). "Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia". Leuk. Lymphoma. 50 (12): 2061–70. doi:10.3109/10428190903331082. PMID19863181.