WNT10B

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WNT10B
Identifiers
Aliases WNT10B, SHFM6, WNT-12, Wnt family member 10B
External IDs MGI: 108061 HomoloGene: 20721 GeneCards: WNT10B
RNA expression pattern
PBB GE WNT10B 206213 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003394

NM_011718

RefSeq (protein)

NP_003385

NP_035848.1
NP_035848

Location (UCSC) Chr 12: 48.97 – 48.97 Mb Chr 15: 98.77 – 98.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein Wnt-10b (formerly Wnt12[3]) is a protein that in humans is encoded by the WNT10B gene.[4][5][6][7]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs adipogenesis. Gain-of-function of Wnt10b in mouse hearts has shown to improve cardiac tissue repair after myocardial injury, by promoting coronary vessel formation and attenuating pathological fibrosis.[8] This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Schubert M, Holland LZ, Holland ND, Jacobs DK (2000). "A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus". Molecular Biology and Evolution. 17 (12): 1896–903. doi:10.1093/oxfordjournals.molbev.a026291. PMID 11110906. 
  4. ^ Bui TD, Rankin J, Smith K, Huguet EL, Ruben S, Strachan T, Harris AL, Lindsay S (Apr 1997). "A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas". Oncogene. 14 (10): 1249–53. doi:10.1038/sj.onc.1200936. PMID 9121776. 
  5. ^ Hardiman G, Kastelein RA, Bazan JF (Sep 1997). "Isolation, characterization and chromosomal localization of human WNT10B". Cytogenet Cell Genet. 77 (3–4): 278–82. doi:10.1159/000134597. PMID 9284937. 
  6. ^ Ugur SA, Tolun A (Aug 2008). "Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation". Hum Mol Genet. 17 (17): 2644–53. doi:10.1093/hmg/ddn164. PMID 18515319. 
  7. ^ a b "Entrez Gene: WNT10B wingless-type MMTV integration site family, member 10B". 
  8. ^ Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK. Wnt10b gain-of-function improves cardiac repair by arteriole formation and attenuation of fibrosis. Circ Res. 2015; 117:804-816.

Further reading[edit]